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Gene Page: CASP3

Summary

GeneID

836

Symbol

CASP3

Synonyms

CPP32|CPP32B|SCA-1

Description

caspase 3, apoptosis-related cysteine peptidase

Locus tag

Gene type

protein-coding

Map location

4q34

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.3923

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SEPT2

0.75

0.70

ITGA6

0.75

0.69

CDC14A

0.74

0.71

HSDL2

0.74

0.70

SNX5

0.73

0.72

SUCLG2

0.72

0.73

PPAP2B

0.72

0.76

MSI2

0.72

0.66

PSAT1

0.72

0.77

PLOD2

0.71

0.69

Top 10 negatively co-expressed genes

RTN4RL1

-0.37

-0.32

LRFN2

-0.36

-0.32

MPPED1

-0.35

-0.31

ARHGAP20

-0.35

-0.28

SLC26A4

-0.34

RASGEF1C

-0.34

-0.29

AC093307.1

-0.34

-0.28

MYT1L

-0.34

-0.27

CECR6

-0.34

-0.29

MEF2C

-0.34

-0.30

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

9736630

GO:0004861

cyclin-dependent protein kinase inhibitor activity

IEA

GO:0004197

cysteine-type endopeptidase activity

IEA

GO:0004197

cysteine-type endopeptidase activity

TAS

10942389

GO:0008233

peptidase activity

IDA

9353287

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0051402

neuron apoptosis

IEA

neuron, axon, dendrite (GO term level: 7)

GO:0001836

release of cytochrome c from mitochondria

IEA

GO:0001782

B cell homeostasis

IEA

GO:0006309

DNA fragmentation during apoptosis

IEA

GO:0030264

nuclear fragmentation during apoptosis

IMP

11350920

GO:0008625

induction of apoptosis via death domain receptors

IEA

GO:0006508

proteolysis

IDA

12888622

GO:0006508

proteolysis

IEA

GO:0006917

induction of apoptosis

TAS

7983002

GO:0008631

induction of apoptosis by oxidative stress

IEA

GO:0009611

response to wounding

IEA

GO:0007507

heart development

IEA

GO:0007605

sensory perception of sound

IEA

GO:0009411

response to UV

IEA

GO:0006915

apoptosis

IEA

GO:0043066

negative regulation of apoptosis

IGI

9353287

GO:0030216

keratinocyte differentiation

IEA

GO:0030889

negative regulation of B cell proliferation

IEA

GO:0043029

T cell homeostasis

IEA

GO:0045165

cell fate commitment

IEA

GO:0045736

negative regulation of cyclin-dependent protein kinase activity

IEA

GO:0046007

negative regulation of activated T cell proliferation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

8976194 |9624143 |10490026
|10748026 |10823823
|11106668 |11313965
|11500511 |11689006
|16983089

GO:0005829

cytosol

IDA

17823127

GO:0005634

nucleus

IDA

18029348

GO:0005654

nucleoplasm

EXP

9108473

GO:0005730

nucleolus

IDA

18029348

GO:0005737

cytoplasm

IDA

18029348

GO:0005737

cytoplasm

IEA

GO:0005739

mitochondrion

IDA

18029348

GO:0005886

plasma membrane

EXP

11076937 |16286477

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Androgen Receptor interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 3 from an unspecified species.	BIND	9535906
ATN1	B37 \| D12S755E \| DRPLA \| NOD	atrophin 1	Atrophin-1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 3 from an unspecified species.	BIND	9535906
ATXN3	AT3 \| ATX3 \| JOS \| MJD \| MJD1 \| SCA3	ataxin 3	Ataxin-3 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 3 from an unspecified species.	BIND	9535906
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	11948397
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Biochemical Activity	BioGRID	11399776
BIRC2	API1 \| HIAP2 \| Hiap-2 \| MIHB \| RNF48 \| cIAP1	baculoviral IAP repeat-containing 2	-	HPRD,BioGRID	9384571
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	cIAP2 exhibits E3 ubiquitin ligase activity towards Casp3.	BIND	10862606
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	-	HPRD,BioGRID	9384571
BIRC5	API4 \| EPR-1	baculoviral IAP repeat-containing 5	-	HPRD,BioGRID	9850056
BIRC6	APOLLON \| BRUCE \| FLJ13726 \| FLJ13786 \| KIAA1289	baculoviral IAP repeat-containing 6	BRUCE interacts with Casp-3. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-3.	BIND	15200957
BIRC7	KIAP \| LIVIN \| ML-IAP \| MLIAP \| RNF50	baculoviral IAP repeat-containing 7	-	HPRD,BioGRID	11024045
BLM	BS \| MGC126616 \| MGC131618 \| MGC131620 \| RECQ2 \| RECQL2 \| RECQL3	Bloom syndrome	Biochemical Activity	BioGRID	11470874
BMX	ETK \| PSCTK2 \| PSCTK3	BMX non-receptor tyrosine kinase	-	HPRD,BioGRID	11278797
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078
CASP2	CASP-2 \| ICH-1L \| ICH-1L/1S \| ICH1 \| NEDD2	caspase 2, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	11399776
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	-	HPRD,BioGRID	11257232
CASP6	MCH2	caspase 6, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8900201
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Biochemical Activity	BioGRID	8962078 \|11832478
CASP9	APAF-3 \| APAF3 \| CASPASE-9c \| ICE-LAP6 \| MCH6	caspase 9, apoptosis-related cysteine peptidase	-	HPRD	11230124
CDC2L2	CDC2L3 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| MGC131975 \| PITSLRE \| p58GTA	cell division cycle 2-like 2 (PITSLRE proteins)	-	HPRD	9632733
CFLAR	CASH \| CASP8AP1 \| CLARP \| Casper \| FLAME \| FLAME-1 \| FLAME1 \| FLIP \| I-FLICE \| MRIT \| c-FLIP \| c-FLIPL \| c-FLIPR \| c-FLIPS	CASP8 and FADD-like apoptosis regulator	-	HPRD,BioGRID	9208847
			MRIT-beta-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and YAMA from an unspecified species.	BIND	9326610
			MRIT-alpha-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and YAMA from an unspecified species.	BIND	9326610
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	9348292
CTTN	EMS1 \| FLJ34459	cortactin	Biochemical Activity	BioGRID	11689006
DBNL	ABP1 \| HIP-55 \| SH3P7	drebrin-like	Biochemical Activity	BioGRID	11689006
DCC	CRC18 \| CRCR1	deleted in colorectal carcinoma	-	HPRD,BioGRID	11248093
DCTN1	DAP-150 \| DP-150 \| HMN7B \| P135	dynactin 1 (p150, glued homolog, Drosophila)	-	HPRD	11425872
DEDD	CASP8IP1 \| DEDD1 \| DEFT \| FLDED1 \| KE05	death effector domain containing	-	HPRD	12235123
DFFA	DFF-45 \| DFF1 \| ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	-	HPRD	11752060
EIF4B	EIF-4B \| PRO1843	eukaryotic translation initiation factor 4B	-	HPRD	11274152
GORASP1	FLJ23443 \| GOLPH5 \| GRASP65 \| MGC118894 \| MGC118897 \| P65	golgi reassembly stacking protein 1, 65kDa	-	HPRD,BioGRID	11815631
HCLS1	CTTNL \| HS1	hematopoietic cell-specific Lyn substrate 1	-	HPRD,BioGRID	11689006 \|11988074
HSPD1	CPN60 \| GROEL \| HSP60 \| HSP65 \| HuCHA60 \| SPG13	heat shock 60kDa protein 1 (chaperonin)	-	HPRD,BioGRID	10205158 \|10205159
HSPE1	CPN10 \| GROES \| HSP10	heat shock 10kDa protein 1 (chaperonin 10)	-	HPRD,BioGRID	10205158
HTT	HD \| IT15	huntingtin	Huntingtin interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human Huntingtin and caspase 3 from an unspecified species.	BIND	9535906
KCNIP3	CSEN \| DREAM \| KCHIP3 \| MGC18289	Kv channel interacting protein 3, calsenilin	-	HPRD	11278424
LMNB1	ADLD \| LMN \| LMN2 \| LMNB \| MGC111419	lamin B1	-	HPRD	11901153
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	Affinity Capture-Western	BioGRID	11002417
MCL1	BCL2L3 \| EAT \| MCL1L \| MCL1S \| MGC104264 \| MGC1839 \| TM	myeloid cell leukemia sequence 1 (BCL2-related)	Biochemical Activity	BioGRID	15637055
NDUFS1	CI-75Kd \| MGC26839 \| PRO1304	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	NDUFS1 interacts with caspase-3. This interaction was modeled on a demonstrated interaction between human NDUSF1 and caspase-3 from an unspecified source.	BIND	15186778
NEO1	DKFZp547A066 \| DKFZp547B146 \| HsT17534 \| NGN	neogenin homolog 1 (chicken)	Neogenin interacts with Caspase 3. This interaction was modelled on a demonstrated interaction between human Neogenin and Caspase 3 from an unspecified species.	BIND	15258591
NFE2L2	NRF2	nuclear factor (erythroid-derived 2)-like 2	-	HPRD,BioGRID	10510468
PARG	PARG99	poly (ADP-ribose) glycohydrolase	-	HPRD,BioGRID	11053413
PARP1	ADPRT \| ADPRT1 \| PARP \| PARP-1 \| PPOL \| pADPRT-1	poly (ADP-ribose) polymerase 1	PARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source.	BIND	15186778
PDE10A	FLJ11894 \| FLJ25677 \| HSPDE10A	phosphodiesterase 10A	-	HPRD	11602184
PICALM	CALM \| CLTH \| LAP	phosphatidylinositol binding clathrin assembly protein	-	HPRD	10926122
PLEKHO1	CKIP-1 \| OC120	pleckstrin homology domain containing, family O member 1	CKIP-1 is cleaved by CASP3 during the initiation of apoptosis.	BIND	15706351
PPP3CA	CALN \| CALNA \| CALNA1 \| CCN1 \| CNA1 \| PPP2B	protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform	-	HPRD	11478781
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 3.	BIND	10069390
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	CASP3 (caspase-3) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p100, p68, p61 and p48 forms.	BIND	15735701
SARS2	FLJ20450 \| SARS \| SARSM \| SERS \| SYS \| SerRSmt \| mtSerRS	seryl-tRNA synthetase 2, mitochondrial	-	HPRD	11331419
SLK	KIAA0204 \| LOSK \| MGC133067 \| STK2 \| bA16H23.1 \| se20-9	STE20-like kinase (yeast)	-	HPRD	10611247
SREBF2	SREBP2 \| bHLHd2	sterol regulatory element binding transcription factor 2	-	HPRD,BioGRID	8605870
SRP72	-	signal recognition particle 72kDa	-	HPRD	9857079
TGM2	G-ALPHA-h \| GNAH \| TG2 \| TGC	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	-	HPRD	10556977
TNS4	CTEN \| FLJ14950 \| PP14434	tensin 4	Caspase-3 interacts with and cleaves cten.	BIND	15806167
TRAF1	EBI6 \| MGC:10353	TNF receptor-associated factor 1	-	HPRD	11098060
TRAF3	CAP-1 \| CD40bp \| CRAF1 \| LAP1	TNF receptor-associated factor 3	-	HPRD,BioGRID	11261798
USO1	P115 \| TAP \| VDP	USO1 homolog, vesicle docking protein (yeast)	-	HPRD,BioGRID	12438416
XIAP	API3 \| BIRC4 \| ILP1 \| MIHA \| XLP2	X-linked inhibitor of apoptosis	-	HPRD	9230442 \|11447297 \|11927604
			XIAP interacts with Casp-3.	BIND	15200957
			Affinity Capture-Western Co-crystal Structure in vitro in vivo Reconstituted Complex	BioGRID	9230442 \|9384571 \|11257232 \|11447297 \|11927604
			Caspase-3 interacts with XIAP.	BIND	15650747

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY	69	45	All SZGR genes in this pathway
KEGG_APOPTOSIS	88	62	All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	137	92	All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE	169	110	All SZGR genes in this pathway
KEGG_PARKINSONS_DISEASE	133	78	All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	53	43	All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE	185	109	All SZGR genes in this pathway
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	68	44	All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER	328	259	All SZGR genes in this pathway
KEGG_COLORECTAL_CANCER	62	47	All SZGR genes in this pathway
KEGG_VIRAL_MYOCARDITIS	73	58	All SZGR genes in this pathway
BIOCARTA_DNAFRAGMENT_PATHWAY	10	6	All SZGR genes in this pathway
BIOCARTA_CHEMICAL_PATHWAY	22	15	All SZGR genes in this pathway
BIOCARTA_BCELLSURVIVAL_PATHWAY	16	10	All SZGR genes in this pathway
BIOCARTA_CASPASE_PATHWAY	23	15	All SZGR genes in this pathway
BIOCARTA_D4GDI_PATHWAY	13	8	All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY	30	22	All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY	58	43	All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY	33	24	All SZGR genes in this pathway
BIOCARTA_MITOCHONDRIA_PATHWAY	21	15	All SZGR genes in this pathway
BIOCARTA_HSP27_PATHWAY	15	11	All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY	29	21	All SZGR genes in this pathway
ST_TUMOR_NECROSIS_FACTOR_PATHWAY	29	20	All SZGR genes in this pathway
SA_CASPASE_CASCADE	19	13	All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY	27	23	All SZGR genes in this pathway
SA_FAS_SIGNALING	9	5	All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY	65	54	All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY	66	53	All SZGR genes in this pathway
PID_NFAT_TFPATHWAY	47	39	All SZGR genes in this pathway
PID_FAS_PATHWAY	38	29	All SZGR genes in this pathway
PID_NFAT_3PATHWAY	54	47	All SZGR genes in this pathway
PID_AJDISS_2PATHWAY	48	38	All SZGR genes in this pathway
PID_P75_NTR_PATHWAY	69	51	All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY	35	26	All SZGR genes in this pathway
PID_CASPASE_PATHWAY	52	39	All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY	33	27	All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS	40	26	All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF	217	167	All SZGR genes in this pathway
REACTOME_SIGNALING_BY_HIPPO	22	15	All SZGR genes in this pathway
REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION	13	10	All SZGR genes in this pathway
REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS	13	11	All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS	12	6	All SZGR genes in this pathway
REACTOME_REGULATION_OF_APOPTOSIS	58	34	All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	60	43	All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING	81	61	All SZGR genes in this pathway
REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS	10	5	All SZGR genes in this pathway
REACTOME_APOPTOSIS	148	94	All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS	30	21	All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE	54	37	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_BLUE_UP	136	80	All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP	456	228	All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP	544	308	All SZGR genes in this pathway
GRAHAM_CML_QUIESCENT_VS_NORMAL_QUIESCENT_UP	87	45	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP	128	95	All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP	117	84	All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_CDC25_UP	58	39	All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP	536	340	All SZGR genes in this pathway
MARKS_HDAC_TARGETS_UP	23	15	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_UP	28	16	All SZGR genes in this pathway
BAKER_HEMATOPOESIS_STAT1_TARGETS	10	9	All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA	43	31	All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP	309	199	All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP	108	69	All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK	1652	1023	All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK	1442	892	All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP	209	139	All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_DN	103	71	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	206	136	All SZGR genes in this pathway
BENPORATH_ES_1	379	235	All SZGR genes in this pathway
BENPORATH_CYCLING_GENES	648	385	All SZGR genes in this pathway
COLLIS_PRKDC_REGULATORS	15	10	All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_UP	52	40	All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS	66	48	All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN	366	238	All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_DN	19	14	All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP	314	201	All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN	228	146	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT	51	41	All SZGR genes in this pathway
GENTILE_UV_HIGH_DOSE_DN	312	203	All SZGR genes in this pathway
SONG_TARGETS_OF_IE86_CMV_PROTEIN	60	42	All SZGR genes in this pathway
GENTILE_UV_RESPONSE_CLUSTER_D1	18	13	All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_DN	96	71	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5	482	296	All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3	160	103	All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED	728	415	All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN	108	64	All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP	223	132	All SZGR genes in this pathway
QI_PLASMACYTOMA_UP	259	185	All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE	346	192	All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C	69	49	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP	338	225	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP	418	282	All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN	245	150	All SZGR genes in this pathway
CHANG_CYCLING_GENES	148	83	All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP	163	102	All SZGR genes in this pathway
SHAFFER_IRF4_MULTIPLE_MYELOMA_PROGRAM	36	25	All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_MYELOMA_VS_MATURE_B_LYMPHOCYTE	101	76	All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_PLASMA_CELL_VS_MATURE_B_LYMPHOCYTE	67	51	All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_B_LYMPHOCYTE	81	66	All SZGR genes in this pathway
SHAFFER_IRF4_TARGETS_IN_ACTIVATED_DENDRITIC_CELL	65	49	All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_DN	253	192	All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G2	182	102	All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN	1972	1213	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN	336	211	All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP	259	159	All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP	682	433	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP	570	339	All SZGR genes in this pathway
ABDELMOHSEN_ELAVL4_TARGETS	16	13	All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B	517	302	All SZGR genes in this pathway
BOSCO_ALLERGEN_INDUCED_TH2_ASSOCIATED_MODULE	151	86	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	153	160	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-138	759	765	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-30-5p	1188	1194	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.