Gene Page: PTGS1

Summary
GeneID  5742
Symbol  PTGS1
Synonyms  COX1|COX3|PCOX1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHS
Description  prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
See related  HGNC:9604|MIM:176805|Ensembl:ENSG00000095303|HPRD:07518|
Locus tag  RP11-542K23.6
Gene type  protein-coding
Map location  9q32-q33.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM19A40.960.70
RGS160.950.37
GRID2IP0.940.29
NTNG10.920.81
TTC39A0.910.71
PAPPA0.910.44
KCNK130.910.69
SUSD20.910.28
CHRNA30.900.34
CLMN0.890.44
Top 10 negatively co-expressed genes
PLEKHO1-0.25-0.19
WDR86-0.24-0.26
SIGIRR-0.24-0.52
C6orf48-0.21-0.31
EMID1-0.21-0.17
NR2C2AP-0.21-0.13
RBMX2-0.21-0.36
RPS20-0.21-0.46
NME4-0.20-0.52
RPS14-0.20-0.33
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004601peroxidase activityIEA-
GO:0005506iron ion bindingIEA-
GO:0004666prostaglandin-endoperoxide synthase activityTAS9630216 
GO:0020037heme bindingIEA-
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEA-
GO:0016491oxidoreductase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001516prostaglandin biosynthetic processISS-
GO:0008217regulation of blood pressureISS-
GO:0006979response to oxidative stressIEA-
GO:0006633fatty acid biosynthetic processIEA-
GO:0006629lipid metabolic processNAS1907252 
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeISS-
GO:0005794Golgi apparatusIDA18029348 
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIDA18029348 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
NUCB1DKFZp686A15286 | FLJ40471 | NUCnucleobindin 1Two-hybridBioGRID8643612 
PTGS1COX1 | COX3 | PCOX1 | PGG/HS | PGHS-1 | PGHS1 | PHS1 | PTGHSprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)COX-1 forms a homodimer. This interaction was modelled on a demonstrated homodimerization of sheep COX-1.BIND11318639 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ARACHIDONIC_ACID_METABOLISM 5836All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
REACTOME_BIOLOGICAL_OXIDATIONS 13991All SZGR genes in this pathway
REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS 7050All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP 255177All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_DN 3924All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_UP 182110All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
ODONNELL_TARGETS_OF_MYC_AND_TFRC_UP 8350All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_MODERATELY_DN 11064All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_UP 14085All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_SUBSET 3320All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 7151All SZGR genes in this pathway
ROSS_AML_OF_FAB_M7_TYPE 6844All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
GREENBAUM_E2A_TARGETS_UP 3318All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C6 3927All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_UP 7848All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_DN 4628All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP 8959All SZGR genes in this pathway
LY_AGING_MIDDLE_UP 1411All SZGR genes in this pathway
BURTON_ADIPOGENESIS_7 5134All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
STEARMAN_TUMOR_FIELD_EFFECT_UP 3622All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_UP 12589All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP 10767All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_DN 1714All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3 12683All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3 13785All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_8 4936All SZGR genes in this pathway
LY_AGING_OLD_UP 75All SZGR genes in this pathway
RAGHAVACHARI_PLATELET_SPECIFIC_GENES 7046All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_C 9260All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_DN 1710All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway


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