Gene Page: RET

Summary
GeneID  5979
Symbol  RET
Synonyms  CDHF12|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1|RET51
Description  ret proto-oncogene
See related  HGNC:9967|MIM:164761|Ensembl:ENSG00000165731|HPRD:01266|
Locus tag  -
Gene type  protein-coding
Map location  10q11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KDM2A0.610.65
GON4L0.610.65
UBR40.610.65
CABLES20.600.65
AGPAT60.600.64
XXbac-B461K10.10.600.66
MAP3K30.600.65
TNRC6A0.600.64
TNRC6C0.600.65
DIDO10.600.64
Top 10 negatively co-expressed genes
AF347015.31-0.48-0.55
MT-CO2-0.46-0.53
IFI27-0.46-0.55
HIGD1B-0.45-0.56
B2M-0.45-0.53
AC021016.1-0.45-0.56
AF347015.27-0.45-0.52
AF347015.21-0.44-0.61
COPZ2-0.44-0.52
C5orf53-0.44-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityIEAneurite (GO term level: 8)-
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0004872receptor activityTAS7824936 
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005524ATP bindingNAS-
GO:0004713protein tyrosine kinase activityNAS-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0042551neuron maturationIEAneuron (GO term level: 10)-
GO:0048484enteric nervous system developmentIEAneuron (GO term level: 7)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0000165MAPKKK cascadeIEA-
GO:0001755neural crest cell migrationIEA-
GO:0001657ureteric bud developmentIEA-
GO:0001838embryonic epithelial tube formationIEA-
GO:0007156homophilic cell adhesionIEA-
GO:0006468protein amino acid phosphorylationNAS-
GO:0006468protein amino acid phosphorylationTAS7824936 
GO:0007165signal transductionTAS7824936 
GO:0007497posterior midgut developmentTAS8114939 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD12727845 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID9393871 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)-HPRD,BioGRID12087092 
DOK2p56DOK | p56dok-2docking protein 2, 56kDa-HPRD,BioGRID11470823 
DOK3DOKL | FLJ22570 | FLJ39939docking protein 3-HPRD11470823 
DOK4FLJ10488docking protein 4-HPRD,BioGRID11470823 
DOK5C20orf180 | MGC16926docking protein 5-HPRD,BioGRID11470823 
DOK6DOK5L | HsT3226 | MGC20785docking protein 6-HPRD,BioGRID15286081 
FRS2FRS2A | FRS2alpha | SNT | SNT-1 | SNT1fibroblast growth factor receptor substrate 2RET interacts with FRS2BIND11390647 
-HPRD,BioGRID11360177 
GAB1-GRB2-associated binding protein 1-HPRD11360177 
GDNFATF1 | ATF2 | HFB1-GDNFglial cell derived neurotrophic factor-HPRD8674117 |9482105 
GFRA1GDNFR | GDNFRA | GFR-ALPHA-1 | MGC23045 | RET1L | RETL1 | TRNR1GDNF family receptor alpha 1-HPRD9740802 |10829012 
Reconstituted ComplexBioGRID9192898 |10829012 
GOLGA5GOLIM5 | RFG5 | ret-IIgolgi autoantigen, golgin subfamily a, 5-HPRD2734021 |9915833 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD,BioGRID7665556 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD9393871 
Reconstituted ComplexBioGRID7665556 |8183561 
GRB7-growth factor receptor-bound protein 7-HPRD,BioGRID8631863 
NRTNNTNneurturin-HPRD,BioGRID9192898 
PDLIM7LMP1PDZ and LIM domain 7 (enigma)-HPRD,BioGRID12176011 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD10652352 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1RET9 phosphorylates PLC-gamma via its amino-terminal SH2 domain. This interaction was modelled on a demonstrated interaction between RET9 from human and PLC-gamma from cow.BIND9047383 
-HPRD,BioGRID8628282 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD,BioGRID11121408 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1RET9 phosphorylates Shc.BIND9047383 
-HPRD,BioGRID8183561 |9047384 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10070972 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID11536047 |12637586 
|15485908 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
NAKAMURA_CANCER_MICROENVIRONMENT_UP 2614All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_UP 4425All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_UP 7350All SZGR genes in this pathway
DOANE_BREAST_CANCER_ESR1_UP 11272All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
ELVIDGE_HYPOXIA_DN 14694All SZGR genes in this pathway
ELVIDGE_HYPOXIA_BY_DMOG_DN 5940All SZGR genes in this pathway
ELVIDGE_HIF2A_TARGETS_UP 65All SZGR genes in this pathway
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_UP 4122All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
LIEN_BREAST_CARCINOMA_METAPLASTIC_VS_DUCTAL_DN 11458All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN 6441All SZGR genes in this pathway
HASEGAWA_TUMORIGENESIS_BY_RET_C634R 117All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_UP 3728All SZGR genes in this pathway
STOSSI_RESPONSE_TO_ESTRADIOL 5035All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN 8049All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_UP 6644All SZGR genes in this pathway
FINETTI_BREAST_CANCERS_KINOME_BLUE 2116All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_UP 181112All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BRAIN_DN 8558All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
CONRAD_STEM_CELL 3927All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
VALK_AML_CLUSTER_16 2617All SZGR genes in this pathway
VALK_AML_WITH_11Q23_REARRANGED 2213All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
STEIN_ESR1_TARGETS 8555All SZGR genes in this pathway
STEIN_ESTROGEN_RESPONSE_NOT_VIA_ESRRA 1812All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_UP 8054All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/10711611167m8hsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-128159516021A,m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-15/16/195/424/497116211691A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-2186666721Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-2715961602m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-377111611231A,m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-503116311691Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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