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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: YWHAH

Summary

GeneID

7533

Symbol

YWHAH

Synonyms

YWHA1

Description

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide

Locus tag

LL22NC03-44A4.1

Gene type

protein-coding

Map location

22q12.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

GSMA_I

genome scan meta-analysis

Psr: 0.031

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 3

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.989

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ZNF845

0.96

0.90

SMARCAD1

0.95

0.92

ZNF670

0.95

0.90

ZNF468

0.95

0.91

TRIM13

0.94

0.83

ZNF555

0.94

0.86

CCDC50

0.94

0.87

PHF16

0.94

0.88

GNA13

0.94

0.89

TNPO1

0.94

0.91

Top 10 negatively co-expressed genes

C5orf53

-0.67

-0.74

HLA-F

-0.66

-0.75

FBXO2

-0.64

-0.66

AIFM3

-0.63

-0.71

PTH1R

-0.63

-0.70

AC018755.7

-0.63

-0.70

SLC16A11

-0.63

-0.64

LHPP

-0.63

-0.58

AF347015.27

-0.63

-0.81

TNFSF12

-0.62

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003779

actin binding

IEA

GO:0003779

actin binding

ISS

GO:0005159

insulin-like growth factor receptor binding

ISS

GO:0019904

protein domain specific binding

ISS

GO:0016563

transcription activator activity

IDA

15790729

GO:0035259

glucocorticoid receptor binding

IPI

9079630

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0048167

regulation of synaptic plasticity

ISS

Synap (GO term level: 8)

GO:0050774

negative regulation of dendrite morphogenesis

ISS

neurogenesis, dendrite (GO term level: 14)

GO:0045664

regulation of neuron differentiation

ISS

neuron, neurogenesis (GO term level: 9)

GO:0006713

glucocorticoid catabolic process

IDA

15790729

GO:0006886

intracellular protein transport

ISS

GO:0042921

glucocorticoid receptor signaling pathway

IDA

15790729

GO:0045941

positive regulation of transcription

IDA

15790729

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

ISS

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	c-Abl interacts with 14-3-3-eta.	BIND	15696159
ARAF	A-RAF \| ARAF1 \| PKS2 \| RAFA1	v-raf murine sarcoma 3611 viral oncogene homolog	Affinity Capture-Western	BioGRID	11969417
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	-	HPRD,BioGRID	9369453
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	-	HPRD	8668348
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	-	HPRD,BioGRID	10713667
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD	9278512 \|10330186
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	Affinity Capture-Western	BioGRID	11969417
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD	12042314
CHRNA4	BFNC \| EBN \| EBN1 \| FLJ95812 \| NACHR \| NACHRA4 \| NACRA4	cholinergic receptor, nicotinic, alpha 4	-	HPRD,BioGRID	11352901
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD	11266503
EPB41L3	4.1B \| DAL-1 \| DAL1 \| FLJ37633 \| KIAA0987	erythrocyte membrane protein band 4.1-like 3	-	HPRD,BioGRID	11996670
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD	11266503
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD	11266503
IRS1	HIRS-1	insulin receptor substrate 1	Affinity Capture-Western	BioGRID	11969417
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	JNK interacts with 14-3-3-eta.	BIND	15696159
KCNH2	ERG1 \| HERG \| HERG1 \| Kv11.1 \| LQT2 \| SQT1	potassium voltage-gated channel, subfamily H (eag-related), member 2	-	HPRD	11953308
KIF5B	KINH \| KNS \| KNS1 \| UKHC	kinesin family member 5B	Affinity Capture-MS Far Western	BioGRID	11969417
KLC3	KLC2 \| KLC2L \| KLCt \| KNS2B	kinesin light chain 3	-	HPRD,BioGRID	11969417
KRT18	CYK18 \| K18	keratin 18	-	HPRD	9524113
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	11266503
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD	11266503
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	-	HPRD	11266503
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	-	HPRD	11266503
NEK1	DKFZp686D06121 \| DKFZp686K12169 \| KIAA1901 \| MGC138800 \| NY-REN-55	NIMA (never in mitosis gene a)-related kinase 1	NEK1 interacts with 14-3-3.	BIND	14690447
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	9079630 \|11266503 \|12730237
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD	11266503
PCTK1	FLJ16665 \| PCTAIRE \| PCTAIRE1 \| PCTGAIRE	PCTAIRE protein kinase 1	-	HPRD	9799109
PDK1	-	pyruvate dehydrogenase kinase, isozyme 1	-	HPRD	12177059
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	-	HPRD,BioGRID	12177059
PIAS2	MGC102682 \| MIZ1 \| PIASX \| PIASX-ALPHA \| PIASX-BETA \| SIZ2 \| ZMIZ4 \| miz	protein inhibitor of activated STAT, 2	Miz1 interacts with 14-3-3 eta.	BIND	15580267
PIK3CA	MGC142161 \| MGC142163 \| PI3K \| p110-alpha	phosphoinositide-3-kinase, catalytic, alpha polypeptide	Affinity Capture-Western	BioGRID	11969417
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	Affinity Capture-Western	BioGRID	10620507
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	8702721
REM1	GD:REM \| GES \| MGC48669 \| REM	RAS (RAD and GEM)-like GTP-binding 1	-	HPRD,BioGRID	10441394
RGNEF	DKFZp686P12164 \| FLJ21817 \| KIAA1998	Rho-guanine nucleotide exchange factor	-	HPRD	11533041
RIMS1	CORD7 \| KIAA0340 \| MGC167823 \| MGC176677 \| RAB3IP2 \| RIM \| RIM1	regulating synaptic membrane exocytosis 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12871946
RIMS2	DKFZp781A0653 \| KIAA0751 \| OBOE \| RAB3IP3 \| RIM2	regulating synaptic membrane exocytosis 2	-	HPRD,BioGRID	12871946
RPH3A	KIAA0985	rabphilin 3A homolog (mouse)	-	HPRD,BioGRID	12871946
SNRPE	B-raf \| SME	small nuclear ribonucleoprotein polypeptide E	Affinity Capture-Western	BioGRID	11969417
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	8702721
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	-	HPRD	11266503
TLX2	Enx \| HOX11L1 \| NCX	T-cell leukemia homeobox 2	-	HPRD,BioGRID	9738002
TNFAIP3	A20 \| MGC104522 \| MGC138687 \| MGC138688 \| OTUD7C \| TNFA1P2	tumor necrosis factor, alpha-induced protein 3	-	HPRD,BioGRID	8702721 \|9299557
TPH1	MGC119994 \| TPH \| TPRH	tryptophan hydroxylase 1	-	HPRD	7499362
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Hamartin interacts with 14-3-3-eta. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-eta isoform.	BIND	12176984
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD	12438239
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	The tumor suppressor protein tuberin interacts with 14-3-3-eta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-eta isoform.	BIND	12176984
ZFP36	G0S24 \| GOS24 \| NUP475 \| RNF162A \| TIS11 \| TTP	zinc finger protein 36, C3H type, homolog (mouse)	-	HPRD,BioGRID	11886850

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_CELL_CYCLE	128	84	All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS	114	79	All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY	126	103	All SZGR genes in this pathway
BIOCARTA_AKT_PATHWAY	22	16	All SZGR genes in this pathway
BIOCARTA_G2_PATHWAY	24	20	All SZGR genes in this pathway
BIOCARTA_HDAC_PATHWAY	32	25	All SZGR genes in this pathway
BIOCARTA_IGF1R_PATHWAY	23	20	All SZGR genes in this pathway
BIOCARTA_RB_PATHWAY	13	11	All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY	42	35	All SZGR genes in this pathway
BIOCARTA_BAD_PATHWAY	26	23	All SZGR genes in this pathway
BIOCARTA_PGC1A_PATHWAY	26	20	All SZGR genes in this pathway
BIOCARTA_ACH_PATHWAY	16	13	All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	67	54	All SZGR genes in this pathway
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	51	41	All SZGR genes in this pathway
ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	37	29	All SZGR genes in this pathway
PID_LKB1_PATHWAY	47	37	All SZGR genes in this pathway
PID_NFAT_3PATHWAY	54	47	All SZGR genes in this pathway
PID_REG_GR_PATHWAY	82	60	All SZGR genes in this pathway
PID_MTOR_4PATHWAY	69	55	All SZGR genes in this pathway
PID_FOXO_PATHWAY	49	43	All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY	105	78	All SZGR genes in this pathway
PID_PDGFRB_PATHWAY	129	103	All SZGR genes in this pathway
PID_P38_MK2_PATHWAY	21	19	All SZGR genes in this pathway
PID_BETA_CATENIN_NUC_PATHWAY	80	60	All SZGR genes in this pathway
PID_A6B1_A6B4_INTEGRIN_PATHWAY	46	35	All SZGR genes in this pathway
PID_INSULIN_GLUCOSE_PATHWAY	26	24	All SZGR genes in this pathway
PID_PI3KCI_AKT_PATHWAY	35	30	All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY	36	31	All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN	663	425	All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_UP	290	177	All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	1278	748	All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN	1375	806	All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN	508	354	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP	358	245	All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN	1024	594	All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX	795	478	All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	206	136	All SZGR genes in this pathway
DEN_INTERACT_WITH_LCA5	26	21	All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS	775	494	All SZGR genes in this pathway
BENPORATH_CYCLING_GENES	648	385	All SZGR genes in this pathway
GNATENKO_PLATELET_SIGNATURE	48	28	All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN	187	122	All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN	309	206	All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	555	346	All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP	69	41	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
RAMALHO_STEMNESS_UP	206	118	All SZGR genes in this pathway
MOREIRA_RESPONSE_TO_TSA_UP	28	23	All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C0	107	72	All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_TBH	60	42	All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN	32	25	All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN	161	105	All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP	566	371	All SZGR genes in this pathway
GHO_ATF5_TARGETS_DN	16	10	All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST	132	93	All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP	180	114	All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN	202	132	All SZGR genes in this pathway
GRADE_COLON_CANCER_UP	871	505	All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_DN	175	103	All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN	142	79	All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN	238	145	All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK	1210	725	All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES	389	245	All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP	181	106	All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2	277	172	All SZGR genes in this pathway
DANG_BOUND_BY_MYC	1103	714	All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2_M	216	124	All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D	658	397	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	792	798	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	792	798	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-129-5p	397	403	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	397	403	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-142-5p	493	499	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497	793	799	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-219	67	73	1A	hsa-miR-219^brain	UGAUUGUCCAAACGCAAUUCU
miR-31	61	67	1A	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-33	582	588	m8	hsa-miR-33	GUGCAUUGUAGUUGCAUUG
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
				hsa-miR-33	GUGCAUUGUAGUUGCAUUG
				hsa-miR-33b	GUGCAUUGCUGUUGCAUUGCA
miR-338	172	178	1A	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA
miR-365	166	172	m8	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU
miR-450	397	403	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.