Gene Page: TRIB3

Summary
GeneID  57761
Symbol  TRIB3
Synonyms  C20orf97|NIPK|SINK|SKIP3|TRB3
Description  tribbles homolog 3 (Drosophila)
See related  HGNC:16228|MIM:607898|Ensembl:ENSG00000101255|HPRD:09836|
Locus tag  RP5-1103G7.7
Gene type  protein-coding
Map location  20p13-p12.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0156 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003714transcription corepressor activityISS-
GO:0005515protein bindingIPI12743605 
GO:0005515protein bindingISS-
GO:0005524ATP bindingIEA-
GO:0004860protein kinase inhibitor activityIEA-
GO:0004672protein kinase activityIEA-
GO:0019901protein kinase bindingIPI15299019 
GO:0019901protein kinase bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0006469negative regulation of protein kinase activityISS-
GO:0006950response to stressIEA-
GO:0006915apoptosisIEA-
GO:0043405regulation of MAP kinase activityIDA15299019 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Affinity Capture-Western
Reconstituted Complex		BioGRID12791994 
ATF4CREB-2 | CREB2 | TAXREB67 | TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)-HPRD,BioGRID12743605 
SKIP3 interacts with ATF4.BIND12743605 
C7orf64DKFZP564O0523 | DKFZp686D1651 | HSPC304chromosome 7 open reading frame 64Two-hybridBioGRID16169070 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)Two-hybridBioGRID16169070 
DDIT3CEBPZ | CHOP | CHOP10 | GADD153 | MGC4154DNA-damage-inducible transcript 3TRIB3 (TRB3) interacts with DDIT3 (CHOP).BIND15775988 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 
GDF9-growth differentiation factor 9Two-hybridBioGRID16169070 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1Two-hybridBioGRID16169070 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5Two-hybridBioGRID16169070 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-WesternBioGRID12736262 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK 95All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION 3226All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 6348All SZGR genes in this pathway
REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING 2218All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 2920All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_UP 5238All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
NOJIMA_SFRP2_TARGETS_UP 3123All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLACK_UP 3522All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN 153100All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_UP 2921All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_DN 2212All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_UP 76All SZGR genes in this pathway
RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_MAPK1_DN 86All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
AIYAR_COBRA1_TARGETS_UP 3925All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_MCF10A 4326All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_UP 4529All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_UP 6647All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
AFFAR_YY1_TARGETS_DN 234137All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_DN 1814All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_0HR 6348All SZGR genes in this pathway
TSENG_IRS1_TARGETS_UP 11371All SZGR genes in this pathway
TSENG_ADIPOGENIC_POTENTIAL_UP 3019All SZGR genes in this pathway
KRIGE_AMINO_ACID_DEPRIVATION 2920All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_DN 10567All SZGR genes in this pathway
HELLER_HDAC_TARGETS_DN 292189All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN 281179All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_DN 2116All SZGR genes in this pathway
HANN_RESISTANCE_TO_BCL2_INHIBITOR_DN 4831All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_DN 12775All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_UP 14798All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
WANG_NEOPLASTIC_TRANSFORMATION_BY_CCND1_MYC 2114All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
LU_EZH2_TARGETS_UP 295155All SZGR genes in this pathway
WANG_ADIPOGENIC_GENES_REPRESSED_BY_SIRT1 2821All SZGR genes in this pathway
LI_DCP2_BOUND_MRNA 8957All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_UP 217131All SZGR genes in this pathway
WIERENGA_STAT5A_TARGETS_GROUP1 13676All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_UP 11265All SZGR genes in this pathway
PARK_OSTEOBLAST_DIFFERENTIATION_BY_PHENYLAMIL_UP 1311All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50694100m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-1824644701Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-964634701A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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