Gene Page: BMP7

Summary
GeneID  655
Symbol  BMP7
Synonyms  OP-1
Description  bone morphogenetic protein 7
See related  HGNC:1074|MIM:112267|Ensembl:ENSG00000101144|HPRD:00212|
Locus tag  -
Gene type  protein-coding
Map location  20q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.368 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA12190.950.97
TAOK10.940.96
BRAF0.940.96
VCPIP10.940.96
ZYG11B0.940.96
RLIM0.930.96
DENND5B0.930.96
NUFIP20.930.96
SEL1L0.920.94
ZBTB440.920.94
Top 10 negatively co-expressed genes
FXYD1-0.66-0.75
HIGD1B-0.62-0.74
TLCD1-0.62-0.70
C19orf36-0.62-0.67
S100A16-0.61-0.70
CST3-0.60-0.70
AC021016.1-0.60-0.68
MT-CO2-0.60-0.72
SERPINB6-0.60-0.66
ENHO-0.60-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIEA-
GO:0005515protein bindingIPI12478285 |12667445 
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0001503ossificationIEA-
GO:0001707mesoderm formationIEA-
GO:0001837epithelial to mesenchymal transitionTAS14679171 
GO:0001822kidney developmentIEA-
GO:0009887organ morphogenesisIEA-
GO:0048468cell developmentIEA-
GO:0007435salivary gland morphogenesisIEA-
GO:0007389pattern specification processIEA-
GO:0042475odontogenesis of dentine-containing toothIEA-
GO:0030501positive regulation of bone mineralizationIDA18436533 
GO:0030509BMP signaling pathwayIEA-
GO:0051216cartilage developmentIEA-
GO:0048754branching morphogenesis of a tubeIEA-
GO:0040007growthIEA-
GO:0045941positive regulation of transcriptionIDA14517293 
GO:0045786negative regulation of cell cycleIDA11502704 
GO:0045669positive regulation of osteoblast differentiationIDA18436533 
GO:0048593camera-type eye morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR1ACTRI | ACVR1A | ACVRLK2 | ALK2 | FOP | SKR1 | TSRIactivin A receptor, type I-HPRD,BioGRID8006002 
ACVR2AACTRII | ACVR2activin A receptor, type IIA-HPRD,BioGRID9748228 
ACVR2BACTRIIB | ActR-IIB | MGC116908activin A receptor, type IIB-HPRD,BioGRID9748228 
BMP7OP-1bone morphogenetic protein 7Co-purificationBioGRID12478285 
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IAReconstituted ComplexBioGRID8006002 
-HPRD7791754 |8605097 
BMPR1BALK-6 | ALK6 | CDw293bone morphogenetic protein receptor, type IB-HPRD8605097 
Reconstituted ComplexBioGRID8006002 
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)-HPRD,BioGRID7791754 
ENGCD105 | END | FLJ41744 | HHT1 | ORW | ORW1endoglin-HPRD,BioGRID9872992 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3-HPRD7791754 
NOGSYM1 | SYNS1noggin-HPRD,BioGRID12478285 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1Phenotypic SuppressionBioGRID11438941 
SOSTDC1CDA019 | DKFZp564D206 | ECTODIN | USAG1sclerostin domain containing 1-HPRD,BioGRID14623234 |15020244 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
PID_BMP_PATHWAY 4231All SZGR genes in this pathway
PID_ALK2_PATHWAY 119All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_DN 11879All SZGR genes in this pathway
HUMMEL_BURKITTS_LYMPHOMA_UP 4327All SZGR genes in this pathway
PROVENZANI_METASTASIS_DN 13694All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3 7037All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
GOUYER_TATI_TARGETS_DN 1712All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_20Q12_Q13_AMPLICON 14976All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_UP 14293All SZGR genes in this pathway
BASSO_CD40_SIGNALING_DN 6844All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
NIELSEN_GIST_VS_SYNOVIAL_SARCOMA_UP 1912All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
LU_AGING_BRAIN_UP 262186All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P6 9144All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_DN 10563All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN 270181All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
CHENG_IMPRINTED_BY_ESTRADIOL 11068All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6 469239All SZGR genes in this pathway
ENGELMANN_CANCER_PROGENITORS_DN 7044All SZGR genes in this pathway
MCCABE_HOXC6_TARGETS_UP 108All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
GYORFFY_DOXORUBICIN_RESISTANCE 5634All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN 306191All SZGR genes in this pathway
NIELSEN_LEIOMYOSARCOMA_CNN1_DN 2018All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP 7547All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
PANGAS_TUMOR_SUPPRESSION_BY_SMAD1_AND_SMAD5_UP 13485All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
MALIK_REPRESSED_BY_ESTROGEN 1210All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-542-3p4384441Ahsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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