Gene Page: PRIM2

Summary
GeneID  5558
Symbol  PRIM2
Synonyms  MGC75142|PRIM2A|p58
Description  primase, DNA, polypeptide 2 (58kDa)
See related  HGNC:9370|MIM:176636|Ensembl:ENSG00000146143|HPRD:08900|
Locus tag  RP3-401D24.1
Gene type  protein-coding
Map location  6p12-p11.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CALM30.910.91
ARF30.890.89
DLG40.890.87
SEPT50.880.84
FBXO440.880.89
RAB3A0.880.87
STK32C0.880.90
CGREF10.880.89
ARPC5L0.880.89
MLF20.880.87
Top 10 negatively co-expressed genes
AF347015.18-0.52-0.18
NSBP1-0.49-0.41
RAB13-0.47-0.52
AP002478.3-0.44-0.31
AF347015.21-0.44-0.11
AL139819.3-0.44-0.31
AC010300.1-0.44-0.30
MYLK2-0.43-0.38
AF347015.26-0.42-0.11
AF347015.2-0.42-0.11
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003896DNA primase activityTAS8026492 
GO:0005506iron ion bindingIEA-
GO:0016779nucleotidyltransferase activityIEA-
GO:0016740transferase activityIEA-
GO:0046872metal ion bindingIEA-
GO:00515394 iron, 4 sulfur cluster bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006350transcriptionIEA-
GO:0006269DNA replication, synthesis of RNA primerTAS8026492 
GO:0006260DNA replicationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005654nucleoplasmEXP6693436 |9822671 |11473323 
GO:0005658alpha DNA polymerase:primase complexIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
POLA2FLJ21662 | FLJ37250polymerase (DNA directed), alpha 2 (70kD subunit)-HPRD9705292 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_PYRIMIDINE_METABOLISM 9853All SZGR genes in this pathway
KEGG_DNA_REPLICATION 3621All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 3116All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 1510All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_M_G1_TRANSITION 8145All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_POL_SWITCHING 139All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_MITOTIC_M_M_G1_PHASES 17298All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_LAGGING_STRAND_SYNTHESIS 1912All SZGR genes in this pathway
REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 136All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_TELOMERE_MAINTENANCE 7557All SZGR genes in this pathway
REACTOME_EXTENSION_OF_TELOMERES 2717All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_DNA_STRAND_ELONGATION 3018All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BENPORATH_PROLIFERATION 14780All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP 11069All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
SHEPARD_CRUSH_AND_BURN_MUTANT_DN 185111All SZGR genes in this pathway
REN_BOUND_BY_E2F 6140All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_1_DN 163115All SZGR genes in this pathway
HOEGERKORP_CD44_TARGETS_TEMPORAL_UP 138All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP 203135All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_DN 6746All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN 271175All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_RACE_UP 299167All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHANG_CYCLING_GENES 14883All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_UP 3624All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
WINNEPENNINCKX_MELANOMA_METASTASIS_UP 16286All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_2HR_DN 4933All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_S 16286All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway


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