Gene Page: PPP3CA

Summary
GeneID  5530
Symbol  PPP3CA
Synonyms  CALN|CALNA|CALNA1|CCN1|CNA1|PPP2B
Description  protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
See related  HGNC:9314|MIM:114105|Ensembl:ENSG00000138814|HPRD:00234|
Locus tag  -
Gene type  protein-coding
Map location  4q21-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 6.0623 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TMF10.940.95
PIK3C30.940.93
POLK0.930.95
APPBP20.930.93
CUL4B0.920.94
IPO70.920.94
TTC21B0.920.93
API5L10.920.92
KIAA10120.920.93
ZBTB110.910.93
Top 10 negatively co-expressed genes
MT-CO2-0.69-0.74
FXYD1-0.68-0.74
AF347015.31-0.68-0.73
HIGD1B-0.67-0.74
IFI27-0.67-0.74
AF347015.21-0.66-0.71
MT-CYB-0.65-0.70
CST3-0.65-0.73
CXCL14-0.65-0.72
AF347015.8-0.65-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005506iron ion bindingIEA-
GO:0005509calcium ion bindingNAS8392375 
GO:0005516calmodulin bindingNAS8392375 
GO:0004722protein serine/threonine phosphatase activityNAS8392375 
GO:0016787hydrolase activityIEA-
GO:0008270zinc ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0050804regulation of synaptic transmissionIEAneuron, Synap (GO term level: 7)-
GO:0000082G1/S transition of mitotic cell cycleIEA-
GO:0006470protein amino acid dephosphorylationNAS8392375 
GO:0006950response to stressIEA-
GO:0006606protein import into nucleusIEA-
GO:0006816calcium ion transportIEA-
GO:0048741skeletal muscle fiber developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0030018Z discIEA-
GO:0005955calcineurin complexNAS8392375 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surfaceCo-fractionationBioGRID9880537 
AKAP5AKAP75 | AKAP79 | H21A kinase (PRKA) anchor protein 5-HPRD,BioGRID7528941 |9765270 
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID7593193 |9109491 
C16orf74MGC17624chromosome 16 open reading frame 74Two-hybridBioGRID16189514 
CABIN1CAIN | KIAA0330 | PPP3INcalcineurin binding protein 1Two-hybridBioGRID9655484 
-HPRD11714752 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD11478781 
CRTC2RP11-422P24.6 | TORC2CREB regulated transcription coactivator 2TORC2 interacts with CnA.BIND15454081 
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDa-HPRD7543369 
FKBP8FKBP38 | FKBPr38FK506 binding protein 8, 38kDa-HPRD12510191 
MYOZ1CS-2 | FATZ | MYOZmyozenin 1Affinity Capture-WesternBioGRID11114196 
MYOZ2C4orf5 | CS-1myozenin 2Affinity Capture-WesternBioGRID11114196 
-HPRD11842093 
MYOZ3CS-3 | CS3 | FRP3myozenin 3-HPRD11842093 
PPIACYPA | CYPH | MGC117158 | MGC12404 | MGC23397peptidylprolyl isomerase A (cyclophilin A)-HPRD,BioGRID12218175 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD12021260 
RCAN1ADAPT78 | CSP1 | DSC1 | DSCR1 | MCIP1 | RCN1regulator of calcineurin 1-HPRD,BioGRID10861295 
RCAN2CSP2 | DSCR1L1 | MCIP2 | RCN2 | ZAKI-4 | ZAKI4 | hRCN2regulator of calcineurin 2Reconstituted ComplexBioGRID12102656 
SOD1ALS | ALS1 | IPOA | SOD | homodimersuperoxide dismutase 1, soluble-HPRD11513882 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY 3728All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_CALCINEURIN_PATHWAY 2117All SZGR genes in this pathway
BIOCARTA_NDKDYNAMIN_PATHWAY 2115All SZGR genes in this pathway
BIOCARTA_FCER1_PATHWAY 4130All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_VIP_PATHWAY 2926All SZGR genes in this pathway
BIOCARTA_NFAT_PATHWAY 5645All SZGR genes in this pathway
BIOCARTA_NOS1_PATHWAY 2421All SZGR genes in this pathway
BIOCARTA_CK1_PATHWAY 1717All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY 2620All SZGR genes in this pathway
BIOCARTA_MEF2D_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY 4937All SZGR genes in this pathway
SIG_BCR_SIGNALING_PATHWAY 4638All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
PID_IL12_STAT4_PATHWAY 3329All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_DARPP_32_EVENTS 2520All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
LIU_PROSTATE_CANCER_UP 9657All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP 164122All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
JOHANSSON_GLIOMAGENESIS_BY_PDGFB_DN 2116All SZGR genes in this pathway
LANG_MYB_FAMILY_TARGETS 2916All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
DER_IFN_ALPHA_RESPONSE_UP 7448All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
DER_IFN_BETA_RESPONSE_UP 10267All SZGR genes in this pathway
SANA_RESPONSE_TO_IFNG_UP 7850All SZGR genes in this pathway
DER_IFN_GAMMA_RESPONSE_UP 7145All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_DN 138All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C8 7256All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN 314188All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_AND_UV_RADIATION 8865All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_UP 2014All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_1_DN 6339All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway
CHEMELLO_SOLEUS_VS_EDL_MYOFIBERS_DN 1910All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/986386441Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-103/10768741Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-142-3p141114171Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-142-5p102910361A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-1457367431A,m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-153925931m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d20482054m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1866486541Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-2085415471Ahsa-miR-208AUAAGACGAGCAAAAAGCUUGU
miR-2111291135m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-30-3p134613521Ahsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-30-5p4124181Ahsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-319298m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-330108310891Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-34b9219271Ahsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-378*13651371m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-381131213181Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-49520192025m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-4995405471A,m8hsa-miR-499UUAAGACUUGCAGUGAUGUUUAA
miR-5432922981Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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