Gene Page: USP7

Summary
GeneID  7874
Symbol  USP7
Synonyms  HAUSP|TEF1
Description  ubiquitin specific peptidase 7 (herpes virus-associated)
See related  HGNC:12630|MIM:602519|Ensembl:ENSG00000187555|HPRD:03950|
Locus tag  -
Gene type  protein-coding
Map location  16p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.172 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C7orf200.900.89
RMND5B0.890.88
DPH20.880.87
VAC140.870.87
B4GALNT10.870.88
AGPAT10.870.88
RNF310.870.83
RNF1230.870.85
DHX300.860.85
CCDC220.860.83
Top 10 negatively co-expressed genes
AF347015.21-0.69-0.68
AF347015.8-0.68-0.64
MT-CO2-0.67-0.62
AL139819.3-0.67-0.70
AF347015.31-0.66-0.62
AF347015.27-0.66-0.64
MT-CYB-0.65-0.62
AF347015.33-0.65-0.61
AF347015.2-0.64-0.58
AF347015.26-0.64-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004197cysteine-type endopeptidase activityTAS9827704 
GO:0004221ubiquitin thiolesterase activityIEA-
GO:0008022protein C-terminus bindingIPI12093161 
GO:0008234cysteine-type peptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0016579protein deubiquitinationIMP11923872 
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12093161 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATXN1ATX1 | D6S504E | SCA1ataxin 1-HPRD,BioGRID12093161 
MAGEB2DAM6 | MAGE-XP-2 | MGC26438melanoma antigen family B, 2Affinity Capture-MSBioGRID17353931 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)Mdm2 interacts with HAUSP. This interaction was modeled on a demonstrated interaction between Mdm2 from an unspecified species and human HAUSP.BIND15916963 
MDM4DKFZp781B1423 | HDMX | MDMX | MGC132766 | MRP1Mdm4 p53 binding protein homolog (mouse)Hdmx interacts with HAUSP.BIND15916963 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)Affinity Capture-MSBioGRID17353931 
TANKI-TRAF | TRAF2TRAF family member-associated NFKB activator-HPRD,BioGRID11279055 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11923872 
p53 interacts with HAUSP.BIND15916963 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1-HPRD,BioGRID11279055 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID11279055 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3-HPRD,BioGRID11279055 
TRAF4CART1 | MLN62 | RNF83TNF receptor-associated factor 4-HPRD,BioGRID11279055 
TRAF5MGC:39780 | RNF84TNF receptor-associated factor 5-HPRD,BioGRID11279055 
TRAF6MGC:3310 | RNF85TNF receptor-associated factor 6-HPRD,BioGRID11279055 
USP7HAUSP | TEF1ubiquitin specific peptidase 7 (herpes virus-associated)-HPRD12507430 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS 290172All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS 734436All SZGR genes in this pathway
BENPORATH_NOS_TARGETS 179105All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
STARK_HYPPOCAMPUS_22Q11_DELETION_UP 5340All SZGR genes in this pathway
STARK_BRAIN_22Q11_DELETION 1310All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 4130All SZGR genes in this pathway
KENNY_CTNNB1_TARGETS_DN 5234All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
JOSEPH_RESPONSE_TO_SODIUM_BUTYRATE_DN 6445All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
GRADE_COLON_AND_RECTAL_CANCER_UP 285167All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1402372431Ahsa-miR-140brainAGUGGUUUUACCCUAUGGUAG
miR-409-5p2342411A,m8hsa-miR-409-5pAGGUUACCCGAGCAACUUUGCA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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