Gene Page: REL

Summary
GeneID  5966
Symbol  REL
Synonyms  C-Rel
Description  v-rel reticuloendotheliosis viral oncogene homolog (avian)
See related  HGNC:9954|MIM:164910|Ensembl:ENSG00000162924|HPRD:01286|
Locus tag  -
Gene type  protein-coding
Map location  2p13-p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0024 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTC39A0.910.61
NTNG10.900.55
RGS160.900.63
CHRNA30.880.49
PTPN30.860.36
FAM19A40.860.41
GRID2IP0.860.34
GALM0.850.57
SLC17A60.850.46
SUSD20.840.29
Top 10 negatively co-expressed genes
SLC26A4-0.25-0.18
TMOD1-0.24-0.13
GPR22-0.23-0.24
FAM81A-0.23-0.13
GPM6A-0.23-0.21
MEF2C-0.22-0.18
DPP4-0.22-0.18
IER5L-0.22-0.13
MPPED1-0.21-0.17
EMID1-0.21-0.23
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityNAS8423996 
GO:0005515protein bindingIPI10498867 |15799966 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001816cytokine productionIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045893positive regulation of transcription, DNA-dependentIEA-
GO:0045084positive regulation of interleukin-12 biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCNE1CCNEcyclin E1-HPRD9731206 
CDK2p33(CDK2)cyclin-dependent kinase 2Affinity Capture-WesternBioGRID9731206 
ELF1-E74-like factor 1 (ets domain transcription factor)Reconstituted ComplexBioGRID7862168 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID8413269 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD2155506 
MAP3K8COT | EST | ESTF | FLJ10486 | TPL2 | Tpl-2 | c-COTmitogen-activated protein kinase kinase kinase 8Affinity Capture-MSBioGRID14743216 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID8621542 
MTPNFLJ31098 | FLJ99857 | GCDP | V-1myotrophinAffinity Capture-Western
Reconstituted Complex		BioGRID11971907 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Affinity Capture-MSBioGRID14743216 
NFKB2LYT-10 | LYT10nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)-HPRD,BioGRID8413211 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaAffinity Capture-WesternBioGRID10706725 
NFKBIBIKBB | TRIP9nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaAffinity Capture-WesternBioGRID10706725 
NFKBIEIKBEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilonAffinity Capture-Western
Reconstituted Complex		BioGRID8415639 |9315679 
|10706725 
-HPRD8139561 |8415639 
|10706725 
NKRFITBA4 | NRFNFKB repressing factorReconstituted ComplexBioGRID10562553 
PAPOLAMGC5378 | PAPpoly(A) polymerase alphaAffinity Capture-MSBioGRID14743216 
PPP4CPP4 | PPH3 | PPXprotein phosphatase 4 (formerly X), catalytic subunit-HPRD,BioGRID9837938 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD7886940 |11967310 
Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID8139561 |11967310 
|14743216 
SP1-Sp1 transcription factor-HPRD,BioGRID7933095 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)Reconstituted ComplexBioGRID8670842 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1Affinity Capture-MSBioGRID14743216 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID8413269 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2Affinity Capture-MSBioGRID14743216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NFKAPPAB_ATYPICAL_PATHWAY 1715All SZGR genes in this pathway
PID_AR_TF_PATHWAY 5338All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN 13686All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
CHASSOT_SKIN_WOUND 109All SZGR genes in this pathway
GILMORE_CORE_NFKB_PATHWAY 1410All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_9 1913All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_B_LYMPHOCYTE_DN 3825All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
IIZUKA_LIVER_CANCER_EARLY_RECURRENCE 1110All SZGR genes in this pathway
HOFMANN_CELL_LYMPHOMA_UP 5035All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
XU_RESPONSE_TO_TRETINOIN_UP 1610All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
RAMASWAMY_METASTASIS_DN 6147All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH 6042All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_B 5336All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
ZHAN_EARLY_DIFFERENTIATION_GENES_DN 4229All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
TIAN_TNF_SIGNALING_VIA_NFKB 2821All SZGR genes in this pathway
PHONG_TNF_TARGETS_UP 6343All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.