Gene Page: PRKAB2

Summary
GeneID  5565
Symbol  PRKAB2
Synonyms  MGC61468
Description  protein kinase, AMP-activated, beta 2 non-catalytic subunit
See related  HGNC:9379|MIM:602741|Ensembl:ENSG00000131791|HPRD:04117|
Locus tag  -
Gene type  protein-coding
Map location  1q21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MATR30.950.95
STX70.940.94
CAND10.940.95
FYTTD10.930.94
EXOC50.930.94
DNAJC180.930.92
UBE3A0.930.95
IPO70.930.94
SMEK20.920.92
ABCE10.920.93
Top 10 negatively co-expressed genes
FXYD1-0.70-0.87
AC018755.7-0.68-0.77
MT-CO2-0.67-0.82
AF347015.33-0.67-0.81
TSC22D4-0.66-0.78
AF347015.31-0.66-0.80
IFI27-0.66-0.82
HIGD1B-0.66-0.83
AIFM3-0.65-0.75
HEPN1-0.65-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS9575201 
GO:0006633fatty acid biosynthetic processIEA-
GO:0046320regulation of fatty acid oxidationEXP16054041 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP15060529 
GO:0005654nucleoplasmEXP10698692 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PRKAB1AMPK | HAMPKb | MGC17785protein kinase, AMP-activated, beta 1 non-catalytic subunitAffinity Capture-MSBioGRID17353931 
PRKAG1AMPKG | MGC8666protein kinase, AMP-activated, gamma 1 non-catalytic subunit-HPRD,BioGRID10698692 
PRKAG2AAKG | AAKG2 | CMH6 | H91620p | WPWSprotein kinase, AMP-activated, gamma 2 non-catalytic subunit-HPRD,BioGRID10698692 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
BIOCARTA_LEPTIN_PATHWAY 1111All SZGR genes in this pathway
REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE 1916All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 1513All SZGR genes in this pathway
REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 1815All SZGR genes in this pathway
REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 109All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_PKB_MEDIATED_EVENTS 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_DN 148102All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_DN 298200All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_UV 6243All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_UP 17496All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
LIN_NPAS4_TARGETS_UP 163100All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
CHANDRAN_METASTASIS_UP 221135All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA 208107All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-153332233281Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-217388638921Ahsa-miR-217UACUGCAUCAGGAACUGAUUGGAU
miR-25/32/92/363/367332433301Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-2942494255m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-3201671731Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-448332133281A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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