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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: ACTC1

Summary

GeneID

Symbol

ACTC1

Synonyms

ACTC|CMD1R|CMH11

Description

actin, alpha, cardiac muscle 1

Locus tag

Gene type

protein-coding

Map location

15q11-q14

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.0172

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000166

nucleotide binding

IEA

GO:0005515

protein binding

IEA

GO:0005524

ATP binding

IDA

16611632

GO:0005198

structural molecule activity

IEA

GO:0017022

myosin binding

IPI

16611632

GO:0016887

ATPase activity

IDA

16611632 |17765196

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0055008

cardiac muscle morphogenesis

ISS

GO:0055003

cardiac myofibril assembly

ISS

GO:0030240

muscle thin filament assembly

ISS

GO:0030048

actin filament-based movement

IDA

16611632

GO:0006915

apoptosis

ISS

GO:0031032

actomyosin structure organization

ISS

GO:0060047

heart contraction

IMP

9563954 |17611253 |17947298

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005856

cytoskeleton

IEA

GO:0005737

cytoplasm

IEA

GO:0031674

I band

ISS

GO:0042643

actomyosin, actin part

IDA

16611632

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABLIM3	HMFN1661	actin binding LIM protein family, member 3	-	HPRD,BioGRID	15337165
ABRA	STARS	actin-binding Rho activating protein	-	HPRD	11983702
ACTB	PS1TP5BP1	actin, beta	-	HPRD	8913639
ACTN4	ACTININ-4 \| DKFZp686K23158 \| FSGS \| FSGS1	actinin, alpha 4	-	HPRD	12042308
ACTR2	ARP2	ARP2 actin-related protein 2 homolog (yeast)	-	HPRD,BioGRID	12019562
AFAP1	AFAP \| AFAP-110 \| FLJ56849	actin filament associated protein 1	Reconstituted Complex	BioGRID	12134071
ANG	ALS9 \| HEL168 \| MGC22466 \| MGC71966 \| RNASE4 \| RNASE5	angiogenin, ribonuclease, RNase A family, 5	-	HPRD	8127865
CAPN1	CANP \| CANP1 \| CANPL1 \| muCANP \| muCL	calpain 1, (mu/I) large subunit	CAPN1 interacts with ACTC.	BIND	12358155
CFL1	CFL	cofilin 1 (non-muscle)	-	HPRD	12207032
DMD	BMD \| CMD3B \| DXS142 \| DXS164 \| DXS206 \| DXS230 \| DXS239 \| DXS268 \| DXS269 \| DXS270 \| DXS272	dystrophin	-	HPRD	11997265
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	-	HPRD	14760703
EPB49	DMT \| FLJ78462 \| FLJ98848	erythrocyte membrane protein band 4.9 (dematin)	-	HPRD	12011427
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	-	HPRD	12271120
FSCN1	FLJ38511 \| SNL \| p55	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	-	HPRD	12139639
GC	DBP \| DBP/GC \| VDBG \| VDBP	group-specific component (vitamin D binding protein)	-	HPRD,BioGRID	12452439 \|12554937
KLHL17	RP11-54O7.6	kelch-like 17 (Drosophila)	-	HPRD	12063253
KPTN	2E4	kaptin (actin binding protein)	-	HPRD	12019562
LASP1	Lasp-1 \| MLN50	LIM and SH3 protein 1	-	HPRD	9848085
MIB2	FLJ20648 \| FLJ39787 \| ZZANK1 \| ZZZ5	mindbomb homolog 2 (Drosophila)	-	HPRD	14507647
MYLK	DKFZp686I10125 \| FLJ12216 \| KRP \| MLCK \| MLCK1 \| MLCK108 \| MLCK210 \| MSTP083 \| MYLK1 \| smMLCK	myosin light chain kinase	-	HPRD	12110694
PLEC1	EBS1 \| EBSO \| HD1 \| PCN \| PLEC1b \| PLTN	plectin 1, intermediate filament binding protein 500kDa	-	HPRD	12136158
PPP1R9B	FLJ30345 \| PPP1R6 \| PPP1R9 \| SPINO \| Spn	protein phosphatase 1, regulatory (inhibitor) subunit 9B	-	HPRD	12270929\|12417592
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD	11968018
SCIN	KIAA1905	scinderin	-	HPRD	12438125
SYNE1	8B \| CPG2 \| DKFZp781J13156 \| FLJ30878 \| FLJ41140 \| KIAA0796 \| KIAA1262 \| KIAA1756 \| MYNE1 \| SCAR8	spectrin repeat containing, nuclear envelope 1	-	HPRD	12408964
SYNE2	DKFZp434H2235 \| DKFZp686E01115 \| DKFZp686H1931 \| FLJ11014 \| FLJ43727 \| FLJ45710 \| FLJ46790 \| KIAA1011 \| NUA \| NUANCE \| Nesprin-2 \| SYNE-2	spectrin repeat containing, nuclear envelope 2	-	HPRD,BioGRID	12118075 \|12408964
TNNI3K	CARK \| MGC142099 \| MGC33828	TNNI3 interacting kinase	-	HPRD,BioGRID	12721663
TWF1	A6 \| MGC23788 \| MGC41876 \| PTK9	twinfilin, actin-binding protein, homolog 1 (Drosophila)	-	HPRD	12207032
WAS	IMD2 \| THC \| WASP	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	-	HPRD	12029088
WIPF1	MGC111041 \| PRPL-2 \| WASPIP \| WIP	WAS/WASL interacting protein family, member 1	-	HPRD	12029088

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CARDIAC_MUSCLE_CONTRACTION	80	51	All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM	85	65	All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY	92	68	All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN	68	49	All SZGR genes in this pathway
PAPASPYRIDONOS_UNSTABLE_ATEROSCLEROTIC_PLAQUE_DN	43	29	All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN	48	34	All SZGR genes in this pathway
RICKMAN_HEAD_AND_NECK_CANCER_F	54	32	All SZGR genes in this pathway
BENPORATH_ES_1	379	235	All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA	164	118	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP	398	262	All SZGR genes in this pathway
BHATTACHARYA_EMBRYONIC_STEM_CELL	89	60	All SZGR genes in this pathway
GUO_HEX_TARGETS_DN	65	36	All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP	214	133	All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_DN	80	49	All SZGR genes in this pathway
APRELIKOVA_BRCA1_TARGETS	49	33	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_UP	43	33	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
TSENG_IRS1_TARGETS_DN	135	88	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_UP	25	13	All SZGR genes in this pathway
KUNINGER_IGF1_VS_PDGFB_TARGETS_UP	82	51	All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL	311	205	All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN	32	25	All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_DN	67	46	All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM	66	47	All SZGR genes in this pathway
LEIN_OLIGODENDROCYTE_MARKERS	74	53	All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN	543	317	All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP	602	364	All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN	591	366	All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN	353	226	All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_E2	28	21	All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP	425	298	All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN	435	289	All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_UP	89	61	All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_16	79	47	All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_DN	315	215	All SZGR genes in this pathway
WANG_NFKB_TARGETS	25	15	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	148	154	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-299-5p	157	163	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-30-5p	105	112	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-495	102	108	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.