Gene Page: SPTBN1

Summary
GeneID  6711
Symbol  SPTBN1
Synonyms  ELF|SPTB2|betaSpII
Description  spectrin, beta, non-erythrocytic 1
See related  HGNC:11275|MIM:182790|Ensembl:ENSG00000115306|HPRD:01683|
Locus tag  -
Gene type  protein-coding
Map location  2p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.096 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LRRC4C0.780.87
CDH130.770.76
PRPS20.740.79
RP4-788L13.10.720.67
GPR1760.720.80
CACNA1I0.710.84
AC012652.10.710.82
PCDHA50.700.62
MARCH10.700.54
FAM19A10.700.73
Top 10 negatively co-expressed genes
PECI-0.39-0.38
IMPA2-0.37-0.45
RAB13-0.36-0.46
DECR1-0.35-0.29
ANP32B-0.34-0.46
C11orf67-0.33-0.26
ACAA2-0.32-0.29
AK2-0.32-0.32
AP002478.3-0.31-0.23
NSBP1-0.31-0.33
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003779actin bindingTAS1527002 
GO:0005516calmodulin bindingIEA-
GO:0005200structural constituent of cytoskeletonTAS1527002 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007184SMAD protein nuclear translocationIEA-
GO:0007182common-partner SMAD protein phosphorylationIEA-
GO:0051016barbed-end actin filament cappingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIEA-
GO:0005730nucleolusIDA9537418 
GO:0005737cytoplasmIDA9537418 
GO:0008091spectrinTAS1527002 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTR1AARP1 | CTRN1 | FLJ52695 | FLJ52800 | FLJ55002ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)-HPRD8991093 
CPNE1COPN1 | CPN1 | MGC1142copine I-HPRD12522145 
CPNE4COPN4 | CPN4 | MGC15604copine IV-HPRD12522145 
CTNNA1CAP102 | FLJ36832catenin (cadherin-associated protein), alpha 1, 102kDaReconstituted ComplexBioGRID11069925 
DCTN1DAP-150 | DP-150 | HMN7B | P135dynactin 1 (p150, glued homolog, Drosophila)Affinity Capture-WesternBioGRID8991093 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD12901833 
EPB41L34.1B | DAL-1 | DAL1 | FLJ37633 | KIAA0987erythrocyte membrane protein band 4.1-like 3Reconstituted ComplexBioGRID15116094 
EPB41L3 (DAL-1) interacts with an unspecified isoform of SPTBN1 (beta-II-spectrin).BIND15688033 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Far WesternBioGRID10576550 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon-HPRD14743216 
MAP3K3MAPKKK3 | MEKK3mitogen-activated protein kinase kinase kinase 3-HPRD14743216 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)-HPRD,BioGRID11535133 
RIPK3RIP3receptor-interacting serine-threonine kinase 3-HPRD14743216 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD12543979 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD12543979 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TGFBR_PATHWAY 5538All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_CELL_CELL_COMMUNICATION 12077All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 6449All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS 2319All SZGR genes in this pathway
REACTOME_NEPHRIN_INTERACTIONS 2015All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
CHOI_ATL_CHRONIC_VS_ACUTE_DN 1810All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
WANG_CLIM2_TARGETS_DN 186114All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_DN 232139All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_DN 4732All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_DN 9557All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP 6647All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_DN 14295All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_DN 10064All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN 4533All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_DN 2415All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
ROETH_TERT_TARGETS_DN 87All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_DN 246180All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
GEORGANTAS_HSC_MARKERS 7147All SZGR genes in this pathway
DAZARD_UV_RESPONSE_CLUSTER_G1 6741All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
CHENG_IMPRINTED_BY_ESTRADIOL 11068All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HINATA_NFKB_TARGETS_FIBROBLAST_UP 8460All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
CROONQUIST_STROMAL_STIMULATION_UP 6042All SZGR genes in this pathway
VALK_AML_CLUSTER_10 3322All SZGR genes in this pathway
VALK_AML_WITH_EVI1 2515All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_WITH_EPCAM_UP 5325All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_DN 1010All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_VINBLASTINE 1812All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_UP 14675All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p172178m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-1533213271Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d1711771Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-2199519571Ahsa-miR-219brainUGAUUGUCCAAACGCAAUUCU
miR-4102372431Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4483213271Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.