Gene Page: SLC6A11

Summary
GeneID  6538
Symbol  SLC6A11
Synonyms  GAT-3|GAT3
Description  solute carrier family 6 (neurotransmitter transporter, GABA), member 11
See related  HGNC:11044|MIM:607952|Ensembl:ENSG00000132164|HPRD:06406|
Locus tag  -
Gene type  protein-coding
Map location  3p25.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COPA0.860.86
ABCF20.860.86
CLCN60.850.85
UBE3B0.850.84
RANBP90.840.83
WAC0.840.85
UBE4B0.840.87
DEPDC50.840.86
COPG0.840.85
PDCD6IP0.840.85
Top 10 negatively co-expressed genes
AF347015.21-0.72-0.76
AF347015.31-0.69-0.70
MT-CO2-0.67-0.70
VAMP5-0.67-0.72
IFI27-0.67-0.71
METRN-0.66-0.70
S100A16-0.66-0.70
C1orf54-0.66-0.73
HIGD1B-0.66-0.70
FXYD1-0.65-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005332gamma-aminobutyric acid:sodium symporter activityIEAGABA, Neurotransmitter (GO term level: 11)-
GO:0005328neurotransmitter:sodium symporter activityIEANeurotransmitter (GO term level: 9)-
GO:0015293symporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006836neurotransmitter transportIEAneuron, Neurotransmitter (GO term level: 5)-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0005887integral to plasma membraneIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 241157All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_GLUCOSE_AND_OTHER_SUGARS_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS 8954All SZGR genes in this pathway
REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS 1712All SZGR genes in this pathway
REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS 2716All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED 536296All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_CLASSICAL 162122All SZGR genes in this pathway


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