Gene Page: TIAM1

Summary
GeneID  7074
Symbol  TIAM1
Synonyms  FLJ36302
Description  T-cell lymphoma invasion and metastasis 1
See related  HGNC:11805|MIM:600687|Ensembl:ENSG00000156299|HPRD:02820|
Locus tag  -
Gene type  protein-coding
Map location  21q22.1|21q22.11
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0476 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA-
GO:0005089Rho guanyl-nucleotide exchange factor activityTAS10835422 
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005057receptor signaling protein activityIEA-
GO:0005543phospholipid bindingIEA-
GO:0005515protein bindingIEA-
GO:0046875ephrin receptor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0050772positive regulation of axonogenesisIEAaxon, neurogenesis (GO term level: 14)-
GO:0007165signal transductionIEA-
GO:0048013ephrin receptor signaling pathwayIEA-
GO:0007264small GTPase mediated signal transductionIEA-
GO:0035023regulation of Rho protein signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ANK1ANK | SPH1 | SPH2ankyrin 1, erythrocytic-HPRD,BioGRID10893266 
ANK3ANKYRIN-G | FLJ45464ankyrin 3, node of Ranvier (ankyrin G)Affinity Capture-WesternBioGRID10893266 
CAMK2GCAMK | CAMK-II | CAMKG | FLJ16043 | MGC26678calcium/calmodulin-dependent protein kinase II gamma-HPRD10212259 
CD44CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1CD44 molecule (Indian blood group)-HPRD,BioGRID10636882 
GRIN1NMDA1 | NMDAR1 | NR1glutamate receptor, ionotropic, N-methyl D-aspartate 1Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species.BIND15721239 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD,BioGRID12134164 
MAPK8IP1IB1 | JIP-1 | JIP1 | PRKM8IPmitogen-activated protein kinase 8 interacting protein 1-HPRD,BioGRID12024021 
MAPK8IP2IB2 | JIP2 | PRKM8IPLmitogen-activated protein kinase 8 interacting protein 2Affinity Capture-WesternBioGRID12024021 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID12446731 
NME1AWD | GAAD | NB | NBS | NDPK-A | NDPKA | NM23 | NM23-H1non-metastatic cells 1, protein (NM23A) expressed in-HPRD,BioGRID11274357 
PPP1R9BFLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spnprotein phosphatase 1, regulatory (inhibitor) subunit 9B-HPRD,BioGRID12531897 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alpha-HPRD,BioGRID10212259 
PRKCBMGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2protein kinase C, betaBiochemical ActivityBioGRID10212259 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID10212259 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilon-HPRD,BioGRID10212259 
PRKCGMGC57564 | PKC-gamma | PKCC | PKCG | SCA14protein kinase C, gamma-HPRD,BioGRID10212259 
PRKCZPKC-ZETA | PKC2protein kinase C, zetaBiochemical ActivityBioGRID10212259 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)The GTPase Rac1 specifically interacts with Dbl-homology domain of the nucleotide exchange factor TIAM1. This interaction is modelled on a demonstrated interaction between mouse TIAM1 and human Rac1.BIND11130063 
-HPRD,BioGRID11130063 |11595749 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD12810717 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_ARF6_DOWNSTREAM_PATHWAY 1514All SZGR genes in this pathway
PID_AJDISS_2PATHWAY 4838All SZGR genes in this pathway
PID_ECADHERIN_NASCENT_AJ_PATHWAY 3933All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_RAC1_REG_PATHWAY 3825All SZGR genes in this pathway
PID_EPHRINB_REV_PATHWAY 3025All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY 1916All SZGR genes in this pathway
REACTOME_SIGNALING_BY_RHO_GTPASES 11381All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 4333All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_DN 241146All SZGR genes in this pathway
WANG_LMO4_TARGETS_UP 372227All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_ADVANCED_VS_EARLY_UP 175120All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP 157104All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
KIM_WT1_TARGETS_UP 214155All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN 199124All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_DN 6743All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP 15093All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN 10166All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
SCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN 4533All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 160110All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
BECKER_TAMOXIFEN_RESISTANCE_DN 5237All SZGR genes in this pathway
SANSOM_APC_TARGETS_UP 12684All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_UP 8767All SZGR genes in this pathway
MARTINEZ_RESPONSE_TO_TRABECTEDIN 5032All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_8HR 3931All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C5 4636All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T4 9469All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P4 10062All SZGR genes in this pathway
SANSOM_APC_TARGETS 212121All SZGR genes in this pathway
SANSOM_WNT_PATHWAY_REQUIRE_MYC 5843All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
JI_CARCINOGENESIS_BY_KRAS_AND_STK11_UP 127All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_DN 258160All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
POS_HISTAMINE_RESPONSE_NETWORK 3222All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
BOHN_PRIMARY_IMMUNODEFICIENCY_SYNDROM_UP 4730All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
ZHAN_V1_LATE_DIFFERENTIATION_GENES_UP 3225All SZGR genes in this pathway
MARSON_FOXP3_TARGETS_UP 6643All SZGR genes in this pathway
STEIN_ESR1_TARGETS 8555All SZGR genes in this pathway
STEIN_ESTROGEN_RESPONSE_NOT_VIA_ESRRA 1812All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_UP 229149All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_5_DN 5031All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP 211131All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_UP 281183All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D 280158All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
KATSANOU_ELAVL1_TARGETS_DN 14888All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE 15186All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10116311701A,m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-141/200a7457521A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-5p144814551A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d12351241m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-18317951801m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-2118611867m8hsa-miR-21brainUAGCUUAUCAGACUGAUGUUGA
hsa-miR-590GAGCUUAUUCAUAAAAGUGCAG
miR-2917801786m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-320162516311Ahsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-32926321Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-376c18301836m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-410184618521Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-93.hd/291-3p/294/295/302/372/373/52012341240m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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