Gene Page: SRF

Summary
GeneID  6722
Symbol  SRF
Synonyms  MCM1
Description  serum response factor (c-fos serum response element-binding transcription factor)
See related  HGNC:11291|MIM:600589|Ensembl:ENSG00000112658|HPRD:02788|
Locus tag  -
Gene type  protein-coding
Map location  6p21.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIEA-
GO:0003702RNA polymerase II transcription factor activityTAS3203386 
GO:0008134transcription factor bindingIPI16054032 
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001829trophectodermal cell differentiationIDA17576768 
GO:0001947heart loopingIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007165signal transductionTAS3203386 
GO:0007507heart developmentIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA17576768 
GO:0045597positive regulation of cell differentiationIDA17576768 
GO:0046716muscle maintenanceIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005634nucleusTAS3203386 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 
GO:0005783endoplasmic reticulumIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASCC1ASC1p50 | CGI-18 | RP11-150D20.4activating signal cointegrator 1 complex subunit 1Reconstituted Complex
Two-hybrid
BioGRID12077347 
ASCC2ASC1p100activating signal cointegrator 1 complex subunit 2Reconstituted Complex
Two-hybrid
BioGRID12077347 
ASCC3ASC1p200 | DJ467N11.1 | HELIC1 | MGC26074 | RNAH | dJ121G13.4activating signal cointegrator 1 complex subunit 3Reconstituted Complex
Two-hybrid
BioGRID12077347 
ATF6ATF6Aactivating transcription factor 6-HPRD,BioGRID9271374 
BARX2MGC133368 | MGC133369BARX homeobox 2-HPRD11278942 
CD63LAMP-3 | ME491 | MLA1 | OMA81H | TSPAN30CD63 moleculeTwo-hybridBioGRID9271374 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD11500490 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9032301 |10318842 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-WesternBioGRID12622724 
CRIP2CRIP | CRP2 | ESP1cysteine-rich protein 2-HPRD12530967 
ELK1-ELK1, member of ETS oncogene family-HPRD,BioGRID9010223 
ELK4SAP1ELK4, ETS-domain protein (SRF accessory protein 1)-HPRD11406578 |11846562 
-HPRD,BioGRID11406578 
FHL1FHL1B | FLH1A | KYO-T | MGC111107 | SLIM1 | XMPMA | bA535K18.1four and a half LIM domains 1SRF interacts with FHL1. This interaction was modeled on a demonstrated interaction between human SRF and FHL1 from an unspecified species.BIND15610731 
FHL2AAG11 | DRAL | SLIM3four and a half LIM domains 2SRF interacts with FHL2.BIND15610731 
FHL3MGC19547 | MGC23614 | MGC8696 | SLIM2four and a half LIM domains 3SRF interacts with FHL3. This interaction was modeled on a demonstrated interaction between human SRF and FHL3 from an unspecified species.BIND15610731 
FHL5ACT | FLJ33049 | KIAA0776 | RP3-393D12.2 | dJ393D12.2four and a half LIM domains 5SRF interacts with ACT. This interaction was modeled on a demonstrated interaction between human SRF and ACT from an unspecified species.BIND15610731 
FLI1EWSR2 | SIC-1Friend leukemia virus integration 1-HPRD,BioGRID9010223 |10606656 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologSRF interacts with the c-fos promoter CArG box. This interaction was modeled on a demonstrated interaction between human SRF and c-fos promoter CArG box from an unspecified species.BIND15610731 
FOSL1FRA | FRA1 | fra-1FOS-like antigen 1SRF interacts with the region of the FRA-1 promoter containing the SRE and ATF sites.BIND15806162 
GATA4MGC126629GATA binding protein 4-HPRD,BioGRID11158291 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDa-HPRD,BioGRID7854423 |8106390 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD,BioGRID9334314 
HOPXCameo | HOP | LAGY | MGC20820 | NECC1 | OB1 | SMAP31 | TotoHOP homeobox-HPRD12297045 
MKL1BSAC | MAL | MRTF-Amegakaryoblastic leukemia (translocation) 1-HPRD,BioGRID12397177|14565952 
-HPRD14565952 
MKL2DKFZp686J1745 | FLJ31823 | FLJ45623 | MRTF-B | NPD001MKL/myocardin-like 2-HPRD,BioGRID12397177 |14565952 
MYOCDMYCDmyocardin-HPRD,BioGRID11439182 |12397177 
|15014501 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD8617811 
MYOGMYF4 | MYOGENIN | bHLHc3myogenin (myogenic factor 4)-HPRD,BioGRID8617811 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD9786846 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Reconstituted ComplexBioGRID10847592 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD,BioGRID10777532 
NFYACBF-A | CBF-B | FLJ11236 | HAP2 | NF-YAnuclear transcription factor Y, alphaNF-YA interacts with SRF. This interaction was modeled on a demonstrated interaction between NF-YA from an unspecified species and SRF from human.BIND10571058 
Reconstituted Complex
Two-hybrid
BioGRID10571058 
NKX2-3CSX3 | NK2.3 | NKX2.3 | NKX2C | NKX4-3NK2 transcription factor related, locus 3 (Drosophila)-HPRD11457859 
NKX2-5CHNG5 | CSX | CSX1 | NKX2.5 | NKX2E | NKX4-1NK2 transcription factor related, locus 5 (Drosophila)-HPRD8887666 
NKX3-1BAPX2 | NKX3 | NKX3.1 | NKX3ANK3 homeobox 1-HPRD,BioGRID10993896 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID12622724 
PRRX1PHOX1 | PMX1 | PRX1paired related homeobox 1-HPRD9334314 
PYCARDASC | CARD5 | MGC10332 | TMS | TMS-1 | TMS1PYD and CARD domain containing-HPRD10847592 
RARGNR1B3 | RARCretinoic acid receptor, gammaReconstituted ComplexBioGRID11641790 
RELC-Relv-rel reticuloendotheliosis viral oncogene homolog (avian)Reconstituted ComplexBioGRID8670842 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Reconstituted ComplexBioGRID8670842 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD11641790 
RXRGNR2B3 | RXRCretinoid X receptor, gamma-HPRD,BioGRID11641790 
SP1-Sp1 transcription factorReconstituted ComplexBioGRID10082523 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID9786846 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD11406578 
SSRP1FACT | FACT80 | T160structure specific recognition protein 1-HPRD,BioGRID10336466 
TEAD1AA | REF1 | TCF13 | TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)-HPRD,BioGRID11136726 |12061776 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
BIOCARTA_EGF_PATHWAY 3125All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_IGF1_PATHWAY 2116All SZGR genes in this pathway
BIOCARTA_IL6_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INSULIN_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_PDGF_PATHWAY 3225All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
ST_P38_MAPK_PATHWAY 3728All SZGR genes in this pathway
ST_GA13_PATHWAY 3732All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_P38_MK2_PATHWAY 2119All SZGR genes in this pathway
PID_PDGFRA_PATHWAY 2218All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
YEMELYANOV_GR_TARGETS_DN 108All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_DN 185115All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_DN 165107All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_DN 180110All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN 181107All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP 479299All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BENPORATH_ES_CORE_NINE_CORRELATED 10068All SZGR genes in this pathway
COLLIS_PRKDC_SUBSTRATES 2015All SZGR genes in this pathway
MAGRANGEAS_MULTIPLE_MYELOMA_IGG_VS_IGA_UP 2212All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_TBH_AND_H2O2 3624All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D5 3926All SZGR genes in this pathway
ZHU_CMV_ALL_UP 12089All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN 312203All SZGR genes in this pathway
ZHU_CMV_24_HR_UP 9365All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_PROGRESSION_DN 2116All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
PARK_APL_PATHOGENESIS_DN 5035All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_DN 7247All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M 216124All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101131513211Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-1221451511Ahsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-125/351470476m8hsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-142-5p13601366m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-144131513211Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-15020362042m8hsa-miR-150UCUCCCAACCCUUGUACCAGUG
miR-18669751Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/42913841390m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-22131013161Ahsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-28531537m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-37720212027m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-485-5p398404m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
miR-48614011407m8hsa-miR-486UCCUGUACUGAGCUGCCCCGAG
miR-7659665m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-91531591Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.