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| GeneID |
5126
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| Symbol |
PCSK2
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| Synonyms |
NEC2|PC2|SPC2
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| Description |
proprotein convertase subtilisin/kexin type 2 |
| See related |
HGNC:8744|MIM:162151|Ensembl:ENSG00000125851|HPRD:01202| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
20p11.2 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| GSMA_I | genome scan meta-analysis | Psr: 0.046 | | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 2 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
|
| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| TJAP1 | 0.78 | 0.79 | | |
| DNHD1 | 0.77 | 0.80 | | |
| PHLDB1 | 0.72 | 0.70 | | |
| KIAA1755 | 0.71 | 0.62 | | |
| TBC1D2 | 0.70 | 0.72 | | |
| PLEKHG3 | 0.69 | 0.64 | | |
| SLC45A3 | 0.68 | 0.68 | | |
| CC2D1B | 0.68 | 0.71 | | |
| MYO15B | 0.68 | 0.66 | | |
| MYO15B | 0.67 | 0.69 | | |
Top 10 negatively co-expressed genes | | CARD16 | -0.37 | -0.35 | | |
| CAPZA2 | -0.36 | -0.36 | | |
| BRP44 | -0.36 | -0.40 | | |
| SNX3 | -0.34 | -0.33 | | |
| NGB | -0.34 | -0.36 | | |
| COMMD7 | -0.34 | -0.35 | | |
| GPR160 | -0.34 | -0.38 | | |
| PPEF1 | -0.32 | -0.24 | | |
| B4GALT2 | -0.32 | -0.30 | | |
| NPPA | -0.31 | -0.31 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0004252 | serine-type endopeptidase activity | IEA | glutamate (GO term level: 7) | - |
| GO:0005515 | protein binding | IPI | | 7913882 |
| GO:0008233 | peptidase activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0007399 | nervous system development | IEA | neurite (GO term level: 5) | - |
| GO:0006508 | proteolysis | IEA | | - |
| GO:0034230 | enkephalin processing | ISS | | - |
| GO:0034231 | islet amyloid polypeptide processing | ISS | | - |
| GO:0016540 | protein autoprocessing | IEA | | - |
| GO:0030070 | insulin processing | IDA | | 7626024 |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005615 | extracellular space | IDA | | 9020868 |
| GO:0005625 | soluble fraction | IDA | | 8034613 |
| GO:0016020 | membrane | IDA | | 8034613 |
| GO:0031410 | cytoplasmic vesicle | IEA | | - |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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