Gene Page: TOP2B

Summary
GeneID  7155
Symbol  TOP2B
Synonyms  TOPIIB|top2beta
Description  topoisomerase (DNA) II beta 180kDa
See related  HGNC:11990|MIM:126431|Ensembl:ENSG00000077097|HPRD:00537|
Locus tag  -
Gene type  protein-coding
Map location  3p24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003682chromatin bindingIDA9049244 
GO:0003918DNA topoisomerase (ATP-hydrolyzing) activityIEA-
GO:0005080protein kinase C bindingIPI16611985 
GO:0005524ATP bindingIEA-
GO:0008022protein C-terminus bindingIPI10666337 
GO:0042826histone deacetylase bindingIPI11062478 |11136718 
GO:0046982protein heterodimerization activityIPI10473615 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisIEAneuron, axon, neurite (GO term level: 12)-
GO:0001764neuron migrationIEAneuron (GO term level: 8)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0006265DNA topological changeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000792heterochromatinIDA9049244 
GO:0005829cytosolIDA9049244 
GO:0005634nucleusIDA9049244 
GO:0005654nucleoplasmIDA9049244 
GO:0005694chromosomeIEA-
GO:0005730nucleolusIDA9049244 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAZ1BWBSCR10 | WBSCR9 | WSTFbromodomain adjacent to zinc finger domain, 1B-HPRD,BioGRID12837248 
CD3EFLJ18683 | T3E | TCRECD3e molecule, epsilon (CD3-TCR complex)-HPRD,BioGRID8626450 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptide-HPRD,BioGRID11710515 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11062478 |11136718 
HDAC2RPD3 | YAF1histone deacetylase 2Affinity Capture-Western
Reconstituted Complex		BioGRID11062478 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3ERK1 interacts with and phosphorylates Topoisomerase II-beta.BIND9155018 
MTA2DKFZp686F2281 | MTA1L1 | PIDmetastasis associated 1 family, member 2Affinity Capture-WesternBioGRID11062478 
SUMO1DAP-1 | GMP1 | OFC10 | PIC1 | SENP2 | SMT3 | SMT3C | SMT3H3 | SUMO-1 | UBL1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)-HPRD,BioGRID10862613 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDa-HPRD,BioGRID8710863 
TOPBP1TOP2BP1topoisomerase (DNA) II binding protein 1-HPRD,BioGRID9461304 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID10666337 
XPO1CRM1 | DKFZp686B1823exportin 1 (CRM1 homolog, yeast)-HPRD12821127 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_DNAFRAGMENT_PATHWAY 106All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
MANN_RESPONSE_TO_AMIFOSTINE_UP 2012All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_IMMORTALIZED_DN 3126All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN 165104All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
GOLUB_ALL_VS_AML_UP 2420All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_DN 5843All SZGR genes in this pathway
BURTON_ADIPOGENESIS_11 5740All SZGR genes in this pathway
BAELDE_DIABETIC_NEPHROPATHY_DN 434302All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6 5232All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
WENDT_COHESIN_TARGETS_UP 3319All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN 18197All SZGR genes in this pathway
YAGI_AML_WITH_T_9_11_TRANSLOCATION 13087All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_DN 6938All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-239298m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-32391981A,m8hsa-miR-323brainGCACAUUACACGGUCGACCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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