Gene Page: APH1A

Summary
GeneID  51107
Symbol  APH1A
Synonyms  6530402N02Rik|APH-1A|CGI-78
Description  anterior pharynx defective 1 homolog A (C. elegans)
See related  HGNC:29509|MIM:607629|Ensembl:ENSG00000117362|
Locus tag  RP4-790G17.3
Gene type  protein-coding
Map location  1p36.13-q31.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12297508 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042987amyloid precursor protein catabolic processIMP12297508 
GO:0006509membrane protein ectodomain proteolysisIDA15274632 
GO:0007220Notch receptor processingIMP12297508 
GO:0016485protein processingIDA15274632 
GO:0016485protein processingIEA-
GO:0031293membrane protein intracellular domain proteolysisIMP12297508 
GO:0043085positive regulation of catalytic activityIDA15274632 
GO:0043085positive regulation of catalytic activityIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA15274632 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005783endoplasmic reticulumIDA15274632 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005887integral to plasma membraneIDA15274632 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NCSTNAPH2 | KIAA0253nicastrin-HPRD,BioGRID12297508 
PSEN1AD3 | FAD | PS1 | S182presenilin 1APH-1A interacts with PSEN1.BIND12297508 
Affinity Capture-Western
Co-fractionation		BioGRID12297508 |12471034 
|14572442 
PSEN2AD3L | AD4 | PS2 | STM2presenilin 2 (Alzheimer disease 4)-HPRD,BioGRID12297508 |12471034 
PSENENMDS033 | MSTP064 | PEN-2 | PEN2presenilin enhancer 2 homolog (C. elegans)-HPRD,BioGRID12740439 |14572442 
PEN-2 interacts with APH-1.BIND15322109 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_NOTCH_SIGNALING_PATHWAY 4735All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_SYNDECAN_3_PATHWAY 1715All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 3830All SZGR genes in this pathway
REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 2718All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH4 1210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH2 1210All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH1 7046All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH3 1210All SZGR genes in this pathway
REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 109All SZGR genes in this pathway
REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 1510All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_NOTCH 10364All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_UP 11466All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP 10866All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_UP 9264All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_DN 129All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANGOLKAR_H2AFY_TARGETS_UP 4828All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1225225281Ahsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-204/21198104m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-5392062121Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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