Gene Page: HNF1A

Summary
GeneID  6927
Symbol  HNF1A
Synonyms  HNF1|LFB1|MODY3|TCF1
Description  HNF1 homeobox A
See related  HGNC:11621|MIM:142410|Ensembl:ENSG00000135100|HPRD:00800|
Locus tag  -
Gene type  protein-coding
Map location  12q22-qter|12q24.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0538 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA11980910 
GO:0003702RNA polymerase II transcription factor activityIDA10330009 
GO:0005515protein bindingIPI11980910 
GO:0016563transcription activator activityIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0010551regulation of specific transcription from RNA polymerase II promoterIDA10330009 
GO:0042593glucose homeostasisIMP15277395 
GO:0045893positive regulation of transcription, DNA-dependentIDA11980910 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0043234protein complexIDA11980910 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AESAES-1 | AES-2 | ESP1 | GRG | GRG5 | TLE5amino-terminal enhancer of splitTwo-hybridBioGRID11266540 
ALBDKFZp779N1935 | PRO0883 | PRO0903 | PRO1341albumin-HPRD2460858 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)Affinity Capture-MSBioGRID17353931 
CDX2CDX-3 | CDX3caudal type homeobox 2-HPRD,BioGRID10677375 
CEBPAC/EBP-alpha | CEBPCCAAT/enhancer binding protein (C/EBP), alpha-HPRD8288579 
CREBBPCBP | KAT3A | RSTSCREB binding proteinCBP interacts with the HNF-1 gene.BIND15616580 
-HPRD,BioGRID10777539 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD11266540 |12107263 
ELP3FLJ10422 | KAT9elongation protein 3 homolog (S. cerevisiae)Elp3 interacts with the HNF-1 gene.BIND15616580 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID11978637 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD,BioGRID11134330 
GATA5bB379O24.1GATA binding protein 5-HPRD12011060 |14715527 
H3F3AH3.3A | H3F3 | MGC87782 | MGC87783H3 histone, family 3AH3F3A (Histone 3) interacts with the TCF1 (HNF-1) gene.BIND15616580 
HIST4H4H4/p | MGC24116histone cluster 4, H4HIST4H4 (Histone 4) interacts with the TCF1 (HNF-1) gene.BIND15616580 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox A-HPRD,BioGRID2044952 
HNF1BFJHN | HNF1beta | HNF2 | HPC11 | LF-B3 | LFB3 | MODY5 | TCF2 | VHNF1HNF1 homeobox BReconstituted ComplexBioGRID2044952 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alpha-HPRD9792724 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD,BioGRID10777539 
PCBD1DCOH | PCBD | PCD | PHSpterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha-HPRD,BioGRID9092652 
PCBD2DCOH2 | DCOHM | PHS2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2Affinity Capture-MSBioGRID17353931 
RAC3-ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)-HPRD,BioGRID10777539 
RHPN2RhoBP | p76RBErhophilin, Rho GTPase binding protein 2Affinity Capture-MSBioGRID17353931 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Brg-1 interacts with the HNF-1 gene.BIND15616580 
SMARCA5ISWI | SNF2H | WCRF135 | hISWI | hSNF2HSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5SNF2H interacts with the HNF-1 gene.BIND15616580 
SNRPA1-small nuclear ribonucleoprotein polypeptide A'Affinity Capture-MSBioGRID17353931 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID10777539 
SSRP1FACT | FACT80 | T160structure specific recognition protein 1FACT interacts with the HNF-1 gene.BIND15616580 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID11134330 
TLE1ESG | ESG1 | GRG1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)-HPRD,BioGRID10209158 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 2519All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_GH_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_PS1_PATHWAY 1414All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_HNF3B_PATHWAY 4537All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT 3023All SZGR genes in this pathway
REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS 2015All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MA_MYELOID_DIFFERENTIATION_DN 4430All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
NIKOLSKY_OVERCONNECTED_IN_BREAST_CANCER 2219All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_UP 170107All SZGR genes in this pathway
MATZUK_IMPLANTATION_AND_UTERINE 2215All SZGR genes in this pathway
ZHOU_PANCREATIC_BETA_CELL 119All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
GU_PDEF_TARGETS_DN 3920All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway


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