Gene Page: STK11

Summary
GeneID  6794
Symbol  STK11
Synonyms  LKB1|PJS
Description  serine/threonine kinase 11
See related  HGNC:11389|MIM:602216|HPRD:03740|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0208 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
COX5B0.850.71
TMEM2190.850.74
COX4I10.830.68
NENF0.830.69
MSRB20.820.72
HINT20.810.68
SEPW10.810.68
C19orf700.810.67
C12orf620.810.70
NDUFB90.810.64
Top 10 negatively co-expressed genes
BAT2D1-0.61-0.58
MACF1-0.55-0.53
BDP1-0.55-0.54
ZC3H13-0.54-0.53
BOD1L-0.54-0.53
UPF2-0.53-0.50
CHD2-0.53-0.53
RAPH1-0.52-0.51
MDN1-0.52-0.50
GIGYF2-0.52-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA12805220 
GO:0005515protein bindingIPI17216128 
GO:0005524ATP bindingIDA12805220 
GO:0004674protein serine/threonine kinase activityIDA12805220 
GO:0016740transferase activityIEA-
GO:0030145manganese ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIDA12805220 
GO:0007049cell cycleIEA-
GO:0007050cell cycle arrestIDA12805220 |17216128 
GO:0008285negative regulation of cell proliferationIMP17216128 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12805220 
GO:0005737cytoplasmIDA12805220 |17216128 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39Affinity Capture-WesternBioGRID15561763 
-HPRD14676191 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)-HPRD,BioGRID12489981 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1Affinity Capture-Western
Reconstituted Complex		BioGRID12489981 
MARK2EMK1 | MGC99619 | PAR-1 | Par1bMAP/microtubule affinity-regulating kinase 2-HPRD14976552 
MARK4FLJ90097 | KIAA1860 | MARKL1 | Nbla00650MAP/microtubule affinity-regulating kinase 4LKB1 phosphorylates MARK4.BIND14676191 
PRKAA2AMPK | AMPK2 | PRKAAprotein kinase, AMP-activated, alpha 2 catalytic subunitLKB1 interacts with AMPK-alpha.BIND14985505 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID11445556 
STK11LKB1 | PJSserine/threonine kinase 11LKB1 autophosphorylates itself.BIND14676191 
STK11IPKIAA1898 | LIP1 | LKB1IP | STK11IP1serine/threonine kinase 11 interacting protein-HPRD,BioGRID11741830 
STRADAFLJ90524 | LYK5 | NY-BR-96 | PMSE | STRAD | StlkSTE20-related kinase adaptor alpha-HPRD,BioGRID12805220 
STRADBALS2CR2 | CALS-21 | ILPIP | ILPIPA | MGC102916 | PAPK | PRO1038STE20-related kinase adaptor betaLKB1 phosphorylates PAPK.BIND14676191 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2-HPRD12595760 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11430832 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE 1916All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 1513All SZGR genes in this pathway
REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 1815All SZGR genes in this pathway
REACTOME_PKB_MEDIATED_EVENTS 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
BIDUS_METASTASIS_DN 16193All SZGR genes in this pathway
CORRADETTI_MTOR_PATHWAY_REGULATORS_DN 65All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA 4331All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC 10874All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_FREQUENTLY 1210All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_TRANS 185114All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN 354216All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_RECURRENTLY 65All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_UP 4833All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_COMPLETE 227151All SZGR genes in this pathway


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