Gene Page: SHH

Summary
GeneID  6469
Symbol  SHH
Synonyms  HHG1|HLP3|HPE3|MCOPCB5|SMMCI|TPT|TPTPS
Description  sonic hedgehog homolog (Drosophila)
See related  HGNC:10848|MIM:600725|Ensembl:ENSG00000164690|HPRD:02838|
Locus tag  -
Gene type  protein-coding
Map location  7q36
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 8 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA14680.870.89
INPP5F0.870.89
PCYOX10.860.90
KIAA03170.860.90
MAPRE20.860.90
UBE2Z0.860.89
UGCG0.850.88
RTN40.850.88
RABGEF10.850.87
CLASP20.850.88
Top 10 negatively co-expressed genes
AF347015.31-0.69-0.71
MT-CO2-0.68-0.71
FXYD1-0.68-0.68
AF347015.21-0.67-0.71
AF347015.8-0.67-0.70
AF347015.33-0.67-0.67
AF347015.2-0.66-0.68
MT-CYB-0.65-0.67
AC021016.1-0.65-0.69
AF347015.27-0.65-0.67
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005113patched bindingIEA-
GO:0005515protein bindingISS-
GO:0008233peptidase activityIEA-
GO:0043237laminin-1 bindingISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceISSaxon (GO term level: 13)-
GO:0048663neuron fate commitmentISSneuron (GO term level: 9)-
GO:0021978telencephalon regionalizationIEABrain (GO term level: 10)-
GO:0060020Bergmann glial cell differentiationIEAastrocyte, Glial (GO term level: 6)-
GO:0030902hindbrain developmentISSBrain (GO term level: 8)-
GO:0030901midbrain developmentISSBrain (GO term level: 8)-
GO:0030900forebrain developmentISSBrain (GO term level: 8)-
GO:0014003oligodendrocyte developmentIEAaxon, oligodendrocyte, Glial (GO term level: 10)-
GO:0001755neural crest cell migrationISS-
GO:0001570vasculogenesisISS-
GO:0001569patterning of blood vesselsISS-
GO:0001658ureteric bud branchingISS-
GO:0001656metanephros developmentISS-
GO:0001708cell fate specificationISS-
GO:0002052positive regulation of neuroblast proliferationIEA-
GO:0002076osteoblast developmentIEA-
GO:0007267cell-cell signalingISS-
GO:0007228positive regulation of hh target transcription factor activityIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0009887organ morphogenesisISS-
GO:0007165signal transductionISS-
GO:0007507heart developmentISS-
GO:0007442hindgut morphogenesisIEA-
GO:0007435salivary gland morphogenesisISS-
GO:0007418ventral midline developmentTAS8896572 
GO:0007389pattern specification processISS-
GO:0008209androgen metabolic processISS-
GO:0030850prostate gland developmentISS-
GO:0031069hair follicle morphogenesisIEA-
GO:0016539intein-mediated protein splicingIEA-
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0051146striated muscle cell differentiationIEA-
GO:0021940positive regulation of granule cell precursor proliferationIEA-
GO:0021938smoothened signaling pathway involved in regulation of granule cell precursor cell proliferationIEA-
GO:0042733embryonic digit morphogenesisISS-
GO:0042130negative regulation of T cell proliferationIEA-
GO:0030539male genitalia developmentISS-
GO:0043010camera-type eye developmentIEA-
GO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic processIEA-
GO:0030162regulation of proteolysisISS-
GO:0030336negative regulation of cell migrationISS-
GO:0030324lung developmentISS-
GO:0021513spinal cord dorsal/ventral patterningIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0045596negative regulation of cell differentiationISS-
GO:0046639negative regulation of alpha-beta T cell differentiationIEA-
GO:0048568embryonic organ developmentIEA-
GO:0048589developmental growthIEA-
GO:0048598embryonic morphogenesisIEA-
GO:0045445myoblast differentiationIEA-
GO:0045449regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS-
GO:0009986cell surfaceISS-
GO:0005886plasma membraneIEA-
GO:0045121membrane raftISS-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
PTCH1BCNS | FLJ26746 | FLJ42602 | HPE7 | NBCCS | PTC | PTC1 | PTCH | PTCH11patched homolog 1 (Drosophila)-HPRD9811851 
PTCH2-patched homolog 2 (Drosophila)-HPRD9811851 
SHHHHG1 | HLP3 | HPE3 | MCOPCB5 | SMMCI | TPT | TPTPSsonic hedgehog homolog (Drosophila)-HPRD,BioGRID11395778 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_SHH_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_PTC1_PATHWAY 116All SZGR genes in this pathway
PID_HEDGEHOG_2PATHWAY 2217All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
PID_TAP63_PATHWAY 5440All SZGR genes in this pathway
PID_HNF3A_PATHWAY 4429All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP 11679All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
WEBER_METHYLATED_IN_COLON_CANCER 1813All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3 210148All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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