Gene Page: YY1

Summary
GeneID  7528
Symbol  YY1
Synonyms  DELTA|INO80S|NF-E1|UCRBP|YIN-YANG-1
Description  YY1 transcription factor
See related  HGNC:12856|MIM:600013|Ensembl:ENSG00000100811|HPRD:02482|
Locus tag  -
Gene type  protein-coding
Map location  14q
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0278 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MARK30.940.95
ZNF280D0.930.94
LEO10.930.95
ZNF7110.920.95
REV10.920.94
SCAPER0.910.94
TTC170.910.93
SR1400.910.94
C10orf1370.910.94
ZFP280.910.95
Top 10 negatively co-expressed genes
AF347015.31-0.82-0.88
MT-CO2-0.81-0.88
AF347015.27-0.81-0.87
AF347015.33-0.79-0.86
FXYD1-0.79-0.86
IFI27-0.79-0.87
MT-CYB-0.78-0.85
AF347015.8-0.78-0.87
HIGD1B-0.77-0.86
HLA-F-0.77-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS1946405 
GO:0003713transcription coactivator activityTAS1946405 
GO:0003714transcription corepressor activityTAS1655281 
GO:0005515protein bindingIPI9016636 
GO:0008270zinc ion bindingTAS1655281 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS1655281 
GO:0006350transcriptionIEA-
GO:0009952anterior/posterior pattern formationIEA-
GO:0048593camera-type eye morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005667transcription factor complexIEA-
GO:0005737cytoplasmIDA18029348 
GO:0005886plasma membraneIDA18029348 
GO:0016363nuclear matrixIEA-
GO:0031519PcG protein complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2YY1 interacts with ATF-2.BIND7769693 
ATF6ATF6Aactivating transcription factor 6-HPRD,BioGRID10866666 
ATF7ATFA | MGC57182activating transcription factor 7YY1 interacts with ATFa2.BIND7769693 
YY1 interacts with ATFa3.BIND7769693 
CDKN2AARF | CDK4I | CDKN2 | CMM2 | INK4 | INK4a | MLM | MTS1 | TP16 | p14 | p14ARF | p16 | p16INK4 | p16INK4a | p19cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)YY1 interacts with p14ARF.BIND15210108 
CREB1CREB | MGC9284cAMP responsive element binding protein 1YY1 interacts with CREB.BIND7769693 
DNAJB4DNAJW | DjB4 | HLJ1DnaJ (Hsp40) homolog, subfamily B, member 4YY1 interacts with HLJ1 YY1-binding site.BIND15782117 
E2F2E2F-2E2F transcription factor 2-HPRD12411495 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3-HPRD12411495 
EEDHEED | WAIT1embryonic ectoderm developmentYY1 interacts with EED.BIND14610174 
EED interacts with YY1.BIND11158321 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid		BioGRID7758944 |11486036 
EZH2ENX-1 | EZH1 | KMT6 | MGC9169enhancer of zeste homolog 2 (Drosophila)EED interacts with EZH2.BIND14610174 
FKBP1AFKBP-12 | FKBP1 | FKBP12 | FKBP12C | PKC12 | PKCI2 | PPIASEFK506 binding protein 1A, 12kDaTwo-hybridBioGRID7541038 
FKBP3FKBP-25 | PPIaseFK506 binding protein 3, 25kDaAffinity Capture-Western
Reconstituted Complex		BioGRID11532945 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, i-HPRD11287625 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Reconstituted ComplexBioGRID9346952 
HDAC2RPD3 | YAF1histone deacetylase 2YY1 interacts with RPD3. This interaction was modelled on a demonstrated interaction between human YY1 and mouse RPD3.BIND8917507 
-HPRD,BioGRID11486036 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3-HPRD,BioGRID9346952 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BBiochemical ActivityBioGRID11486036 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)YY1 interacts with Hdm2.BIND15210108 
MTA2DKFZp686F2281 | MTA1L1 | PIDmetastasis associated 1 family, member 2Reconstituted ComplexBioGRID12920132 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID8266081 
NOTCH1TAN1 | hN1Notch homolog 1, translocation-associated (Drosophila)-HPRD,BioGRID12913000 
RYBPAAP1 | DEDAF | YEAF1RING1 and YY1 binding protein-HPRD,BioGRID10369680 
SAP30-Sin3A-associated protein, 30kDa-HPRD,BioGRID12788099 
SP1-Sp1 transcription factorAffinity Capture-WesternBioGRID10224053 
YY1 interacts with Sp1.BIND8327494 
SREBF1SREBP-1c | SREBP1 | bHLHd1sterol regulatory element binding transcription factor 1Reconstituted ComplexBioGRID10224053 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53YY1 interacts with p53.BIND15210108 
YAF2MGC41856YY1 associated factor 2-HPRD,BioGRID9016636 
ZRANB2DKFZp686J1831 | DKFZp686N09117 | FLJ41119 | ZIS | ZIS1 | ZIS2 | ZNF265zinc finger, RAN-binding domain containing 2-HPRD11448987 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NOTCH_PATHWAY 5949All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_DN 6849All SZGR genes in this pathway
CHANDRAN_METASTASIS_TOP50_UP 3827All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
AMIT_EGF_RESPONSE_240_HELA 6043All SZGR genes in this pathway
CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP 106All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN 225163All SZGR genes in this pathway
FAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN 4826All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP 8366All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C2 5439All SZGR genes in this pathway
MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_DN 5430All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D8 4029All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CROONQUIST_STROMAL_STIMULATION_DN 137All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_DN 187109All SZGR genes in this pathway
WANG_TNF_TARGETS 2417All SZGR genes in this pathway
YUAN_ZNF143_PARTNERS 2215All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-141/200a6696751Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-5p2963021Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-1817897951Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1862933001A,m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-29774780m8hsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-34/4497207261Ahsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-3816056111Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-3849096m8hsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-4105465531A,m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-433-3p2692751Ahsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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