Gene Page: PML

Summary
GeneID  5371
Symbol  PML
Synonyms  MYL|PP8675|RNF71|TRIM19
Description  promyelocytic leukemia
See related  HGNC:9113|MIM:102578|Ensembl:ENSG00000140464|HPRD:00023|
Locus tag  -
Gene type  protein-coding
Map location  15q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0455 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingNAS1652369 
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI9294197 |9671405 |11259576 
|11432836 |12915590 
|14976184 |15626733 
|16915281 
GO:0008270zinc ion bindingIEA-
GO:0008270zinc ion bindingNAS1652369 
GO:0016564transcription repressor activityIDA11432836 
GO:0032183SUMO bindingIPI17081985 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001666response to hypoxiaIDA16915281 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006461protein complex assemblyIDA12915590 
GO:0006281DNA repairNAS12773567 
GO:0006917induction of apoptosisIMP16912307 
GO:0010212response to ionizing radiationIDA12773567 
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestISS-
GO:0016481negative regulation of transcriptionIDA9448006 
GO:0016525negative regulation of angiogenesisIMP16915281 
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisISS-
GO:0030308negative regulation of cell growthIDA9448006 
GO:0030578PML body organizationIMP17081985 
GO:0044419interspecies interaction between organismsIEA-
GO:0051457maintenance of protein location in nucleusIDA17332504 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005626insoluble fractionIDA12915590 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmIDA12915590 
GO:0005730nucleolusIDA15195100 
GO:0005737cytoplasmIDA16778193 
GO:0005737cytoplasmIEA-
GO:0016605PML bodyIDA9448006 |17081985 
GO:0016605PML bodyIDA10910364 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANKRD2ARPP | MGC104314ankyrin repeat domain 2 (stretch responsive muscle)-HPRD,BioGRID15136035 
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocator-HPRD,BioGRID12354770 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2Reconstituted ComplexBioGRID9671405 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedATR phosphorylates PML.BIND15195100 
AURKAAIK | ARK1 | AURA | AURORA2 | BTAK | MGC34538 | STK15 | STK6 | STK7aurora kinase APML3 interacts with Aurora A.BIND15749021 
BCL6BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51B-cell CLL/lymphoma 6Two-hybridBioGRID11175338 
CCNT1CCNT | CYCT1cyclin T1-HPRD,BioGRID12727882 
CHFRFLJ10796 | FLJ33629 | RNF116 | RNF196checkpoint with forkhead and ring finger domainsCHFR interacts an unspecified isoform of PML.BIND15467728 
-HPRD,BioGRID15467728 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD10077561 |10610177 
|12142048 |12234245 
|12622724 
Affinity Capture-Western
Reconstituted Complex		BioGRID10077561 |10610177 
|12622724 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated protein-HPRD10525530 |10669754 
|10684855 |12595526 
Affinity Capture-Western
Co-localization
Two-hybrid		BioGRID10525530 |10669754 
|10684855 |11244500 
EIF4ECBP | EIF4E1 | EIF4EL1 | EIF4F | MGC111573eukaryotic translation initiation factor 4E-HPRD,BioGRID11500381 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD,BioGRID9671405 
GATA2MGC2306 | NFE1BGATA binding protein 2-HPRD,BioGRID10938104 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID11259576 |11430826 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID11259576 |11430826 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-Western
Reconstituted Complex		BioGRID11259576 
HHEXHEX | HMPH | HOX11L-PEN | PRH | PRHXhematopoietically expressed homeobox-HPRD,BioGRID10597310 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID9671405 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11Affinity Capture-Western
Reconstituted Complex		BioGRID15273249 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD15273249 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)PML interacts with Mdm2.BIND15195100 
-HPRD,BioGRID12759344 |12915590 
|14507915 |15195100 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1-HPRD11430826 
MYBCmyb | c-myb | c-myb_CDS | efgv-myb myeloblastosis viral oncogene homolog (avian)-HPRD,BioGRID15194430 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Myc interacts with PML. This interaction was modelled on a demonstrated interaction between mouse Myc and human PML.BIND15735755 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1-HPRD,BioGRID11430826 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD,BioGRID11585900 
NR4A1GFRP1 | HMR | MGC9485 | N10 | NAK-1 | NGFIB | NP10 | NUR77 | TR3nuclear receptor subfamily 4, group A, member 1-HPRD,BioGRID12032831 
PAWRPAR4 | Par-4PRKC, apoptosis, WT1, regulator-HPRD12717420 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemiaFar WesternBioGRID10669754 
RARANR1B1 | RARretinoic acid receptor, alpha-HPRD12935927 
Reconstituted ComplexBioGRID10610177 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID9448006 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID12540841 
RPL11GIG34ribosomal protein L11PML interacts with L11 in the nucleolus.BIND15195100 
Affinity Capture-Western
Reconstituted Complex		BioGRID15195100 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alphaReconstituted ComplexBioGRID10610177 
SENP2AXAM2 | DKFZp762A2316 | KIAA1331 | SMT3IP2SUMO1/sentrin/SMT3 specific peptidase 2-HPRD12419228 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Affinity Capture-Western
Reconstituted Complex		BioGRID11430826 
SKISKVv-ski sarcoma viral oncogene homolog (avian)-HPRD,BioGRID11430826 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID15356634 
cPML interacts with Smad2.BIND15356634 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3cPML interacts with Smad3.BIND15356634 
-HPRD,BioGRID15356634 
SP1-Sp1 transcription factor-HPRD,BioGRID9819401 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD,BioGRID12622724 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID12506013 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)-HPRD8806687 |11080164 
Affinity Capture-Western
in vitro
in vivo
Two-hybrid		BioGRID8806687 |9452416 
|11948183 
SUMO2HSMT3 | MGC117191 | SMT3B | SMT3H2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-HPRD9452416 
TDG-thymine-DNA glycosylase-HPRD,BioGRID15569683 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1-HPRD15356634 
cPML interacts with T-beta-RI.BIND15356634 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)cPML interacts with T-beta-RII.BIND15356634 
-HPRD15356634 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)-HPRD10610177 
TOPBP1TOP2BP1topoisomerase (DNA) II binding protein 1-HPRD,BioGRID12773567 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-Western
Reconstituted Complex		BioGRID11025664 |11080164 
|12915590 
-HPRD11025664 |11080164 
|11704853 
TP73P73tumor protein p73-HPRD11832207 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24-HPRD,BioGRID10610177 
TRIM27RFP | RNF76tripartite motif-containing 27-HPRD,BioGRID9570750 
TRIM69HSD34 | RNF36 | Triftripartite motif-containing 69-HPRD,BioGRID12837286 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Biochemical ActivityBioGRID18691969 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD,BioGRID9294197 |11175338 
ZFYVE9MADHIP | NSP | SARA | SMADIPzinc finger, FYVE domain containing 9-HPRD,BioGRID15356634 
cPML interacts with SARA.BIND15356634 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_ACUTE_MYELOID_LEUKEMIA 6047All SZGR genes in this pathway
BIOCARTA_PML_PATHWAY 1712All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_MYC_PATHWAY 2522All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_INTERFERON_GAMMA_SIGNALING 6348All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_YELLOW_DN 2315All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
VETTER_TARGETS_OF_PRKCA_AND_ETS1_UP 168All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
OXFORD_RALB_TARGETS_DN 96All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_7 2722All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
MORI_IMMATURE_B_LYMPHOCYTE_UP 5335All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP 7448All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
SU_PANCREAS 5430All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
BROWNE_INTERFERON_RESPONSIVE_GENES 6844All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
TSENG_IRS1_TARGETS_DN 13588All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN 8858All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
ZHU_CMV_8_HR_UP 4739All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C5 107All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
BOSCO_INTERFERON_INDUCED_ANTIVIRAL_MODULE 7848All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.