Gene Page: RAP1A

Summary
GeneID  5906
Symbol  RAP1A
Synonyms  KREV-1|KREV1|RAP1|SMGP21
Description  RAP1A, member of RAS oncogene family
See related  HGNC:9855|MIM:179520|Ensembl:ENSG00000116473|HPRD:01545|
Locus tag  -
Gene type  protein-coding
Map location  1p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityIEA-
GO:0003924GTPase activityTAS10777492 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI11022048 
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007264small GTPase mediated signal transductionIEA-
GO:0045786negative regulation of cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP16284401 
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APBB1IPINAG1 | PREL1 | RARP1 | RIAMamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein-HPRD15469846 
RIAM interacts with Rap1.BIND15469846 
ARHGEF1GEF1 | LBCL2 | LSC | P115-RHOGEF | SUB1.5Rho guanine nucleotide exchange factor (GEF) 1Biochemical ActivityBioGRID12581858 
BRAFB-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1v-raf murine sarcoma viral oncogene homolog B1Reconstituted ComplexBioGRID10454553 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1Affinity Capture-WesternBioGRID15854902 
GABARAPL2ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2GABA(A) receptor-associated protein-like 2Biochemical ActivityBioGRID12581858 
KRIT1CAM | CCM1KRIT1, ankyrin repeat containing-HPRD,BioGRID9285558 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD,BioGRID10224125 |10922060|10922060 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1Affinity Capture-WesternBioGRID11466412 
PDE6DPDEDphosphodiesterase 6D, cGMP-specific, rod, delta-HPRD,BioGRID11786539 
RABAC1PRA1 | PRAF1 | YIP3Rab acceptor 1 (prenylated)-HPRD11335720 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID7791872 |7862125 
|9867809 |10454553 
-HPRD7791872|9867809|10454553 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)Two-hybridBioGRID11786539 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulator-HPRD,BioGRID10085114 
Rap1A interacts with RalGDS. This interaction was modeled on a demonstrated interaction between human Rap1A and RalGDS from an unspecified species.BIND15856025 
RAP1GAPKIAA0474 | RAP1GA1 | Rap1GAP1 | rap1GAPIIRAP1 GTPase activating proteinBiochemical ActivityBioGRID12842888 
RAP1GDS1GDS1 | MGC118859 | MGC118861 | SmgGDSRAP1, GTP-GDP dissociation stimulator 1-HPRD,BioGRID11948427 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1Rap1A interacts with an unspecified isoform of C3G.BIND15856025 
RAPGEF2CNrasGEF | NRAPGEP | PDZ-GEF1 | PDZGEF1 | RA-GEF | Rap-GEPRap guanine nucleotide exchange factor (GEF) 2Biochemical Activity
Reconstituted Complex		BioGRID10934204 
RAPGEF3CAMP-GEFI | EPAC | EPAC1 | HSU79275 | MGC21410 | bcm910Rap guanine nucleotide exchange factor (GEF) 3Biochemical ActivityBioGRID10777494 
Rap1A interacts with Epac1.BIND15856025 
RAPGEF4CAMP-GEFII | CGEF2 | EPAC2 | Nbla00496Rap guanine nucleotide exchange factor (GEF) 4Biochemical ActivityBioGRID10777494 
Rap1A interacts with Epac2. This interaction was modeled on a demonstrated interaction between human Rap1A and mouse Epac2.BIND15856025 
RAPGEF5GFR | KIAA0277 | MR-GEF | REPACRap guanine nucleotide exchange factor (GEF) 5Rap1A interacts with Repac.BIND15856025 
Biochemical ActivityBioGRID10777494 |10934204 
RAPGEF6DKFZp667N084 | DKFZp686I15116 | KIA001LB | PDZ-GEF2 | PDZGEF2 | RA-GEF-2Rap guanine nucleotide exchange factor (GEF) 6-HPRD,BioGRID11524421 |12581858 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1in vivoBioGRID2164710 
RASGRP4-RAS guanyl releasing protein 4-HPRD11880369 
RASIP1FLJ20401 | RAINRas interacting protein 1-HPRD15031288 
RGL4MGC119678 | MGC119680 | Rgrral guanine nucleotide dissociation stimulator-like 4-HPRD,BioGRID12874025 
RGS14-regulator of G-protein signaling 14-HPRD,BioGRID10926822 
RHEBMGC111559 | RHEB2Ras homolog enriched in brainAffinity Capture-WesternBioGRID15854902 
RUNDC3ARAP2IP | RPIP8RUN domain containing 3AReconstituted ComplexBioGRID9523700 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-Western
Co-purification		BioGRID12147258 |12842888 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION 7057All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY 3730All SZGR genes in this pathway
ST_ERK1_ERK2_MAPK_PATHWAY 3225All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_REELIN_PATHWAY 2929All SZGR genes in this pathway
PID_NECTIN_PATHWAY 3020All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
PID_PI3KCI_PATHWAY 4940All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_IFNG_PATHWAY 4034All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_EPO_PATHWAY 3429All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS 1511All SZGR genes in this pathway
REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ 1510All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 4328All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_RAP1_SIGNALLING 1712All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_UP 10867All SZGR genes in this pathway
LIU_PROSTATE_CANCER_DN 481290All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_3D_DN 3119All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_DN 14383All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
SCHRAMM_INHBA_TARGETS_DN 2412All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP 5735All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_DN 2616All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C3 3624All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
GREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB 14583All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20672781Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-14923301A,m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-191541611A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-203.12993051Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-231271331Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-2421281A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/3672292351Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-26260266m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-299-5p6286341Ahsa-miR-299-5pUGGUUUACCGUCCCACAUACAU
miR-320677683m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-324-5p2943001Ahsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-330544550m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-4101181241Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-433-3p355361m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-539219225m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-5433063121Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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