Gene Page: PI4KA

Summary
GeneID  5297
Symbol  PI4KA
Synonyms  FLJ16556|PI4K-ALPHA|PIK4CA|pi4K230
Description  phosphatidylinositol 4-kinase, catalytic, alpha
See related  HGNC:8983|MIM:600286|Ensembl:ENSG00000133511|HPRD:08972|
Locus tag  -
Gene type  protein-coding
Map location  22q11.21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LTB4R20.610.59
LHX20.590.56
TMEM1450.590.64
TMCO60.580.64
MOGS0.570.64
TIRAP0.570.69
IL27RA0.570.58
OVCA20.560.60
RDH50.560.59
MACROD10.560.56
Top 10 negatively co-expressed genes
AF347015.31-0.41-0.48
AF347015.27-0.40-0.47
AF347015.21-0.39-0.51
AF347015.2-0.39-0.48
AF347015.8-0.38-0.45
MT-ATP8-0.38-0.50
MT-CO2-0.38-0.44
MT-CYB-0.38-0.45
AF347015.33-0.35-0.43
AL139819.3-0.34-0.40
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI14676841 
GO:0004428inositol or phosphatidylinositol kinase activityIEA-
GO:00044301-phosphatidylinositol 4-kinase activityTAS8662589 
GO:0016740transferase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8662589 
GO:0006661phosphatidylinositol biosynthetic processTAS7961848 
GO:0007165signal transductionNAS7961848 
GO:0048015phosphoinositide-mediated signalingIEA-
GO:0046854phosphoinositide phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005798Golgi-associated vesicleTAS8662589 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD4CD4mutCD4 molecule-HPRD8246987 
CD7GP40 | LEU-9 | TP41 | Tp40CD7 molecule-HPRD12594831 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinaseReconstituted ComplexBioGRID8246987 
STRN4FLJ35594 | ZIN | zinedinstriatin, calmodulin binding protein 4Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INOSITOL_PHOSPHATE_METABOLISM 5442All SZGR genes in this pathway
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 7656All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 1710All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_PI_METABOLISM 4834All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
HOWLIN_PUBERTAL_MAMMARY_GLAND 6940All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
ROSS_ACUTE_MYELOID_LEUKEMIA_CBF 8257All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
CERIBELLI_PROMOTERS_INACTIVE_AND_BOUND_BY_NFY 4420All SZGR genes in this pathway


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