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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: RXRB

Summary

GeneID

6257

Symbol

RXRB

Synonyms

DAUDI6|H-2RIIBP|MGC1831|NR2B2|RCoR-1

Description

retinoid X receptor, beta

Locus tag

DADB-100D22.1

Gene type

protein-coding

Map location

6p21.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.033

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004886

retinoid-X receptor activity

TAS

1662118

GO:0003700

transcription factor activity

IEA

GO:0003700

transcription factor activity

NAS

1662118

GO:0003706

ligand-regulated transcription factor activity

IDA

7990953

GO:0003707

steroid hormone receptor activity

IEA

GO:0003713

transcription coactivator activity

TAS

1662118

GO:0005496

steroid binding

IEA

GO:0008270

zinc ion binding

IEA

GO:0046872

metal ion binding

IEA

GO:0043565

sequence-specific DNA binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IDA

7990953

GO:0005634

nucleus

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD,BioGRID	9627117
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD	7481822
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	TRAM-1 interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and mouse RXR-beta.	BIND	9346901
NCOA3		nuclear receptor coactivator 3	-	HPRD	9267036
NR0B2	FLJ17090 \| SHP \| SHP1	nuclear receptor subfamily 0, group B, member 2	-	HPRD	10594021
NR1H2	LXR-b \| LXRB \| NER \| NER-I \| RIP15 \| UNR	nuclear receptor subfamily 1, group H, member 2	-	HPRD,BioGRID	10187832
NR1I2	BXR \| ONR1 \| PAR \| PAR1 \| PAR2 \| PARq \| PRR \| PXR \| SAR \| SXR	nuclear receptor subfamily 1, group I, member 2	-	HPRD	9727070
NR2E3	ESCS \| MGC49976 \| PNR \| RNR \| RP37 \| rd7	nuclear receptor subfamily 2, group E, member 3	-	HPRD	10611353
NR4A2	HZF-3 \| NOT \| NURR1 \| RNR1 \| TINUR	nuclear receptor subfamily 4, group A, member 2	-	HPRD	7705655 \|7758108
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD	12403842 \|12549917
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	Reconstituted Complex	BioGRID	9626662
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	Two-hybrid	BioGRID	16189514
RARB	HAP \| NR1B2 \| RRB2	retinoic acid receptor, beta	-	HPRD	1331778
SPOP	TEF2	speckle-type POZ protein	Two-hybrid	BioGRID	16189514
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	-	HPRD	1331778
THRB	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	THR-beta interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between rat TR-beta and mouse RXR-beta.	BIND	9346901

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_PPAR_SIGNALING_PATHWAY	69	47	All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY	67	57	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_THYROID_CANCER	29	26	All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER	84	67	All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER	54	47	All SZGR genes in this pathway
PID_AR_TF_PATHWAY	53	38	All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY	26	24	All SZGR genes in this pathway
PID_RETINOIC_ACID_PATHWAY	30	23	All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY	46	35	All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	352	181	All SZGR genes in this pathway
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	49	36	All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP	567	375	All SZGR genes in this pathway
BOGNI_TREATMENT_RELATED_MYELOID_LEUKEMIA_DN	33	19	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP	1821	933	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	1142	669	All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	612	367	All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX	230	156	All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS	775	494	All SZGR genes in this pathway
URS_ADIPOCYTE_DIFFERENTIATION_UP	74	51	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	390	242	All SZGR genes in this pathway
MACLACHLAN_BRCA1_TARGETS_DN	16	12	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP	178	111	All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH	60	42	All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP	111	68	All SZGR genes in this pathway
LEE_LIVER_CANCER	49	29	All SZGR genes in this pathway
MATZUK_SPERMATOZOA	114	77	All SZGR genes in this pathway
MOOTHA_PGC	420	269	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
DUAN_PRDM5_TARGETS	79	52	All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3	824	528	All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES	462	273	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	666	673	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-144	667	673	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.