Gene Page: RB1

Summary
GeneID  5925
Symbol  RB1
Synonyms  OSRC|RB|p105-Rb|pRb|pp110
Description  retinoblastoma 1
See related  HGNC:9884|MIM:180200|Ensembl:ENSG00000139687|HPRD:01574|
Locus tag  -
Gene type  protein-coding
Map location  13q14.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0835 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SNX320.510.60
TCEAL50.500.52
PDZD40.490.54
PPP1R9B0.480.51
KIFC20.480.53
TCAP0.480.46
JAKMIP10.480.53
CCDC640.460.54
OGFR0.460.47
SPEG0.460.52
Top 10 negatively co-expressed genes
MYL12A-0.36-0.44
AP002478.3-0.32-0.35
TM4SF1-0.31-0.30
GIMAP5-0.31-0.31
TTC38-0.31-0.30
MAPKAPK3-0.31-0.35
GJA4-0.31-0.32
ICAM2-0.31-0.32
C1orf54-0.30-0.35
CLDN5-0.30-0.35
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND3413073 
GO:0003700transcription factor activityTAS3657987 
GO:0003713transcription coactivator activityNAS15572661 
GO:0008134transcription factor bindingIEA-
GO:0016564transcription repressor activityIEA-
GO:0019900kinase bindingIDA16286473 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000075cell cycle checkpointTAS10825186 
GO:0000082G1/S transition of mitotic cell cycleIEA-
GO:0000122negative regulation of transcription from RNA polymerase II promoterTAS9491888 
GO:0000279M phaseNAS7542657 
GO:0006355regulation of transcription, DNA-dependentNAS3413073 
GO:0006350transcriptionIEA-
GO:0006469negative regulation of protein kinase activityIPI9858607 
GO:0007050cell cycle arrestIEA-
GO:0008285negative regulation of cell proliferationIEA-
GO:0016568chromatin modificationIEA-
GO:0051146striated muscle cell differentiationIEA-
GO:0051318G1 phaseTAS7542657 
GO:0051301cell divisionIEA-
GO:0030308negative regulation of cell growthTAS7542657 
GO:0043353enucleate erythrocyte differentiationIEA-
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045651positive regulation of macrophage differentiationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045786negative regulation of cell cycleIEA-
GO:0043550regulation of lipid kinase activityIDA16286473 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000785chromatinTAS3657987 
GO:0005819spindleIEA-
GO:0005634nucleusNAS3413073 
GO:0005634nucleusTAS3657987 
GO:0005654nucleoplasmEXP9190208 |11931757 |14527418 
GO:0005667transcription factor complexIEA-
GO:0016605PML bodyIDA9448006 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AATFCHE-1 | CHE1 | DEDapoptosis antagonizing transcription factor-HPRD,BioGRID10783144 |12450794 
Che-1 interacts with Rb.BIND10783144 
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD7828850 |8242749 
Rb interacts with c-AblBIND9632788 
-HPRD,BioGRID8242749 
AHR-aryl hydrocarbon receptor-HPRD,BioGRID9712901 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorRb interacts with AR.BIND9675141 
-HPRD,BioGRID9675141 
ARID3BBDP | DRIL2AT rich interactive domain 3B (BRIGHT-like)-HPRD,BioGRID10446990 
ARID4ARBBP1 | RBP-1 | RBP1AT rich interactive domain 4A (RBP1-like)-HPRD,BioGRID10321733 |10490602 
ARNTHIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2aryl hydrocarbon receptor nuclear translocatorAffinity Capture-WesternBioGRID9712901 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2-HPRD,BioGRID1641004 
Rb interacts with ATF2. This interaction was modelled on a demonstrated interaction between Rb from an unspecified species and ATF2 from an unspecified species.BIND11566021 
BAG1RAP46BCL2-associated athanogeneAffinity Capture-WesternBioGRID12845674 
BCRALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHLbreakpoint cluster regionAffinity Capture-WesternBioGRID9071815 
BDP1DKFZp686C01233 | DKFZp686K0831 | HSA238520 | KIAA1241 | KIAA1689 | TAF3B1 | TFC5 | TFIIIB'' | TFIIIB150 | TFIIIB90 | TFNRB double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBRb interacts with TFIIIB90BIND9169441 
BGLAPBGP | OC | PMF1bone gamma-carboxyglutamate (gla) proteinpRB interacts with OC promoter.BIND15949438 
BIRC5API4 | EPR-1baculoviral IAP repeat-containing 5RB1 (pRB) interacts with the BIRC5 (survivin) promoter.BIND15271987 
BNC2BSN2 | DKFZp686A01127 | FLJ20043 | FLJ34928basonuclin 2pRB interacts with BAA90908.BIND15949438 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10220405 
BRCA1 interacts with Rb.BIND10518542 
BRD2D6S113E | DKFZp686N0336 | FLJ31942 | FSH | FSRG1 | KIAA9001 | NAT | RING3 | RNF3bromodomain containing 2pRB interacts with BRD2 promoter.BIND15949438 
BRD8SMAP | SMAP2 | p120bromodomain containing 8pRB interacts with BRD8 promoter.BIND15949438 
BRF1BRF | FLJ42674 | FLJ43034 | GTF3B | MGC105048 | TAF3B2 | TAF3C | TAFIII90 | TF3B90 | TFIIIB90 | hBRFBRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)Affinity Capture-WesternBioGRID11997511 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseCASP10 (caspase-10) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form.BIND15735701 
CASP2CASP-2 | ICH-1L | ICH-1L/1S | ICH1 | NEDD2caspase 2, apoptosis-related cysteine peptidaseCASP2 (caspase-2) cleaves RB-1 (hRB) at the DEAD consensus site into the p100 form.BIND15735701 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseCASP3 (caspase-3) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p100, p68, p61 and p48 forms.BIND15735701 
CASP6MCH2caspase 6, apoptosis-related cysteine peptidaseCASP6 (caspase-6) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form.BIND15735701 
CASP7CMH-1 | ICE-LAP3 | MCH3caspase 7, apoptosis-related cysteine peptidaseCASP7 (caspase-7) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p68, p61 and p48 forms.BIND15735701 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseCASP8 (caspase-8) cleaves RB-1 (hRB) into the p68 form and to a lesser extent the p61 form.BIND15735701 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidaseCASP9 (caspase-9) cleaves RB-1 (hRB) at the LEND consensus site to produce the p76 form.BIND15735701 
CBX1CBX | HP1-BETA | HP1Hs-beta | HP1Hsbeta | M31 | MOD1 | p25betachromobox homolog 1 (HP1 beta homolog Drosophila )Reconstituted ComplexBioGRID12711675 
CBX4NBP16 | PC2 | hPC2chromobox homolog 4 (Pc class homolog, Drosophila)-HPRD,BioGRID11583618 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)Affinity Capture-WesternBioGRID11484059 
CCNA1-cyclin A1-HPRD,BioGRID10022926 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1Rb interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between Cyclin D1 from mouse and Rb from human.BIND11126356 
-HPRD,BioGRID8490963 
CCND3-cyclin D3Two-hybridBioGRID17972097 
CCNT2FLJ90560 | MGC134840cyclin T2-HPRD,BioGRID12037672 
CDK2p33(CDK2)cyclin-dependent kinase 2CDK2 phosphorylates Rb carboxy-terminus.BIND15241418 
Biochemical ActivityBioGRID10938106 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4CDK4 phosphorylates Rb carboxy-terminus. This interaction was modelled on a demonstrated interaction between human Rb and mouse CDK4.BIND15241418 
CDK6MGC59692 | PLSTIRE | STQTL11cyclin-dependent kinase 6CDK6 phosphorylates Rb. This interaction was modeled on a demonstrated interaction between CDK6 and Rb, both from an unspecified species.BIND7629134 
Cdk6 phosphorylates RbBIND10339564 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9Affinity Capture-Western
Reconstituted Complex
BioGRID12037672 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)Rb interacts with the p21 promoter.BIND15716956 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD,BioGRID11596110 
CEBPDC/EBP-delta | CELF | CRP3 | NF-IL6-betaCCAAT/enhancer binding protein (C/EBP), deltaC/EBP-delta interacts with Rb.BIND15674331 
CEBPEC/EBP-epsilon | CRP1CCAAT/enhancer binding protein (C/EBP), epsilonRb interacts with C/EBPepsilon.BIND12947005 
CREG1CREGcellular repressor of E1A-stimulated genes 1-HPRD,BioGRID9710587 
CTBP1BARS | MGC104684C-terminal binding protein 1-HPRD11583618 
CUX1CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75cut-like homeobox 1-HPRD,BioGRID12891711 
DNMT1AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992DNA (cytosine-5-)-methyltransferase 1Rb interacts with hDnmt1.BIND11847125 
-HPRD,BioGRID10888886 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alphaReconstituted ComplexBioGRID11350943 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1pRB interacts with E2F-1.BIND15949438 
pRB interacts with E2F1.BIND8816797 |8816798 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID7739537 |8230483 
|8896460 |9422723 
|10869426 |11470869 
|12397079 
pRb interacts with E2F1.BIND15619620 
E2F1 (RBP3) interacts with pRB.BIND1638634 
-HPRD1388726 |11583618 
Rb interacts with E2F-1.BIND8346196 
Rb interacts with E2FBIND9632788 
E2F2E2F-2E2F transcription factor 2E2F-2 interacts with pRb.BIND8246996 
-HPRD,BioGRID12502741 
E2F1 interacts with pRb.BIND8246996 
pRB interacts with E2F-2.BIND15949438 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingTwo-hybridBioGRID10869426 
-HPRD8657117 
E4F1E4F | MGC99614E4F transcription factor 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID10869426 
EID1C15orf3 | CRI1 | EID-1 | IRO45620 | MGC138883 | MGC138884 | PNAS-22 | PTD014 | RBP21EP300 interacting inhibitor of differentiation 1pRB interacts with EID-1.BIND15949438 
RB1 (pRb) interacts with CRI1 (EID-1).BIND15806172 
-HPRD,BioGRID11073989 |11073990 
ELF1-E74-like factor 1 (ets domain transcription factor)-HPRD8493578 
ENC1CCL28 | ENC-1 | FLJ39259 | KLHL35 | KLHL37 | NRPB | PIG10 | TP53I10ectodermal-neural cortex (with BTB-like domain)-HPRD,BioGRID9566959 
EPOEP | MGC138142erythropoietinRB1 (pRB) interacts with the EPO gene 3(prime) enhancer.BIND15674338 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD8475068 
FRKGTK | PTK5 | RAKfyn-related kinase-HPRD,BioGRID7664264 
pRB interacts with Rak.BIND7664264 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID12761493 
RACK1 interacts with RbBIND12761493 
GTF3C2KIAA0011 | TFIIIC-BETA | TFIIIC110general transcription factor IIIC, polypeptide 2, beta 110kDaRb interacts with TFIIIC2BIND9169441 
HBP1FLJ16340HMG-box transcription factor 1-HPRD,BioGRID9178770 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1RB interacts with HDAC1.BIND11447271 
-HPRD9491888 |10888886 
|11896613 |11909966 
The Retinoblastoma protein interacts with Histone Deacetylase 1.BIND10734134 
Affinity Capture-Western
Reconstituted Complex
BioGRID9491888 |9724731 
|10490602 |10615135 
|10779361 |11684023 
|12466959 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-WesternBioGRID10490602 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3-HPRD,BioGRID12479814 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)RB1 (pRB) interacts with HIF1A (HIF-1-alpha).BIND15674338 
HMGB1DKFZp686A04236 | HMG1 | HMG3 | SBP-1high-mobility group box 1HMGB1 interacts with RB1 (pRB). This interaction was modelled on a demonstrated interaction between rat HMGB1 and human RB1 (pRB).BIND11748221 
-HPRD,BioGRID11748221 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD7673249 
JARID1AKDM5A | RBBP2 | RBP2jumonji, AT rich interactive domain 1A-HPRD,BioGRID7935440 
Rbp2 interacts with Rb. This interaction was modeled on a demonstrated interaction between human Rbp2 and Rb from an unspecified species.BIND11358960 
pRB interacts with RBP2.BIND15949438 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID10026157 
RB interacts with c-Jun.BIND10026157 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BpRb interacts with the acetyltransferase domain of P/CAF.BIND15044952 
LIN37F25965 | MGC9505 | ZK418.4 | lin-37lin-37 homolog (C. elegans)pRb interacts with hMip40.BIND15479636 
LIN54CXCDC1 | DKFZp686L1814 | JC8.6 | MGC129905 | MIP120lin-54 homolog (C. elegans)pRb interacts with hMip120.BIND15479636 
LIN9BARA | BARPsv | Lin-9 | TGS | TGS1lin-9 homolog (C. elegans)pRb interacts with hMip130/TWIT.BIND15479636 
-HPRD,BioGRID15538385 
LMNACDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | PRO1lamin A/C-HPRD,BioGRID8058329 |8278403 
Rb interacts with lamin CBIND12475961 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1RB1 is phosphorylated by MAPK1. This interaction was modeled on a demonstrated interaction between human KIAA1536 and MAPK1 from an unspecified species.BIND15489336 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9Rb interacts with JNK2. This interaction was modelled on a demonstrated interaction between Rb from an unspecified species and JNK2 from an unspecified species.BIND11566021 
MCM7CDABP0042 | CDC47 | MCM2 | P1.1-MCM3 | P1CDC47 | P85MCM | PNAS-146minichromosome maintenance complex component 7-HPRD,BioGRID9566894 
MCM7 interacts with Rb.BIND9566894 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD,BioGRID7791904|10078201 |10721693 
Rb interacts with Mdm2.BIND15577944 
Rb interacts with MDM2.BIND15485814 
MDM4DKFZp781B1423 | HDMX | MDMX | MGC132766 | MRP1Mdm4 p53 binding protein homolog (mouse)pRb interacts with MDMX. This interaction was modeled on a demonstrated interaction between mouse MDMX and human pRb.BIND12532331 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factorAn unspecified isoform of Mitf interacts with Rb.BIND15716956 
MNAT1MAT1 | RNF66 | TFB3menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)-HPRD,BioGRID11113200 
MORF4L1Eaf3 | FWP006 | HsT17725 | MGC10631 | MORFRG15 | MRG15 | S863-6mortality factor 4 like 1-HPRD,BioGRID11500496 |12397079 
MORF4L2KIAA0026 | MORFL2 | MRGXmortality factor 4 like 2-HPRD,BioGRID14506250 
MRFAP1PAM14 | PGR1Mof4 family associated protein 1Affinity Capture-Western
Co-purification
BioGRID11500496 |12397079 
MT1GMGC12386 | MT1 | MT1Kmetallothionein 1GRB1 interacts with the MT1G promoter.BIND15735762 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID7838535 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD,BioGRID8381715 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Rb interacts with ASC-2.BIND14645241 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID14645241 
NDC80HEC | HEC1 | KNTC2 | TID3 | hsNDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)-HPRD,BioGRID10409732 
NFIXNF1Anuclear factor I/X (CCAAT-binding transcription factor)Affinity Capture-WesternBioGRID11896613 
PA2G4EBP1 | HG4-1 | p38-2G4proliferation-associated 2G4, 38kDa-HPRD,BioGRID11268000 
PAX6AN | AN2 | D11S812E | MGC17209 | MGDA | WAGRpaired box 6Reconstituted ComplexBioGRID10359315 
PELP1HMX3 | MNAR | P160proline, glutamate and leucine rich protein 1-HPRD,BioGRID12682072 
PELP1 interacts with pRb.BIND12682072 
PHBPHB1prohibitin-HPRD,BioGRID10376528 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Rb interacts with p55alphaBIND12588990 
PIK3R3DKFZp686P05226 | FLJ41892 | p55 | p55-GAMMAphosphoinositide-3-kinase, regulatory subunit 3 (gamma)-HPRD,BioGRID12588990 
Rb interacts with PI3K regulatory subunit p55gammaBIND12588990 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID9448006 
POLA1DKFZp686K1672 | POLA | p180polymerase (DNA directed), alpha 1, catalytic subunit-HPRD,BioGRID9395244 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gammaAffinity Capture-Western
Reconstituted Complex
BioGRID12479814 
PPIACYPA | CYPH | MGC117158 | MGC12404 | MGC23397peptidylprolyl isomerase A (cyclophilin A)Rb interacts with CypA.BIND12210730 
PRDM2HUMHOXY1 | KMT8 | MTB-ZF | RIZ | RIZ1 | RIZ2PR domain containing 2, with ZNF domain-HPRD,BioGRID7538672 
PRKRADYT16 | HSD14 | PACT | RAXprotein kinase, interferon-inducible double stranded RNA dependent activator-HPRD,BioGRID9010216 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID9819434 
Raf-1 interacts with Rb.BIND9819434 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD12502741 
RBAKZNF769RB-associated KRAB zinc finger-HPRD10702291 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4The retinoblastoma protein 1 (Rb) interacts with RbAp48BIND7503932 
-HPRD,BioGRID7503932 
RBBP5RBQ3 | SWD1retinoblastoma binding protein 5-HPRD,BioGRID7558034 
RBBP7MGC138867 | MGC138868 | RbAp46retinoblastoma binding protein 7-HPRD,BioGRID7503932 
The retinoblastoma protein, Rb, interacts with RbAp46.BIND7503932 
RBBP8CTIP | RIMretinoblastoma binding protein 8-HPRD,BioGRID9721205 
RBBP9BOG | MGC9236 | RBBP10retinoblastoma binding protein 9-HPRD,BioGRID9697699 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)Rb interacts with the p107 promoter.BIND15716956 
Affinity Capture-WesternBioGRID10490602 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)Affinity Capture-WesternBioGRID10490602 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDaAffinity Capture-WesternBioGRID10353443 
RING1RING1A | RNF1ring finger protein 1-HPRD,BioGRID11583618 
RUNX2AML3 | CBFA1 | CCD | CCD1 | MGC120022 | MGC120023 | OSF2 | PEA2aA | PEBP2A1 | PEBP2A2 | PEBP2aA | PEBP2aA1runt-related transcription factor 2Runx2 interacts with pRb.BIND15583032 
SERPINB2HsT1201 | PAI | PAI-2 | PAI2 | PLANH2serpin peptidase inhibitor, clade B (ovalbumin), member 2-HPRD,BioGRID12944478 
Rb interacts with PAI-2.BIND12944478 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)Skp2 interacts with Rb.BIND15469821 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID7923370 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1-HPRD11085541 
SNAPC1PTFgamma | SNAP43small nuclear RNA activating complex, polypeptide 1, 43kDaRb interacts with SNAP43BIND11094070 
Affinity Capture-Western
Reconstituted Complex
BioGRID11094070 
SNAPC3MGC132011 | MGC33124 | PTFbeta | SNAP50small nuclear RNA activating complex, polypeptide 3, 50kDaRb interacts with SNAP50BIND11094070 
-HPRD,BioGRID11094070 
SNW1Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIPSNW domain containing 1Reconstituted ComplexBioGRID12466551 
SP1-Sp1 transcription factor-HPRD7732011 
Affinity Capture-WesternBioGRID11896613 
SP3DKFZp686O1631 | SPR-2Sp3 transcription factor-HPRD7732011 
SPIBSPI-BSpi-B transcription factor (Spi-1/PU.1 related)-HPRD10196196 
SUV39H1KMT1A | MG44 | SUV39Hsuppressor of variegation 3-9 homolog 1 (Drosophila)-HPRD,BioGRID11484059 |11533237 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDaTAFII250 interacts with Rb.BIND11126356 
-HPRD,BioGRID7724524 |9242374 
|9858607 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding proteinRb interacts with TBPBIND11094070 
TFDP1DP1 | DRTF1 | Dp-1transcription factor Dp-1Affinity Capture-WesternBioGRID7739537 
TFDP2DP2 | Dp-2transcription factor Dp-2 (E2F dimerization partner 2)Affinity Capture-WesternBioGRID7739537 
TGM2G-ALPHA-h | GNAH | TG2 | TGCtransglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)-HPRD,BioGRID9315663 
THOC1HPR1 | P84 | P84N5THO complex 1-HPRD,BioGRID7525595 
TMPOCMD1T | LAP2 | LEMD4 | MGC61508 | PRO0868 | TPthymopoietinRb interacts with LAP2alphaBIND12475961 
-HPRD,BioGRID12475961 
TP73P73tumor protein p73Affinity Capture-WesternBioGRID12761493 
TRAP1HSP75 | HSP90LTNF receptor-associated protein 1-HPRD,BioGRID8756626 
TRIP11CEV14 | GMAP-210 | TRIP230thyroid hormone receptor interactor 11-HPRD,BioGRID9256431 
TYROCA1A | OCAIA | SHEP3tyrosinase (oculocutaneous albinism IA)Rb interacts with the TYR promoter.BIND15716956 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)RB1 (pRb) interacts with, and is sumoylated by, an unspecified isoform of UBE2I (Ubc9).BIND15806172 
UBTFNOR-90 | UBFupstream binding transcription factor, RNA polymerase I-HPRD,BioGRID11042686 
VDRNR1I1vitamin D (1,25- dihydroxyvitamin D3) receptorReconstituted ComplexBioGRID11358960 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor ARB1 (pRB) interacts with the VEGF promoter.BIND15674338 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16pRB interacts with PLZF.BIND15949438 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_MELANOMA 7157All SZGR genes in this pathway
KEGG_BLADDER_CANCER 4233All SZGR genes in this pathway
KEGG_CHRONIC_MYELOID_LEUKEMIA 7359All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_TID_PATHWAY 1915All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_SKP2E2F_PATHWAY 106All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_HCMV_PATHWAY 1716All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_P53_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_RB_PATHWAY 1311All SZGR genes in this pathway
BIOCARTA_P27_PATHWAY 1310All SZGR genes in this pathway
BIOCARTA_PML_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_TEL_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_ARF_PATHWAY 1713All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 6737All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_G1_PHASE 3823All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 136All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN 6642All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_DN 11878All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN 2915All SZGR genes in this pathway
MARKS_ACETYLATED_NON_HISTONE_PROTEINS 159All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HBZ 4127All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_HEMGN 3121All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_XPRSS_INT_NETWORK 168103All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
PUJANA_BRCA_CENTERED_NETWORK 11772All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
FRIDMAN_IMMORTALIZATION_DN 3424All SZGR genes in this pathway
HE_PTEN_TARGETS_UP 1615All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_7 2722All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_DN 3121All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_FREQUENTLY 1210All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
PENG_GLUCOSE_DEPRIVATION_DN 169112All SZGR genes in this pathway
REN_BOUND_BY_E2F 6140All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGLL_VS_IGLK_UP 4224All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
HASLINGER_B_CLL_WITH_13Q14_DELETION 2418All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_UP 3929All SZGR genes in this pathway
KUMAR_TARGETS_OF_MLL_AF9_FUSION 405264All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_24HR 5538All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
DELASERNA_MYOD_TARGETS_UP 8951All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_UP 8251All SZGR genes in this pathway
ZHU_CMV_24_HR_UP 9365All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
CHENG_IMPRINTED_BY_ESTRADIOL 11068All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA 5135All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
MCMURRAY_TP53_HRAS_COOPERATION_RESPONSE_DN 6746All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP 3225All SZGR genes in this pathway
ISHIDA_E2F_TARGETS 5327All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_MUTATED 88All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
KUROKAWA_LIVER_CANCER_EARLY_RECURRENCE_DN 76All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
BRIDEAU_IMPRINTED_GENES 6347All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/986866921Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-14399910051Ahsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-17-5p/20/93.mr/106/519.d883889m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-192/215158215891A,m8hsa-miR-192CUGACCUAUGAAUUGACAGCC
hsa-miR-215AUGACCUAUGAAUUGACAGAC
miR-334564621Ahsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-7106310701A,m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.