Gene Page: TGFA

Summary
GeneID  7039
Symbol  TGFA
Synonyms  TFGA
Description  transforming growth factor, alpha
See related  HGNC:11765|MIM:190170|Ensembl:ENSG00000163235|HPRD:07522|
Locus tag  -
Gene type  protein-coding
Map location  2p13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0833 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CRYBG30.880.88
SASH10.880.87
SHROOM40.870.85
SSFA20.870.86
DOCK10.860.82
KIAA04940.850.85
ARHGEF100.850.85
TJP20.850.78
MTMR100.850.76
KIF13B0.850.78
Top 10 negatively co-expressed genes
RPL35-0.54-0.64
PFDN5-0.53-0.59
RPL31-0.53-0.64
RPL27-0.53-0.64
RPL36-0.51-0.62
FAM128A-0.50-0.51
TIMM8B-0.50-0.59
RPS21-0.49-0.63
ZNF32-0.49-0.52
RPS7-0.49-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS2103501 |10918572 
GO:0001948glycoprotein bindingIEA-
GO:0004708MAP kinase kinase activityIDA11278323 
GO:0005155epidermal growth factor receptor activating ligand activityIDA11278323 
GO:0008083growth factor activityIDA11278323 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityIDA11278323 
GO:0001525angiogenesisIEA-
GO:0008283cell proliferationTAS10861448 
GO:0045741positive regulation of epidermal growth factor receptor activityIDA11278323 
GO:0045840positive regulation of mitosisIDA11278323 
GO:0050679positive regulation of epithelial cell proliferationIDA11278323 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneNAS10918572 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID12297049 
FGF5HBGF-5 | Smag-82fibroblast growth factor 5-HPRD1658709 
GORASP1FLJ23443 | GOLPH5 | GRASP65 | MGC118894 | MGC118897 | P65golgi reassembly stacking protein 1, 65kDaReconstituted Complex
Two-hybrid		BioGRID11739402 
GORASP2DKFZp434D156 | FLJ13139 | GOLPH6 | GRASP55 | GRS2 | p59golgi reassembly stacking protein 2, 55kDaReconstituted Complex
Two-hybrid		BioGRID11739402 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)Pro-TGF-alpha interacts with ST-1. This interaction was modelled on a demonstrated interaction between human Pro-TGF-alpha and rat ST-1.BIND11152476 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
KEGG_PANCREATIC_CANCER 7056All SZGR genes in this pathway
KEGG_GLIOMA 6556All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_NON_SMALL_CELL_LUNG_CANCER 5447All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_ERBB_NETWORK_PATHWAY 1513All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_6HR_DN 1813All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN 198110All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
HOOI_ST7_TARGETS_UP 9457All SZGR genes in this pathway
CASORELLI_APL_SECONDARY_VS_DE_NOVO_UP 3925All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_UP 306188All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
DARWICHE_SKIN_TUMOR_PROMOTER_UP 14296All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_LOW_UP 162104All SZGR genes in this pathway
DARWICHE_PAPILLOMA_RISK_HIGH_UP 147101All SZGR genes in this pathway
DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP 146104All SZGR genes in this pathway
BREUHAHN_GROWTH_FACTOR_SIGNALING_IN_LIVER_CANCER 2219All SZGR genes in this pathway
AGARWAL_AKT_PATHWAY_TARGETS 109All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_DN 3025All SZGR genes in this pathway
BORLAK_LIVER_CANCER_EGF_UP 5741All SZGR genes in this pathway
LI_WILMS_TUMOR_VS_FETAL_KIDNEY_2_DN 5142All SZGR genes in this pathway
HE_PTEN_TARGETS_DN 76All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA 6947All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_MCF10A 2013All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_240_MCF10A 5736All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
ONDER_CDH1_TARGETS_1_DN 169102All SZGR genes in this pathway
ONDER_CDH1_TARGETS_3_DN 5932All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
ZUCCHI_METASTASIS_UP 4324All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
STONER_ESOPHAGEAL_CARCINOGENESIS_UP 3925All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_UP 11484All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
HARRIS_HYPOXIA 8164All SZGR genes in this pathway
LEONARD_HYPOXIA 4735All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_UP 425253All SZGR genes in this pathway
WINTER_HYPOXIA_METAGENE 242168All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN 13892All SZGR genes in this pathway
HELLEBREKERS_SILENCED_DURING_TUMOR_ANGIOGENESIS 8056All SZGR genes in this pathway
MIZUKAMI_HYPOXIA_UP 1212All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
KOBAYASHI_EGFR_SIGNALING_24HR_DN 251151All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS 3625All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
AZARE_NEOPLASTIC_TRANSFORMATION_BY_STAT3_UP 12170All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_UP 6849All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_UP 271165All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
WACKER_HYPOXIA_TARGETS_OF_VHL 1311All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
PEDERSEN_TARGETS_OF_611CTF_ISOFORM_OF_ERBB2 7645All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-148/152334533521A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-2334203426m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323341934261A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-326511m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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