|
GeneID |
5538
|
Symbol |
PPT1
|
Synonyms |
CLN1|INCL|PPT
|
Description |
palmitoyl-protein thioesterase 1 |
See related |
HGNC:9325|MIM:600722|Ensembl:ENSG00000131238|HPRD:07203| |
Locus tag |
RP11-115D7.2 |
Gene type |
protein-coding |
Map location |
1p32 |
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Gene set name |
Method of gene set |
Evidence |
Info |
Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 11 | |
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General Gene Expression (microarray) ? |
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Gene Expression in Brain Regions (new) |
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Top co-expressed genes in Brain Regions (new) |
|
Gene | Pearson's Correlation | Spearman's Correlation | | |
Top 10 positively co-expressed genes |
NECAB2 | 0.80 | 0.78 | | |
CNTN6 | 0.79 | 0.65 | | |
ANXA3 | 0.78 | 0.53 | | |
CALB2 | 0.77 | 0.55 | | |
EGFL6 | 0.75 | 0.53 | | |
NEFL | 0.73 | 0.68 | | |
DOK7 | 0.71 | 0.59 | | |
OTX2 | 0.71 | -0.04 | | |
TP53I3 | 0.70 | 0.08 | | |
SLC17A6 | 0.69 | 0.43 | | |
Top 10 negatively co-expressed genes | FOXG1B | -0.27 | -0.36 | | |
SMTN | -0.26 | -0.53 | | |
ISLR2 | -0.25 | -0.27 | | |
SIGIRR | -0.25 | -0.43 | | |
ZEB2 | -0.25 | -0.32 | | |
LZTS1 | -0.24 | -0.27 | | |
TTC28 | -0.24 | -0.34 | | |
EMX1 | -0.24 | -0.22 | | |
MPPED1 | -0.24 | -0.24 | | |
NEUROD2 | -0.24 | -0.30 | | |
|
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0016787 | hydrolase activity | IEA | | - |
GO:0008474 | palmitoyl-(protein) hydrolase activity | IDA | | 10658183 |10737604 |
GO:0008474 | palmitoyl-(protein) hydrolase activity | IEA | | - |
GO:0008474 | palmitoyl-(protein) hydrolase activity | IMP | | 7637805 |
GO:0008474 | palmitoyl-(protein) hydrolase activity | ISS | | - |
GO:0016290 | palmitoyl-CoA hydrolase activity | IDA | | 10658183 |
GO:0016290 | palmitoyl-CoA hydrolase activity | ISS | | - |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0007420 | brain development | IEP | Brain (GO term level: 7) | 10992246 |
GO:0007420 | brain development | IMP | Brain (GO term level: 7) | 7637805 |
GO:0048666 | neuron development | TAS | neuron (GO term level: 9) | 11136716 |
GO:0007269 | neurotransmitter secretion | IEA | neuron, axon, Synap, serotonin, Neurotransmitter, dopamine (GO term level: 8) | - |
GO:0050803 | regulation of synapse structure and activity | NAS | neuron, Synap (GO term level: 7) | 11136716 |
GO:0043524 | negative regulation of neuron apoptosis | IMP | neuron (GO term level: 9) | 10737604 |11020216 |
GO:0007399 | nervous system development | IMP | neurite (GO term level: 5) | 7637805 |
GO:0002084 | protein depalmitoylation | IDA | | 10658183 |10737604 |
GO:0002084 | protein depalmitoylation | ISS | | - |
GO:0006309 | DNA fragmentation during apoptosis | IDA | | 15929065 |
GO:0006464 | protein modification process | IEA | | - |
GO:0016042 | lipid catabolic process | IDA | | 8816748 |
GO:0007042 | lysosomal lumen acidification | IMP | | 11722572 |
GO:0008306 | associative learning | IEA | | - |
GO:0008344 | adult locomotory behavior | IEA | | - |
GO:0007625 | grooming behavior | IEA | | - |
GO:0007601 | visual perception | IEA | | - |
GO:0015031 | protein transport | IMP | | 10737604 |
GO:0050896 | response to stimulus | IEA | | - |
GO:0051181 | cofactor transport | IMP | | 16542649 |
GO:0051186 | cofactor metabolic process | IMP | | 16542649 |
GO:0048260 | positive regulation of receptor-mediated endocytosis | IMP | | 16542649 |
GO:0031579 | membrane raft organization | IMP | | 15929065 |
GO:0030149 | sphingolipid catabolic process | TAS | | 16542649 |
GO:0030308 | negative regulation of cell growth | IMP | | 10737604 |
GO:0032429 | regulation of phospholipase A2 activity | IEA | | - |
GO:0044257 | cellular protein catabolic process | IEA | | - |
GO:0048549 | positive regulation of pinocytosis | IMP | | 16542649 |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
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GO:0043025 | cell soma | IEA | axon, dendrite (GO term level: 4) | - |
GO:0008021 | synaptic vesicle | IDA | Synap, Neurotransmitter (GO term level: 12) | 12483688 |
GO:0030425 | dendrite | IEA | neuron, axon, dendrite (GO term level: 6) | - |
GO:0030424 | axon | IDA | neuron, axon, Neurotransmitter (GO term level: 6) | 12483688 |
GO:0005794 | Golgi apparatus | IDA | | 7637805 |
GO:0005829 | cytosol | ISS | | - |
GO:0005576 | extracellular region | IDA | | 8895569 |
GO:0005576 | extracellular region | ISS | | - |
GO:0005615 | extracellular space | IEA | | - |
GO:0005624 | membrane fraction | ISS | | - |
GO:0005634 | nucleus | IDA | | 10992246 |
GO:0005764 | lysosome | IDA | | 8895569 |11020216 |
GO:0005764 | lysosome | ISS | | - |
GO:0045121 | membrane raft | IDA | | 15929065 |
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