Gene Page: RAP2A

Summary
GeneID  5911
Symbol  RAP2A
Synonyms  K-REV|KREV|RAP2|RbBP-30
Description  RAP2A, member of RAS oncogene family
See related  HGNC:9861|MIM:179540|Ensembl:ENSG00000125249|HPRD:01547|
Locus tag  RP11-128N14.2
Gene type  protein-coding
Map location  13q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0384 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityTAS1900290 
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS3045729 
GO:0007264small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGAP29PARG1 | RP11-255E17.1Rho GTPase activating protein 29PARG1 interacts with Rap2.BIND15752761 
GABARAPL2ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2GABA(A) receptor-associated protein-like 2Biochemical ActivityBioGRID12581858 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD10862698 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD10224125 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Raf-1 interacts with Rap2. This interaction was modeled on a demonstrated interaction between Raf-1 from unspecified species and human Rap2.BIND15752761 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)Two-hybridBioGRID11786539 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulator-HPRD,BioGRID10085114 
RAPGEF3CAMP-GEFI | EPAC | EPAC1 | HSU79275 | MGC21410 | bcm910Rap guanine nucleotide exchange factor (GEF) 3Biochemical ActivityBioGRID10777494 
RAPGEF4CAMP-GEFII | CGEF2 | EPAC2 | Nbla00496Rap guanine nucleotide exchange factor (GEF) 4Biochemical ActivityBioGRID10777494 
RAPGEF5GFR | KIAA0277 | MR-GEF | REPACRap guanine nucleotide exchange factor (GEF) 5Biochemical ActivityBioGRID10777494 
RAPGEF6DKFZp667N084 | DKFZp686I15116 | KIA001LB | PDZ-GEF2 | PDZGEF2 | RA-GEF-2Rap guanine nucleotide exchange factor (GEF) 6-HPRD,BioGRID11524421 |12581858 
RASIP1FLJ20401 | RAINRas interacting protein 1-HPRD15031288 
RASSF5MGC10823 | MGC17344 | Maxp1 | NORE1 | NORE1A | NORE1B | RAPL | RASSF3Ras association (RalGDS/AF-6) domain family member 5-HPRD,BioGRID11857081 
RGS14-regulator of G-protein signaling 14-HPRD,BioGRID10926822 
RUNDC3ARAP2IP | RPIP8RUN domain containing 3A-HPRD,BioGRID9523700 
TNIK-TRAF2 and NCK interacting kinase-HPRD15342639 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
HOOI_ST7_TARGETS_DN 12378All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_DN 138All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
VALK_AML_CLUSTER_3 3312All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G12_UP 3917All SZGR genes in this pathway
SYED_ESTRADIOL_RESPONSE 1915All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_UP 207143All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN 10367All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10251257m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-124.1263826451A,m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506263826441Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-135885891m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-186267826841Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-203.1345034571A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-22333883394m8hsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-320105610621Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-326334733541A,m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-33348534921A,m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-330289228991A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-9266326691Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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