Gene Page: WNT1

Summary
GeneID  7471
Symbol  WNT1
Synonyms  INT1
Description  wingless-type MMTV integration site family, member 1
See related  HGNC:12774|MIM:164820|Ensembl:ENSG00000125084|HPRD:01276|
Locus tag  -
Gene type  protein-coding
Map location  12q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DHX150.950.97
GPBP10.950.96
PRPF4B0.950.97
PAPOLA0.950.96
SUZ120.950.97
MSH20.950.95
YME1L10.940.95
NUP1330.940.97
METTL140.940.94
UHRF20.940.96
Top 10 negatively co-expressed genes
MT-CO2-0.75-0.88
FXYD1-0.75-0.87
AF347015.31-0.74-0.86
AF347015.33-0.73-0.85
IFI27-0.73-0.86
AF347015.27-0.72-0.84
MT-CYB-0.72-0.84
AF347015.8-0.72-0.86
HLA-F-0.70-0.77
HIGD1B-0.70-0.84
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingNASNeurotransmitter (GO term level: 4)15592430 
GO:0004871signal transducer activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)2202907 
GO:0022004midbrain-hindbrain boundary maturation during brain developmentIEABrain (GO term level: 12)-
GO:0048664neuron fate determinationIEAneuron (GO term level: 10)-
GO:0001708cell fate specificationTAS15592430 
GO:0007223Wnt receptor signaling pathway, calcium modulating pathwayIEA-
GO:0007163establishment or maintenance of cell polarityTAS15592430 
GO:0007275multicellular organismal developmentIEA-
GO:0016477cell migrationTAS15592430 
GO:0030154cell differentiationTAS15592430 
GO:0042472inner ear morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005578proteinaceous extracellular matrixIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FZD8FZ-8 | hFZ8frizzled homolog 8 (Drosophila)Affinity Capture-WesternBioGRID11448771 
Frizzled-8 interacts with Wnt-1. This interaction was modeled on a demonstrated interaction between Frizzled-8 and Wnt-1 from unspecified species.BIND15454084 
FZD9CD349 | FZD3frizzled homolog 9 (Drosophila)-HPRD9147651 
LRP6ADCAD2 | FLJ90062 | FLJ90421low density lipoprotein receptor-related protein 6Affinity Capture-WesternBioGRID11448771 
RYKD3S3195 | JTK5 | JTK5A | RYK1RYK receptor-like tyrosine kinaseRyk interacts with Wnt-1. This interaction was modeled on a demonstrated interaction between Ryk and Wnt-1 from unspecified species.BIND15454084 
SFRP1FRP | FRP-1 | FRP1 | FrzA | SARP2secreted frizzled-related protein 1-HPRD,BioGRID10347172 
SFRP2FRP-2 | SARP1 | SDF-5secreted frizzled-related protein 2-HPRD10654605 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_WNT_SIGNALING_PATHWAY 151112All SZGR genes in this pathway
KEGG_HEDGEHOG_SIGNALING_PATHWAY 5642All SZGR genes in this pathway
KEGG_MELANOGENESIS 10280All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_BASAL_CELL_CARCINOMA 5544All SZGR genes in this pathway
BIOCARTA_ALK_PATHWAY 3729All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
BIOCARTA_PITX2_PATHWAY 1515All SZGR genes in this pathway
BIOCARTA_PS1_PATHWAY 1414All SZGR genes in this pathway
BIOCARTA_WNT_PATHWAY 2624All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
PID_PS1_PATHWAY 4639All SZGR genes in this pathway
PID_WNT_SIGNALING_PATHWAY 2823All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
THEODOROU_MAMMARY_TUMORIGENESIS 3124All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_6 119All SZGR genes in this pathway
NADLER_HYPERGLYCEMIA_AT_OBESITY 5835All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3 9772All SZGR genes in this pathway
DE_YY1_TARGETS_UP 2014All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_IPS_WITH_HCP_H3K27ME3 10276All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98227233m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-130/301260266m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-140168174m8hsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-148/152261267m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-19685691m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-34/449263269m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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