Gene Page: PRKAB1

Summary
GeneID  5564
Symbol  PRKAB1
Synonyms  AMPK|HAMPKb|MGC17785
Description  protein kinase, AMP-activated, beta 1 non-catalytic subunit
See related  HGNC:9378|MIM:602740|Ensembl:ENSG00000111725|HPRD:04116|
Locus tag  -
Gene type  protein-coding
Map location  12q24.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.126 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PDE7B0.800.78
INF20.790.74
FBXL160.780.77
IL17RA0.770.77
SMAD30.760.79
SLC6A10.750.85
STIM10.750.77
AGFG20.750.75
ACTN10.740.71
RAP1GAP0.730.66
Top 10 negatively co-expressed genes
RPL24-0.48-0.59
RPS3AP47-0.47-0.55
RPL31-0.46-0.57
RPL27-0.46-0.56
RPL35A-0.46-0.61
C12orf45-0.46-0.54
RPS23-0.46-0.57
RPS20-0.46-0.61
EXOSC8-0.46-0.50
C9orf46-0.45-0.54
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI18403135 
GO:0004553hydrolase activity, hydrolyzing O-glycosyl compoundsIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0005975carbohydrate metabolic processIEA-
GO:0007165signal transductionTAS9575201 
GO:0006633fatty acid biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACLYACL | ATPCL | CLATPATP citrate lyaseAffinity Capture-MSBioGRID17353931 
DHX36DDX36 | G4R1 | KIAA1488 | MLEL1 | RHAUDEAH (Asp-Glu-Ala-His) box polypeptide 36Affinity Capture-MSBioGRID17353931 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinAffinity Capture-MSBioGRID17353931 
F10FX | FXAcoagulation factor XTwo-hybridBioGRID16169070 
FNIP1DKFZp686E18167 | DKFZp781P0215 | KIAA1961 | MGC667folliculin interacting protein 1Affinity Capture-WesternBioGRID17028174 
GYS1GSY | GYSglycogen synthase 1 (muscle)Affinity Capture-MSBioGRID17353931 
MARSFLJ35667 | METRS | MTRNSmethionyl-tRNA synthetaseAffinity Capture-MSBioGRID17353931 
MYH10MGC134913 | MGC134914 | NMMHCBmyosin, heavy chain 10, non-muscleAffinity Capture-MSBioGRID17353931 
NDUFA7B14.5aNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDaTwo-hybridBioGRID16169070 
PRKAB2MGC61468protein kinase, AMP-activated, beta 2 non-catalytic subunitAffinity Capture-MSBioGRID17353931 
PRKAG1AMPKG | MGC8666protein kinase, AMP-activated, gamma 1 non-catalytic subunit-HPRD,BioGRID10698692 
PRKAG2AAKG | AAKG2 | CMH6 | H91620p | WPWSprotein kinase, AMP-activated, gamma 2 non-catalytic subunit-HPRD,BioGRID10698692 
SNRNP200ASCC3L1 | BRR2 | HELIC2 | U5-200KDsmall nuclear ribonucleoprotein 200kDa (U5)Affinity Capture-MSBioGRID17353931 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
BIOCARTA_LEPTIN_PATHWAY 1111All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE 1916All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 1513All SZGR genes in this pathway
REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 1815All SZGR genes in this pathway
REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 109All SZGR genes in this pathway
REACTOME_PKB_MEDIATED_EVENTS 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
KANNAN_TP53_TARGETS_UP 5840All SZGR genes in this pathway
WESTON_VEGFA_TARGETS_6HR 5938All SZGR genes in this pathway
WESTON_VEGFA_TARGETS 10871All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53 10963All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
NICK_RESPONSE_TO_PROC_TREATMENT_DN 2718All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN 193112All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_9 7645All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_UP 16697All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1377047101Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-539748754m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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