Gene Page: CASP4

Summary
GeneID  837
Symbol  CASP4
Synonyms  ICE(rel)II|ICEREL-II|ICH-2|Mih1/TX|TX
Description  caspase 4, apoptosis-related cysteine peptidase
See related  HGNC:1505|MIM:602664|Ensembl:ENSG00000196954|HPRD:04047|
Locus tag  -
Gene type  protein-coding
Map location  11q22.2-q22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.6047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DNAH70.610.49
SPAG10.570.42
DNAH120.550.40
KIAA15290.550.41
DNAH20.550.42
CCDC650.540.41
DNAH60.540.39
WDR660.540.41
FAM154B0.540.39
WDR520.540.40
Top 10 negatively co-expressed genes
TAF10-0.29-0.37
FAM128A-0.28-0.36
NRL-0.28-0.27
AF347015.21-0.27-0.19
UQCR-0.27-0.34
SERF2-0.26-0.30
FAM128B-0.26-0.31
C22orf32-0.25-0.29
COX6A1-0.25-0.25
C19orf53-0.25-0.28
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006508proteolysisTAS7797510 
GO:0006917induction of apoptosisTAS7743998 
GO:0042981regulation of apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APAF1CED4 | DKFZp781B1145apoptotic peptidase activating factor 1-HPRD,BioGRID9539746 
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD15123740 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)Reconstituted ComplexBioGRID10477277 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP14MGC119078 | MGC119079caspase 14, apoptosis-related cysteine peptidase-HPRD,BioGRID9792675 
CASP4ICE(rel)II | ICEREL-II | ICH-2 | Mih1/TX | TXcaspase 4, apoptosis-related cysteine peptidase-HPRD,BioGRID10872455 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8962078 
CDK2p33(CDK2)cyclin-dependent kinase 2Affinity Capture-MSBioGRID17353931 
CTNNBIP1ICAT | MGC15093catenin, beta interacting protein 1Affinity Capture-MSBioGRID17353931 
DSPDPI | DPIIdesmoplakin-HPRD15500642 
EIF2S3EIF2 | EIF2G | EIF2gamma | eIF-2gAeukaryotic translation initiation factor 2, subunit 3 gamma, 52kDaAffinity Capture-MSBioGRID17353931 
GCN1L1GCN1 | GCN1L | KIAA0219GCN1 general control of amino-acid synthesis 1-like 1 (yeast)Affinity Capture-MSBioGRID17353931 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)Affinity Capture-MSBioGRID17353931 
HEATR2FLJ20397 | FLJ25564 | FLJ31671 | FLJ39381HEAT repeat containing 2Affinity Capture-MSBioGRID17353931 
IL18IGIF | IL-18 | IL-1g | IL1F4 | MGC12320interleukin 18 (interferon-gamma-inducing factor)Biochemical ActivityBioGRID12096920 
IL1F7FIL1 | FIL1(ZETA) | FIL1Z | IL-1F7 | IL-1H4 | IL-1RP1 | IL1H4 | IL1RP1interleukin 1 family, member 7 (zeta)Biochemical ActivityBioGRID12096920 
KIAA0776RP3-393D12.1KIAA0776Affinity Capture-MSBioGRID17353931 
MSH6GTBP | HNPCC5 | HSAPmutS homolog 6 (E. coli)Affinity Capture-MSBioGRID17353931 
MTHFD1LDKFZp586G1517 | FLJ21145 | FTHFSDC1 | MTC1THFS | dJ292B18.2methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-likeAffinity Capture-MSBioGRID17353931 
MYCBPAPAMAP-1 | AMAP1 | DKFZp434N1415MYCBP associated proteinAffinity Capture-MSBioGRID17353931 
NOD1CARD4 | CLR7.1 | NLRC1nucleotide-binding oligomerization domain containing 1-HPRD,BioGRID10329646 
NUP93KIAA0095 | MGC21106nucleoporin 93kDaAffinity Capture-MSBioGRID17353931 
PSEN1AD3 | FAD | PS1 | S182presenilin 1PS1 interacts with caspase 4. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 4.BIND10069390 
PSMB1FLJ25321 | HC5 | KIAA1838 | PMSB1 | PSC5proteasome (prosome, macropain) subunit, beta type, 1Affinity Capture-MSBioGRID17353931 
SERPINB9CAP-3 | CAP3 | PI9serpin peptidase inhibitor, clade B (ovalbumin), member 9-HPRD10477277 
SLC25A22FLJ13044 | GC1solute carrier family 25 (mitochondrial carrier: glutamate), member 22Affinity Capture-MSBioGRID17353931 
SMC1ACDLS2 | DKFZp686L19178 | DXS423E | KIAA0178 | MGC138332 | SB1.8 | SMC1 | SMC1L1 | SMC1alpha | SMCBstructural maintenance of chromosomes 1AAffinity Capture-MSBioGRID17353931 
SMC2CAP-E | CAPE | FLJ10093 | SMC2L1 | hCAP-Estructural maintenance of chromosomes 2Affinity Capture-MSBioGRID17353931 
SMC3BAM | BMH | CDLS3 | CSPG6 | HCAP | SMC3L1structural maintenance of chromosomes 3Affinity Capture-MSBioGRID17353931 
SRPRBAPMCF1signal recognition particle receptor, B subunitAffinity Capture-MSBioGRID17353931 
USP9XDFFRX | FAF | FAMubiquitin specific peptidase 9, X-linkedAffinity Capture-MSBioGRID17353931 
VDAC3HD-VDAC3voltage-dependent anion channel 3Affinity Capture-MSBioGRID17353931 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosisAffinity Capture-WesternBioGRID11927604 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_CASPASE_PATHWAY 2315All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_NOD1_2_SIGNALING_PATHWAY 3022All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 4633All SZGR genes in this pathway
WATANABE_RECTAL_CANCER_RADIOTHERAPY_RESPONSIVE_DN 9251All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN 320184All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_20Q13_AMPLIFICATION_DN 180101All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_DN 209122All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_DN 229142All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_UP 215137All SZGR genes in this pathway
MANN_RESPONSE_TO_AMIFOSTINE_UP 2012All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
MANTOVANI_NFKB_TARGETS_UP 4333All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_UP 6235All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
WU_HBX_TARGETS_3_UP 1811All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
ZHANG_PROLIFERATING_VS_QUIESCENT 5141All SZGR genes in this pathway
GAJATE_RESPONSE_TO_TRABECTEDIN_UP 6745All SZGR genes in this pathway
WU_HBX_TARGETS_1_UP 1610All SZGR genes in this pathway
SAFFORD_T_LYMPHOCYTE_ANERGY 8754All SZGR genes in this pathway
WU_HBX_TARGETS_2_UP 2313All SZGR genes in this pathway
HARRIS_BRAIN_CANCER_PROGENITORS 4423All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P2 7955All SZGR genes in this pathway
GALI_TP53_TARGETS_APOPTOTIC_UP 87All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_UP 245159All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
SEKI_INFLAMMATORY_RESPONSE_LPS_UP 7756All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
MIKKELSEN_MEF_LCP_WITH_H3K4ME3 12868All SZGR genes in this pathway
ONO_AML1_TARGETS_DN 4125All SZGR genes in this pathway
ONO_FOXP3_TARGETS_DN 4223All SZGR genes in this pathway
KESHELAVA_MULTIPLE_DRUG_RESISTANCE 8856All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN 6845All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_UP 8363All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_DN 210141All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_LB_DN 4423All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_0 7654All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_DN 8766All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
KIM_GLIS2_TARGETS_UP 8461All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_UP 682433All SZGR genes in this pathway
ALTEMEIER_RESPONSE_TO_LPS_WITH_MECHANICAL_VENTILATION 12881All SZGR genes in this pathway


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