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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: RAP1B

Summary

GeneID

5908

Symbol

RAP1B

Synonyms

DKFZp586H0723|K-REV|RAL1B

Description

RAP1B, member of RAS oncogene family

Locus tag

Gene type

protein-coding

Map location

12q14

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0069

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005525

GTP binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007264

small GTPase mediated signal transduction

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005622

intracellular

IEA

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
RAP1GAP	KIAA0474 \| RAP1GA1 \| Rap1GAP1 \| rap1GAPII	RAP1 GTPase activating protein	Rap1GAP interacts with Rap1	BIND	15141215
RASSF5	MGC10823 \| MGC17344 \| Maxp1 \| NORE1 \| NORE1A \| NORE1B \| RAPL \| RASSF3	Ras association (RalGDS/AF-6) domain family member 5	-	HPRD	9488663
RGL2	HKE1.5 \| KE1.5 \| RAB2L	ral guanine nucleotide dissociation stimulator-like 2	Reconstituted Complex Two-hybrid	BioGRID	8939933

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_CHEMOKINE_SIGNALING_PATHWAY	190	128	All SZGR genes in this pathway
KEGG_FOCAL_ADHESION	201	138	All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	118	78	All SZGR genes in this pathway
KEGG_LONG_TERM_POTENTIATION	70	57	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA	70	60	All SZGR genes in this pathway
BIOCARTA_EPHA4_PATHWAY	10	8	All SZGR genes in this pathway
BIOCARTA_MET_PATHWAY	37	30	All SZGR genes in this pathway
PID_MET_PATHWAY	80	60	All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY	40	38	All SZGR genes in this pathway
PID_NECTIN_PATHWAY	30	20	All SZGR genes in this pathway
PID_CXCR4_PATHWAY	102	78	All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY	39	33	All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY	41	32	All SZGR genes in this pathway
PID_IFNG_PATHWAY	40	34	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY	34	31	All SZGR genes in this pathway
PID_FAK_PATHWAY	59	45	All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS	79	48	All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	120	84	All SZGR genes in this pathway
REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS	15	11	All SZGR genes in this pathway
REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_	15	10	All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING	27	17	All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1	43	28	All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION	93	65	All SZGR genes in this pathway
REACTOME_RAP1_SIGNALLING	17	12	All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION	36	23	All SZGR genes in this pathway
REACTOME_HEMOSTASIS	466	331	All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM	933	616	All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	350	All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	208	138	All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_UP	201	125	All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP	255	177	All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP	305	185	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
LOPEZ_MBD_TARGETS	957	597	All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_12Q13_Q21_AMPLICON	46	21	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS	185	114	All SZGR genes in this pathway
DORSAM_HOXA9_TARGETS_UP	35	25	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	408	274	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
MA_PITUITARY_FETAL_VS_ADULT_DN	19	17	All SZGR genes in this pathway
LU_AGING_BRAIN_UP	262	186	All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN_DN	271	175	All SZGR genes in this pathway
WALLACE_PROSTATE_CANCER_DN	6	6	All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN	238	145	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN	784	464	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	66	72	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	965	971	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-101	965	971	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	1188	1194	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-128	835	842	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	835	842	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-139	824	830	1A	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-144	310	316	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-149	24	30	m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-181	977	983	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
				hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-19	155	162	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	155	162	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-194	1149	1155	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-200bc/429	1125	1131	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-217	1028	1034	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-23	974	980	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	974	980	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	22	29	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367	1203	1209	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
				hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-28	410	417	1A,m8	hsa-miR-28^brain	AAGGAGCUCACAGUCUAUUGAG
miR-30-5p	699	706	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-31	1277	1283	1A	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-329	728	734	1A	hsa-miR-329^brain	AACACACCUGGUUAACCUCUUU
miR-330	515	521	1A	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-339	1114	1120	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-378*	400	407	1A,m8	hsa-miR-422b	CUGGACUUGGAGUCAGAAGGCC
miR-378*	400	407	1A,m8	hsa-miR-422a	CUGGACUUAGGGUCAGAAGGCC
miR-381	1211	1217	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-485-3p	295	302	1A,m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-494	685	691	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	75	81	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	1175	1181	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	1175	1181	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-500	1202	1208	1A	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-9	404	410	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.