Gene Page: SPTAN1

Summary
GeneID  6709
Symbol  SPTAN1
Synonyms  (ALPHA)II-SPECTRIN|FLJ44613|NEAS
Description  spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
See related  HGNC:11273|MIM:182810|Ensembl:ENSG00000197694|HPRD:01684|
Locus tag  -
Gene type  protein-coding
Map location  9q33-q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.7272 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HNRNPUL10.970.94
RAF10.970.96
MTA20.970.94
DDX230.970.97
UBE2I0.970.95
SMARCB10.970.94
SF3B30.960.96
TRA2B0.960.95
WDR330.960.96
FUBP10.960.96
Top 10 negatively co-expressed genes
AF347015.31-0.78-0.92
AF347015.27-0.78-0.92
C5orf53-0.77-0.78
MT-CO2-0.77-0.92
HLA-F-0.77-0.79
AIFM3-0.76-0.80
AF347015.33-0.76-0.90
S100B-0.75-0.84
FXYD1-0.75-0.89
MT-CYB-0.75-0.90
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingTAS2307671 
GO:0005509calcium ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0005200structural constituent of cytoskeletonTAS2307671 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0051016barbed-end actin filament cappingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9624143 
GO:0005856cytoskeletonIEA-
GO:0005624membrane fractionTAS2307671 
GO:0005737cytoplasmIEA-
GO:0008091spectrinTAS2307671 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinaseReconstituted Complex
Two-hybrid		BioGRID9593709 
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD11971983 
ACTBPS1TP5BP1actin, beta-HPRD9209005 
ADD1ADDA | MGC3339 | MGC44427adducin 1 (alpha)-HPRD,BioGRID8663089 
ADD2ADDBadducin 2 (beta)-HPRD7642559 
ANK1ANK | SPH1 | SPH2ankyrin 1, erythrocytic-HPRD492324 |2141335 
|2970468 |2971657 
CAPN3CANP3 | CANPL3 | LGMD2 | LGMD2A | MGC10767 | MGC11121 | MGC14344 | MGC4403 | nCL-1 | p94calpain 3, (p94)-HPRD9642272 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDa-HPRD11069925 
DDX24-DEAD (Asp-Glu-Ala-Asp) box polypeptide 24Two-hybridBioGRID16169070 
DESCMD1I | CSM1 | CSM2 | FLJ12025 | FLJ39719 | FLJ41013 | FLJ41793desmin-HPRD,BioGRID2939097 
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1An unspecified isoform of DISC1 interacts with SPTAN1.BIND14623284 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Reconstituted ComplexBioGRID12044158 
-HPRD12049649 
EPB42MGC116735 | MGC116737 | PAerythrocyte membrane protein band 4.2-HPRD,BioGRID12049649 
ERCC4RAD1 | XPFexcision repair cross-complementing rodent repair deficiency, complementation group 4Affinity Capture-WesternBioGRID12571280 
EVLRNB6Enah/Vasp-likeAlphaII-spectrin interacts with EVL.BIND15656790 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group AAffinity Capture-Western
Co-purification		BioGRID10551855 |11401546 
|12571280 
FANCCFA3 | FAC | FACC | FLJ14675Fanconi anemia, complementation group CAffinity Capture-Western
Co-purification		BioGRID10551855 |11401546 
FANCGFAG | XRCC9Fanconi anemia, complementation group GCo-purificationBioGRID11401546 
GAP43B-50 | PP46growth associated protein 43-HPRD10521589 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Affinity Capture-Western
Far Western		BioGRID10576550 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1-HPRD9670010 |10862698 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD14743216 
NEFLCMT1F | CMT2E | FLJ53642 | NF-L | NF68 | NFLneurofilament, light polypeptide-HPRD,BioGRID1902666 |3121319 
PDE4DDPDE3 | HSPDE4D | PDE4DN2 | STRK1phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)PDE4D4 interacts with Fodrin. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Fodrin from an unspecified species.BIND10571082 
PIN4EPVH | MGC138486 | PAR14 | PAR17protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)Two-hybridBioGRID16169070 
PLEC1EBS1 | EBSO | HD1 | PCN | PLEC1b | PLTNplectin 1, intermediate filament binding protein 500kDa-HPRD,BioGRID3027087 
PRKCBMGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2protein kinase C, beta-HPRD8163551 
PTOV1ACID2 | DKFZp586I111 | MGC71475prostate tumor overexpressed 1Two-hybridBioGRID16169070 
PTP4A1DKFZp779M0721 | HH72 | PRL-1 | PRL1 | PTP(CAAX1) | PTPCAAX1protein tyrosine phosphatase type IVA, member 1-HPRD11971983 
SHANK1SPANK-1 | SSTRIP | synamonSH3 and multiple ankyrin repeat domains 1-HPRD,BioGRID11509555 
SHANK3KIAA1650 | PROSAP2 | PSAP2 | SPANK-2SH3 and multiple ankyrin repeat domains 3Two-hybridBioGRID11509555 
SLC9A2NHE2solute carrier family 9 (sodium/hydrogen exchanger), member 2-HPRD10579058 
SPTBHSpTB1spectrin, beta, erythrocytic-HPRD,BioGRID9890967 
SYN1SYN1a | SYN1b | SYNIsynapsin I-HPRD1905928 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TESDKFZp586B2022 | MGC1146 | TESS | TESS-2testis derived transcript (3 LIM domains)AlphaII-spectrin interacts with Tes.BIND15656790 
TSSC4-tumor suppressing subtransferable candidate 4Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
BIOCARTA_UCALPAIN_PATHWAY 1811All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 1311All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 2319All SZGR genes in this pathway
REACTOME_NEPHRIN_INTERACTIONS 2015All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_DN 4129All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_DN 12686All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_DN 162116All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN 329219All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN 14295All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
BARRIER_CANCER_RELAPSE_NORMAL_SAMPLE_DN 3119All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_UP 13493All SZGR genes in this pathway
WANG_HCP_PROSTATE_CANCER 11169All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_UP 5634All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_UP 6235All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
APRELIKOVA_BRCA1_TARGETS 4933All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8 8657All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP 8452All SZGR genes in this pathway
MALONEY_RESPONSE_TO_17AAG_UP 4126All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN 253192All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_UP 14094All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/10748541Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-29132138m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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