Gene Page: CASP6

Summary
GeneID  839
Symbol  CASP6
Synonyms  MCH2
Description  caspase 6, apoptosis-related cysteine peptidase
See related  HGNC:1507|MIM:601532|Ensembl:ENSG00000138794|HPRD:03321|
Locus tag  -
Gene type  protein-coding
Map location  4q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0235 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MDS10.680.64
EVI10.680.63
CXorf360.670.67
GIMAP80.650.62
A2M0.650.64
COBLL10.640.63
FLI10.640.60
SLCO2B10.640.65
CDH50.630.64
TGFBR20.630.62
Top 10 negatively co-expressed genes
C12orf45-0.43-0.47
RPL31-0.42-0.46
RPL27-0.41-0.50
RPS20-0.40-0.48
SNRPD2-0.39-0.43
RPL34-0.39-0.44
NDUFAF2-0.39-0.42
PFDN2-0.39-0.39
RPS25P8-0.38-0.44
FAM128B-0.38-0.44
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12888622 
GO:0004197cysteine-type endopeptidase activityIEA-
GO:0008233peptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIDA12888622 
GO:0006917induction of apoptosisTAS7796396 
GO:0006915apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BIRC6APOLLON | BRUCE | FLJ13726 | FLJ13786 | KIAA1289baculoviral IAP repeat-containing 6BRUCE interacts with Casp-6. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-6.BIND15200957 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD,BioGRID8962078 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID8900201 
CASP6MCH2caspase 6, apoptosis-related cysteine peptidaseBiochemical ActivityBioGRID12232792 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID12232792 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3Two-hybridBioGRID16169070 
DSPDPI | DPIIdesmoplakin-HPRD15500642 
HSPD1CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13heat shock 60kDa protein 1 (chaperonin)-HPRD,BioGRID10205159 
HTTHD | IT15huntingtinHtt interacts with caspase 6.BIND14713958 
LMNB1ADLD | LMN | LMN2 | LMNB | MGC111419lamin B1-HPRD11901153 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1CASP6 (caspase-6) cleaves RB-1 (hRB) at the DSID consensus site to produce the p68 form.BIND15735701 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1Biochemical ActivityBioGRID11098060 
XIAPAPI3 | BIRC4 | ILP1 | MIHA | XLP2X-linked inhibitor of apoptosisXIAP interacts with Casp-6.BIND15200957 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
BIOCARTA_CHEMICAL_PATHWAY 2215All SZGR genes in this pathway
BIOCARTA_CASPASE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_FAS_PATHWAY 3022All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_DEATH_PATHWAY 3324All SZGR genes in this pathway
BIOCARTA_MITOCHONDRIA_PATHWAY 2115All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS 4026All SZGR genes in this pathway
REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS 1311All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN 6642All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
LIU_CMYB_TARGETS_UP 165106All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN 8454All SZGR genes in this pathway
LANG_MYB_FAMILY_TARGETS 2916All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP 2920All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
JIANG_AGING_CEREBRAL_CORTEX_UP 3627All SZGR genes in this pathway
MURAKAMI_UV_RESPONSE_6HR_UP 3731All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
JI_RESPONSE_TO_FSH_UP 7456All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_6HR_DN 160101All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_UP 4731All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
OUILLETTE_CLL_13Q14_DELETION_DN 6038All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN 4934All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_LATE_RECURRENCE_DN 6948All SZGR genes in this pathway
RAMPON_ENRICHED_LEARNING_ENVIRONMENT_EARLY_DN 1010All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_MIDDLE 9856All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GUO_TARGETS_OF_IRS1_AND_IRS2 9867All SZGR genes in this pathway


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