Gene Page: PDE4A

Summary
GeneID  5141
Symbol  PDE4A
Synonyms  DPDE2|PDE4|PDE46
Description  phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)
See related  HGNC:8780|MIM:600126|Ensembl:ENSG00000065989|HPRD:02527|
Locus tag  -
Gene type  protein-coding
Map location  19p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC134043.10.930.12
EBF10.930.28
RARB0.910.62
PBX30.890.35
IKZF10.840.37
GPR1490.840.58
C10orf410.810.59
DLX60.780.55
ZNF5210.750.51
DACH10.750.50
Top 10 negatively co-expressed genes
CDADC1-0.230.23
EMID1-0.18-0.20
CCDC90A-0.18-0.15
GTDC1-0.170.16
IGSF21-0.170.01
RHCG-0.17-0.02
GARNL3-0.170.05
CHPT1-0.170.09
SLC26A4-0.170.20
NXPH3-0.16-0.05
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:00041153',5'-cyclic-AMP phosphodiesterase activityNAS8413254 
GO:00041153',5'-cyclic-AMP phosphodiesterase activityTAS9677330 
GO:0016787hydrolase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS8940140 
GO:0009187cyclic nucleotide metabolic processNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND-
GO:0005624membrane fractionTAS9677330 
GO:0005625soluble fractionTAS8940140 
GO:0016020membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP6ADAP100 | ADAP6 | AKAP100 | KIAA0311 | MGC165020 | PRKA6 | mAKAPA kinase (PRKA) anchor protein 6Affinity Capture-WesternBioGRID11296225 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID10206997 
PDE4ADPDE2 | PDE4 | PDE46phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)-HPRD11566027 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alphaAffinity Capture-WesternBioGRID11296225 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_MYELOID_UP 3019All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
KERLEY_RESPONSE_TO_CISPLATIN_UP 4430All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_17 2512All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
CHUNG_BLISTER_CYTOTOXICITY_UP 13484All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 142103All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MIKKELSEN_IPS_LCP_WITH_H3K4ME3 174100All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_DN 242146All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101136813751A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124.19079141A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5069079131Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-13512451251m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-137108310901A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1393143211A,m8hsa-miR-139brainUCUACAGUGCACGUGUCU
hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-144136913751Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-188230236m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-7612618m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.