Gene Page: CACNA1B

Summary
GeneID  774
Symbol  CACNA1B
Synonyms  BIII|CACNL1A5|CACNN|Cav2.2
Description  calcium channel, voltage-dependent, N type, alpha 1B subunit
See related  HGNC:1389|MIM:601012|HPRD:03005|
Locus tag  -
Gene type  protein-coding
Map location  9q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ITPKA0.870.86
CA110.830.88
TMEM38A0.830.85
ACOT40.820.84
RUNDC3A0.820.73
ENSA0.820.69
TUBA10.810.87
ST6GALNAC60.810.81
ADAP10.810.76
CAMK2N10.810.73
Top 10 negatively co-expressed genes
KIAA1949-0.63-0.66
TUBB2B-0.63-0.71
FADS2-0.61-0.67
SH3BP2-0.61-0.72
ZNF311-0.60-0.61
KCTD11-0.60-0.70
JUP-0.59-0.63
COTL1-0.59-0.62
ZNF193-0.59-0.63
TIGD1-0.59-0.63
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005524ATP bindingIEA-
GO:0005244voltage-gated ion channel activityIEA-
GO:0005245voltage-gated calcium channel activityIEA-
GO:0005245voltage-gated calcium channel activityTAS1321501 
GO:0008022protein C-terminus bindingIPI15728831 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9030575 
GO:0006816calcium ion transportIEA-
GO:0006811ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneEXP8825650 
GO:0005891voltage-gated calcium channel complexTAS1321501 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CACNA1BBIII | CACNL1A5 | CACNN | Cav2.2calcium channel, voltage-dependent, N type, alpha 1B subunitCav2.2 interacts with itself.BIND15953418 
CACNB3CACNLB3calcium channel, voltage-dependent, beta 3 subunit-HPRD12161429 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)The SH3 domain of CASK interacts with the carboxy-terminal proline-rich region (PRR) of Ca-alpha-1B.BIND10455105 
GNAO1DKFZp686O0962 | G-ALPHA-o | GNAOguanine nucleotide binding protein (G protein), alpha activating activity polypeptide OReconstituted ComplexBioGRID11395521 
GNB1-guanine nucleotide binding protein (G protein), beta polypeptide 1Cav2.2 interacts with G-beta-1. This interaction was modeled on a demonstrated interaction between human Cav2.2 and G-beta-1 from an unspecified species.BIND15953418 
PDLIM5ENH | ENH1 | L9 | LIMPDZ and LIM domain 5-HPRD,BioGRID12665800 
RGS12DKFZp761K1617 | DKFZp761K1817regulator of G-protein signaling 12-HPRD11130074 
SLC44A1CD92 | CDW92 | CHTL1 | CTL1 | RP11-287A8.1solute carrier family 44, member 1-HPRD15728831 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_TASTE_TRANSDUCTION 5228All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_UP 398262All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_UP 249170All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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