Gene Page: RIT2

Summary
GeneID  6014
Symbol  RIT2
Synonyms  RIBA|RIN|ROC2
Description  Ras-like without CAAX 2
See related  HGNC:10017|MIM:609592|Ensembl:ENSG00000152214|HPRD:15253|
Locus tag  -
Gene type  protein-coding
Map location  18q12.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RNASEN0.920.92
WDR50.920.93
SFRS140.920.93
PRCC0.920.92
TACC20.920.94
UBAP2L0.910.92
LSM14B0.910.93
MSL10.910.92
SETD50.910.93
TOPBP10.910.92
Top 10 negatively co-expressed genes
AF347015.31-0.86-0.89
MT-CO2-0.85-0.88
AF347015.33-0.82-0.85
AF347015.27-0.82-0.86
MT-CYB-0.82-0.85
AF347015.8-0.81-0.87
HIGD1B-0.80-0.86
AF347015.21-0.79-0.89
AF347015.2-0.79-0.86
FXYD1-0.79-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003924GTPase activityNAS8824319 
GO:0005516calmodulin bindingTAS8824319 
GO:0005525GTP bindingTAS8824319 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8918462 
GO:0007165signal transductionTAS8918462 
GO:0007264small GTPase mediated signal transductionEXP10712923 
GO:0007264small GTPase mediated signal transductionNAS8824319 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005886plasma membraneTAS8824319 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD,BioGRID8824319 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4-HPRD10545207 
POU4F1BRN3A | FLJ13449 | Oct-T1 | RDC-1POU class 4 homeobox 1-HPRD,BioGRID12934100 
RAB5ARAB5RAB5A, member RAS oncogene familyBiochemical ActivityBioGRID11703925 
RALGDSFLJ20922 | RGF | RalGEFral guanine nucleotide dissociation stimulator-HPRD10545207 
RLFMGC142226 | ZN-15L | ZNF292Lrearranged L-myc fusion-HPRD,BioGRID10545207 
SOS1GF1 | GGF1 | GINGF | HGF | NS4son of sevenless homolog 1 (Drosophila)-HPRD,BioGRID12099688 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 1514All SZGR genes in this pathway
SILIGAN_BOUND_BY_EWS_FLT1_FUSION 4734All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_24HR_DN 3321All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_SHORT_TERM 3215All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_GAMMA_RADIATION 8159All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP 14175All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2062502571A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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