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Gene Page: RAC1

Summary

GeneID

5879

Symbol

RAC1

Synonyms

MGC111543|MIG5|TC-25|p21-Rac1

Description

ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

See related

HGNC:9801|MIM:602048|Ensembl:ENSG00000136238|HPRD:03627|

Locus tag

-

Gene type

protein-coding

Map location

7p22

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.2217

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SPIRE1

0.91

0.95

SLAIN2

0.90

0.91

NELL2

0.89

0.88

RLBP1L1

0.89

0.89

NCOA2

0.89

0.94

ACVR1B

0.89

0.93

LASS6

0.88

0.93

KBTBD7

0.88

0.93

HERC3

0.88

0.92

ZNF238

0.88

0.89

Top 10 negatively co-expressed genes

FXYD1

-0.67

-0.84

SERPINB6

-0.65

-0.72

HSD17B14

-0.64

-0.76

MT-CO2

-0.64

-0.82

AF347015.31

-0.64

-0.80

S100B

-0.62

-0.77

AF347015.33

-0.62

-0.77

TSC22D4

-0.62

-0.73

HEPN1

-0.62

-0.71

AIFM3

-0.62

-0.71

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

nucleotide binding

IEA

-

GTPase activity

TAS

GTP binding

IEA

-

enzyme binding

IPI

GTP-dependent protein binding

IPI

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

cell adhesion

TAS

anatomical structure morphogenesis

TAS

regulation of hydrogen peroxide metabolic process

TAS

inflammatory response

TAS

cell motion

TAS

small GTPase mediated signal transduction

IEA

-

positive regulation of Rho protein signal transduction

TAS

ruffle organization

TAS

negative regulation of receptor-mediated endocytosis

TAS

actin filament polymerization

TAS

lamellipodium biogenesis

IMP

localization within membrane

IMP

regulation of respiratory burst

IDA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

cytosol

EXP

7744773 |10648409 |14737186

intracellular

IEA

-

plasma membrane

IEA

-

melanosome

IEA

-

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	-	HPRD	11027608
ACTB	PS1TP5BP1	actin, beta	-	HPRD,BioGRID	11027608
ARFIP2	POR1	ADP-ribosylation factor interacting protein 2	Co-crystal Structure Reconstituted Complex Two-hybrid	BioGRID	8670882 \|11346801 \|11478794
ARFIP2	POR1	ADP-ribosylation factor interacting protein 2	-	HPRD	8670882 \|11478794
ARHGAP15	BM046	Rho GTPase activating protein 15	-	HPRD,BioGRID	12650940
ARHGAP17	DKFZp564A1363 \| FLJ37567 \| FLJ43368 \| MGC87805 \| MST066 \| MST110 \| MSTP038 \| MSTP066 \| MSTP110 \| NADRIN \| RICH1 \| WBP15	Rho GTPase activating protein 17	Biochemical Activity	BioGRID	11431473
ARHGAP27	CAMGAP1 \| FLJ43547 \| MGC120624	Rho GTPase activating protein 27	Biochemical Activity	BioGRID	15147912
ARHGAP8	BPGAP1 \| FLJ20185 \| PP610	Rho GTPase activating protein 8	BPGAP1 interacts with Rac1.	BIND	12944407
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD	10346909 \|10673424\|11513579
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD,BioGRID	10673424
ARHGDIB	D4 \| GDIA2 \| GDID4 \| LYGDI \| Ly-GDI \| RAP1GN1 \| RhoGDI2	Rho GDP dissociation inhibitor (GDI) beta	-	HPRD,BioGRID	9799233
ARHGDIG	RHOGDI-3	Rho GDP dissociation inhibitor (GDI) gamma	Rac1 interacts with RhoGDI.	BIND	14764880
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD,BioGRID	9857026 \|11595749
ARHGEF4	ASEF \| ASEF1 \| GEF4 \| STM6	Rho guanine nucleotide exchange factor (GEF) 4	Reconstituted Complex	BioGRID	10947987
ARHGEF6	COOL2 \| Cool-2 \| KIAA0006 \| MRX46 \| PIXA \| alpha-PIX \| alphaPIX	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	ARHGEF6 (Cool-2) interacts with Rac1.	BIND	15649357
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	-	HPRD,BioGRID	11130076 \|12054568
CDC42	CDC42Hs \| G25K	cell division cycle 42 (GTP binding protein, 25kDa)	Two-hybrid	BioGRID	9427749
CDC42BPG	DMPK2 \| HSMDPKIN \| KAPPA-200 \| MRCKgamma	CDC42 binding protein kinase gamma (DMPK-like)	-	HPRD,BioGRID	15194684
CDC42SE1	SCIP1 \| SPEC1	CDC42 small effector 1	-	HPRD,BioGRID	10816584
CDC42SE2	FLJ21967 \| SPEC2	CDC42 small effector 2	Two-hybrid	BioGRID	10816584
CDGAP	KIAA1204 \| MGC138368 \| MGC138370	Cdc42 GTPase-activating protein	-	HPRD	9786927
CHN1	ARHGAP2 \| CHN \| DURS2 \| RHOGAP2	chimerin (chimaerin) 1	-	HPRD	8496137
CIT	CRIK \| KIAA0949 \| STK21	citron (rho-interacting, serine/threonine kinase 21)	Far Western	BioGRID	8543060
CLIP1	CLIP \| CLIP-170 \| CLIP170 \| CYLN1 \| MGC131604 \| RSN	CAP-GLY domain containing linker protein 1	Affinity Capture-Western	BioGRID	12110184
CYBA	p22-PHOX	cytochrome b-245, alpha polypeptide	-	HPRD	10486263
CYFIP1	FLJ45151 \| P140SRA-1 \| SHYC \| SRA1	cytoplasmic FMR1 interacting protein 1	-	HPRD	9417078
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	-	HPRD,BioGRID	15023524
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	DEF6 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human DEF6 and Rac1 from an unspecified species.	BIND	15023524
DIAPH1	DFNA1 \| DIA1 \| DRF1 \| FLJ25265 \| LFHL1 \| hDIA1	diaphanous homolog 1 (Drosophila)	-	HPRD	11590143
DMPK	DM \| DM1 \| DM1PK \| DMK \| MDPK \| MT-PK	dystrophia myotonica-protein kinase	Reconstituted Complex	BioGRID	10869570
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	Rac interacts with Dock180.	BIND	12134158
DOCK1	DOCK180 \| ced5	dedicator of cytokinesis 1	-	HPRD,BioGRID	9808620
DOCK2	FLJ46592 \| KIAA0209	dedicator of cytokinesis 2	-	HPRD,BioGRID	10559471
DOCK8	FLJ00026 \| FLJ00152 \| FLJ00346 \| MRD2 \| ZIR8	dedicator of cytokinesis 8	-	HPRD,BioGRID	15304341
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD	7738010
FHOD1	FHOS	formin homology 2 domain containing 1	-	HPRD,BioGRID	11590143
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	10051605
FMNL1	C17orf1 \| C17orf1B \| FHOD4 \| FMNL \| KW-13 \| MGC133052 \| MGC1894 \| MGC21878	formin-like 1	-	HPRD,BioGRID	10958683
GEFT	p63RhoGEF	RhoA/RAC/CDC42 exchange factor	-	HPRD,BioGRID	12547822
ICMT	HSTE14 \| MGC39955 \| MST098 \| MSTP098 \| PCCMT \| PCMT \| PPMT	isoprenylcysteine carboxyl methyltransferase	-	HPRD,BioGRID	12006387
IL1RAP	C3orf13 \| FLJ37788 \| IL-1RAcP \| IL1R3	interleukin 1 receptor accessory protein	-	HPRD,BioGRID	11416133
IQGAP1	HUMORFA01 \| KIAA0051 \| SAR1 \| p195	IQ motif containing GTPase activating protein 1	-	HPRD,BioGRID	8670801
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD,BioGRID	8702968 \|8756646\|8756646
IQGAP2	-	IQ motif containing GTPase activating protein 2	-	HPRD	8756646
KTN1	CG1 \| KIAA0004 \| KNT \| MGC133337 \| MU-RMS-40.19	kinectin 1 (kinesin receptor)	-	HPRD,BioGRID	8769096
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	Reconstituted Complex	BioGRID	9427749
MAP3K11	MGC17114 \| MLK-3 \| MLK3 \| PTK1 \| SPRK	mitogen-activated protein kinase kinase kinase 11	-	HPRD	9427749
MAP3K4	FLJ42439 \| KIAA0213 \| MAPKKK4 \| MEKK4 \| MTK1 \| PRO0412	mitogen-activated protein kinase kinase kinase 4	Reconstituted Complex	BioGRID	9079650
MCF2L	ARHGEF14 \| DBS \| FLJ12122 \| KIAA0362 \| OST	MCF.2 cell line derived transforming sequence-like	-	HPRD,BioGRID	7957046 \|14701795
METAP2	MAP2 \| MNPEP \| p67 \| p67eIF2	methionyl aminopeptidase 2	-	HPRD	7738010
MYD88	MYD88D	myeloid differentiation primary response gene (88)	Affinity Capture-Western Reconstituted Complex	BioGRID	11416133
NCF1C	SH3PXD1C	neutrophil cytosolic factor 1C pseudogene	-	HPRD	9255350
NCF2	FLJ93058 \| NCF-2 \| NOXA2 \| P67-PHOX \| P67PHOX	neutrophil cytosolic factor 2	-	HPRD	9255350 \|9624165 \|11896062\|11090627
			-	HPRD	7738010 \|8036496 \|9255350 \|9624165 \|11090627 \|11896062\|11090627
			Co-crystal Structure Reconstituted Complex	BioGRID	9624165 \|9642115 \|11090627
NCK1	MGC12668 \| NCK \| NCKalpha	NCK adaptor protein 1	-	HPRD	10766742
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD	9148763 \|9417078
NCKAP1	FLJ11291 \| HEM2 \| KIAA0587 \| MGC8981 \| NAP1 \| NAP125	NCK-associated protein 1	-	HPRD,BioGRID	9148763
NOS2	HEP-NOS \| INOS \| NOS \| NOS2A	nitric oxide synthase 2, inducible	-	HPRD	11422783 \|11457725
NOS2	HEP-NOS \| INOS \| NOS \| NOS2A	nitric oxide synthase 2, inducible	-	HPRD,BioGRID	11457725
NOXA1	FLJ25475 \| MGC131800 \| NY-CO-31 \| SDCCAG31 \| p51NOX	NADPH oxidase activator 1	-	HPRD	12716910
OPHN1	MRX60 \| OPN1	oligophrenin 1	-	HPRD,BioGRID	9582072 \|11998687
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between human PAK1 and Rac from Chinese hamster.	BIND	15975516
			PAK1 interacts with an unspecified isoform of Rac. This interaction was modeled on a demonstrated interaction between PAK1 from an unspecified species and human Rac.	BIND	15864311
			-	HPRD	7744004 \|8107774 \|11134022 \|11950930\|11134022
			Reconstituted Complex	BioGRID	12650940 \|12879077
			Active GTP-bound RAC1 interacts with PAK1B. This interaction was modelled on a demonstrated interaction between chicken RAC1 and human PAK1B.	BIND	15735674
			Rac1 interacts with Pak1. This interaction was modeled on a demonstrated interaction between Rac1 and Pak1 from an unspecified species.	BIND	15652748
			Rac1 interacts with Pak1. This interaction was modelled on a demonstrated interacton between Rac1 from an unspecified species and human Pak1.	BIND	12944407
PAK2	PAK65 \| PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2	-	HPRD,BioGRID	9535855
PAK3	CDKN1A \| MRX30 \| MRX47 \| OPHN3 \| PAK3beta \| bPAK \| hPAK3	p21 protein (Cdc42/Rac)-activated kinase 3	Reconstituted Complex Two-hybrid	BioGRID	11478794
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	Affinity Capture-Western	BioGRID	11756552
PAK7	KIAA1264 \| MGC26232 \| PAK5	p21 protein (Cdc42/Rac)-activated kinase 7	-	HPRD,BioGRID	11756552
PARD6A	PAR-6A \| PAR6 \| PAR6C \| PAR6alpha \| TAX40 \| TIP-40	par-6 partitioning defective 6 homolog alpha (C. elegans)	-	HPRD,BioGRID	11260256
PARD6G	FLJ45701 \| PAR-6G \| PAR6gamma	par-6 partitioning defective 6 homolog gamma (C. elegans)	-	HPRD,BioGRID	11260256
PARK2	AR-JP \| LPRS2 \| PDJ \| PRKN	Parkinson disease (autosomal recessive, juvenile) 2, parkin	Two-hybrid	BioGRID	16169070
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	7629060 \|8034624 \|12086876
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD	12086876
PLD1	-	phospholipase D1, phosphatidylcholine-specific	-	HPRD	11950936
PLEKHG2	CLG \| DKFZp667J2325 \| FLJ00018 \| FLJ22458 \| FLJ38638	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	-	HPRD,BioGRID	11839748
PLXNB1	KIAA0407 \| MGC149167 \| PLEXIN-B1 \| PLXN5 \| SEP	plexin B1	-	HPRD	12123608
PLXNB1	KIAA0407 \| MGC149167 \| PLEXIN-B1 \| PLXN5 \| SEP	plexin B1	Plexin-B1 interacts with Rac1. This interaction was modelled on a demonstrated interaction between human Plexin-B1 and Rac1 from an unspecified species.	BIND	15642257
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD,BioGRID	11284700
PTPLAD1	B-IND1 \| FLJ90376 \| HSPC121	protein tyrosine phosphatase-like A domain containing 1	-	HPRD,BioGRID	10747961
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	Reconstituted Complex	BioGRID	11134022
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	Rac1 interacts with RLIP76.	BIND	7673236
RALBP1	RIP1 \| RLIP1 \| RLIP76	ralA binding protein 1	-	HPRD,BioGRID	7673236
RAP1GDS1	GDS1 \| MGC118859 \| MGC118861 \| SmgGDS	RAP1, GTP-GDP dissociation stimulator 1	-	HPRD,BioGRID	11948427
RCC2	DKFZp762N0610 \| KIAA1470 \| TD-60	regulator of chromosome condensation 2	-	HPRD	12919680
RGL2	HKE1.5 \| KE1.5 \| RAB2L	ral guanine nucleotide dissociation stimulator-like 2	Two-hybrid	BioGRID	8939933
RICH2	KIAA0672 \| NPC-A-10	Rho-type GTPase-activating protein RICH2	Biochemical Activity	BioGRID	11431473
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Biochemical Activity	BioGRID	12454018 \|12819203
RPS6KB1	PS6K \| S6K \| S6K1 \| STK14A \| p70(S6K)-alpha \| p70-S6K \| p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1	-	HPRD	11438723
SH3BP1	-	SH3-domain binding protein 1	-	HPRD	10508610
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	11021801
SYNJ2	INPP5H \| KIAA0348 \| MGC44422	synaptojanin 2	-	HPRD,BioGRID	11084340
TBC1D3	TBC1D3A \| TRE17	TBC1 domain family, member 3	-	HPRD,BioGRID	12612085
TCF7L2	TCF-4 \| TCF4	transcription factor 7-like 2 (T-cell specific, HMG-box)	Rac1 interacts with TCF4.	BIND	15377999
TEC	MGC126760 \| MGC126762 \| PSCTK4	tec protein tyrosine kinase	Phenotypic Enhancement	BioGRID	11328862
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	The GTPase Rac1 specifically interacts with Dbl-homology domain of the nucleotide exchange factor TIAM1. This interaction is modelled on a demonstrated interaction between mouse TIAM1 and human Rac1.	BIND	11130063
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD,BioGRID	11130063 \|11595749
TNFRSF12A	CD266 \| FN14 \| TWEAKR	tumor necrosis factor receptor superfamily, member 12A	-	HPRD	14573547
TNFRSF12A	CD266 \| FN14 \| TWEAKR	tumor necrosis factor receptor superfamily, member 12A	Fn14 interacts with Rac1.	BIND	14573547
TRIO	FLJ42780 \| tgat	triple functional domain (PTPRF interacting)	-	HPRD,BioGRID	11595749
TUBA4A	FLJ30169 \| H2-ALPHA \| TUBA1	tubulin, alpha 4a	-	HPRD	8631991
VAV1	VAV	vav 1 guanine nucleotide exchange factor	Affinity Capture-Western	BioGRID	11287617
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD,BioGRID	10523675
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD,BioGRID	8643625
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	-	HPRD	9843499

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_WNT_SIGNALING_PATHWAY	151	112	All SZGR genes in this pathway
KEGG_AXON_GUIDANCE	129	103	All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY	76	53	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_ADHERENS_JUNCTION	75	53	All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	102	88	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY	75	56	All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	79	58	All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS	97	71	All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	118	78	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	216	144	All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	53	43	All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	68	44	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER	62	47	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER	70	56	All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS	73	58	All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY	36	31	All SZGR genes in this pathway
BIOCARTA_AT1R_PATHWAY	36	28	All SZGR genes in this pathway
BIOCARTA_BCR_PATHWAY	37	28	All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY	39	29	All SZGR genes in this pathway
BIOCARTA_SALMONELLA_PATHWAY	13	10	All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY	26	23	All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY	31	24	All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY	87	68	All SZGR genes in this pathway
BIOCARTA_P38MAPK_PATHWAY	40	31	All SZGR genes in this pathway
BIOCARTA_PTDINS_PATHWAY	23	16	All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY	27	24	All SZGR genes in this pathway
BIOCARTA_RAC1_PATHWAY	23	16	All SZGR genes in this pathway
BIOCARTA_RAS_PATHWAY	23	20	All SZGR genes in this pathway
BIOCARTA_NKCELLS_PATHWAY	20	13	All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY	19	17	All SZGR genes in this pathway
BIOCARTA_CDC42RAC_PATHWAY	16	13	All SZGR genes in this pathway
BIOCARTA_TCR_PATHWAY	49	37	All SZGR genes in this pathway
BIOCARTA_CREB_PATHWAY	27	25	All SZGR genes in this pathway
BIOCARTA_ARF_PATHWAY	17	13	All SZGR genes in this pathway
BIOCARTA_UCALPAIN_PATHWAY	18	11	All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY	20	14	All SZGR genes in this pathway
SA_B_CELL_RECEPTOR_COMPLEXES	24	20	All SZGR genes in this pathway
ST_MYOCYTE_AD_PATHWAY	27	25	All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY	63	52	All SZGR genes in this pathway
PID_BCR_5PATHWAY	65	50	All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY	23	17	All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY	66	53	All SZGR genes in this pathway
PID_P38_MKK3_6PATHWAY	26	21	All SZGR genes in this pathway
PID_WNT_NONCANONICAL_PATHWAY	32	26	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_S1P_S1P3_PATHWAY	29	24	All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY	40	38	All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY	31	29	All SZGR genes in this pathway
PID_ILK_PATHWAY	45	32	All SZGR genes in this pathway
PID_NECTIN_PATHWAY	30	20	All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY	31	25	All SZGR genes in this pathway
PID_CDC42_PATHWAY	70	51	All SZGR genes in this pathway
PID_RET_PATHWAY	39	29	All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	50	41	All SZGR genes in this pathway
PID_TXA2PATHWAY	57	43	All SZGR genes in this pathway
PID_S1P_S1P1_PATHWAY	21	18	All SZGR genes in this pathway
PID_NETRIN_PATHWAY	32	27	All SZGR genes in this pathway
PID_INTEGRIN_A9B1_PATHWAY	25	18	All SZGR genes in this pathway
PID_ARF6_DOWNSTREAM_PATHWAY	15	14	All SZGR genes in this pathway
PID_MTOR_4PATHWAY	69	55	All SZGR genes in this pathway
PID_CXCR4_PATHWAY	102	78	All SZGR genes in this pathway
PID_PI3KCI_PATHWAY	49	40	All SZGR genes in this pathway
PID_AJDISS_2PATHWAY	48	38	All SZGR genes in this pathway
PID_IL2_PI3K_PATHWAY	34	27	All SZGR genes in this pathway
PID_P75_NTR_PATHWAY	69	51	All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY	39	33	All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY	75	53	All SZGR genes in this pathway
PID_LIS1_PATHWAY	28	22	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_SYNDECAN_4_PATHWAY	32	25	All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY	42	30	All SZGR genes in this pathway
PID_ERBB2_ERBB3_PATHWAY	44	35	All SZGR genes in this pathway
PID_IL6_7_PATHWAY	47	40	All SZGR genes in this pathway
PID_ECADHERIN_KERATINOCYTE_PATHWAY	21	19	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
PID_NEPHRIN_NEPH1_PATHWAY	31	24	All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY	31	27	All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY	46	35	All SZGR genes in this pathway
PID_RAC1_REG_PATHWAY	38	25	All SZGR genes in this pathway
PID_ARF_3PATHWAY	19	13	All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY	30	25	All SZGR genes in this pathway
PID_NCADHERIN_PATHWAY	33	32	All SZGR genes in this pathway
PID_S1P_S1P2_PATHWAY	24	19	All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY	19	16	All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY	33	24	All SZGR genes in this pathway
PID_RAC1_PATHWAY	54	37	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES	113	81	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT	78	59	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION	120	77	All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK	43	33	All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	60	43	All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	81	61	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR	920	449	All SZGR genes in this pathway
REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE	31	25	All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE	251	188	All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS	74	56	All SZGR genes in this pathway
REACTOME_CD28_CO_STIMULATION	32	26	All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING	805	368	All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_RAC	14	11	All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION	15	14	All SZGR genes in this pathway
REACTOME_CD28_DEPENDENT_VAV1_PATHWAY	11	10	All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING	32	22	All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS	68	53	All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE	27	21	All SZGR genes in this pathway
REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION	13	9	All SZGR genes in this pathway
REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY	63	48	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ROBO_RECEPTOR	30	26	All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS	86	62	All SZGR genes in this pathway
REACTOME_NETRIN1_SIGNALING	41	30	All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1	34	25	All SZGR genes in this pathway
REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING	13	11	All SZGR genes in this pathway
REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION	132	101	All SZGR genes in this pathway
REACTOME_DSCAM_INTERACTIONS	11	10	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_HIV_INFECTION	207	122	All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS	132	81	All SZGR genes in this pathway
REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS	28	19	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_UP	73	50	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
TIMOFEEVA_GROWTH_STRESS_VIA_STAT1_DN	16	12	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP	305	185	All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN	260	143	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP	530	342	All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN	101	66	All SZGR genes in this pathway
LI_LUNG_CANCER	41	30	All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP	380	213	All SZGR genes in this pathway
CALVET_IRINOTECAN_SENSITIVE_VS_REVERTED_UP	5	5	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN	1024	594	All SZGR genes in this pathway
FRIDMAN_SENESCENCE_UP	77	60	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP	69	41	All SZGR genes in this pathway
WHITESIDE_CISPLATIN_RESISTANCE_UP	11	7	All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP	37	31	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_UP	21	16	All SZGR genes in this pathway
VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1	39	26	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_DN	88	58	All SZGR genes in this pathway
VERRECCHIA_RESPONSE_TO_TGFB1_C4	13	10	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN	366	257	All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP	91	63	All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP	84	60	All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES	389	245	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_IL3RA	9	6	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN	918	550	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	537	544	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-137	987	993	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-3p	747	754	1A,m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-144	538	544	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-182	308	315	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-194	127	133	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-200bc/429	715	721	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-361	1018	1025	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-485-3p	1493	1499	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-485-5p	466	472	m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-495	125	131	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-96	309	315	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-99/100	777	783	1A	hsa-miR-99a^brain	AACCCGUAGAUCCGAUCUUGUG
				hsa-miR-100^brain	AACCCGUAGAUCCGAACUUGUG
				hsa-miR-99b^brain	CACCCGUAGAACCGACCUUGCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

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