Gene Page: ADAM15

Summary
GeneID  8751
Symbol  ADAM15
Synonyms  MDC15
Description  ADAM metallopeptidase domain 15
See related  HGNC:193|MIM:605548|Ensembl:ENSG00000143537|HPRD:05674|
Locus tag  RP11-540D14.1
Gene type  protein-coding
Map location  1q21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FZD10.680.72
TNFRSF10B0.660.55
TNFRSF190.660.73
FZD70.640.65
SNCAIP0.640.70
COL5A10.640.50
ADAMTS30.640.69
SALL20.640.79
ATP7B0.640.78
CTNND10.630.78
Top 10 negatively co-expressed genes
C5orf53-0.42-0.61
AF347015.31-0.41-0.69
MT-CO2-0.41-0.70
AF347015.33-0.39-0.63
AF347015.27-0.39-0.64
FXYD1-0.39-0.63
CXCL14-0.39-0.66
IFI27-0.39-0.64
HIGD1B-0.38-0.67
AF347015.8-0.38-0.66
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI10531379 
GO:0004222metalloendopeptidase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0017124SH3 domain bindingIPI10531379 
GO:0008233peptidase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007160cell-matrix adhesionTAS9516430 
GO:0007155cell adhesionNAS10531379 
GO:0006508proteolysisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0016021integral to membraneNAS10531379 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD11741929 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID11741929 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID11741929 
HCKJTK9hemopoietic cell kinase-HPRD,BioGRID11741929 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID11741929 
MAD2L1HSMAD2 | MAD2MAD2 mitotic arrest deficient-like 1 (yeast)Affinity Capture-WesternBioGRID11741929 
MAD2L2MAD2B | REV7MAD2 mitotic arrest deficient-like 2 (yeast)Two-hybridBioGRID10527948 
SH3D19EBP | EVE1 | Kryn | MGC105136 | MGC118910 | MGC118911 | MGC118912 | MGC118913 | SH3P19SH3 domain containing 19An unspecified isoform of ADAM15 binds to Eve-1c.BIND15280379 
An unspecified isoform of ADAM9 binds to Eve-1d.BIND15280379 
-HPRD15280379 
SH3GL2CNSA2 | EEN-B1 | FLJ20276 | FLJ25015 | SH3D2A | SH3P4SH3-domain GRB2-like 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10531379 
SNX9MST155 | MSTP155 | SDP1 | SH3PX1 | SH3PXD3A | WISPsorting nexin 9-HPRD,BioGRID10531379 
SPAG5DEEPEST | MAP126 | hMAP126sperm associated antigen 5-HPRD10531379 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD11741929 
TRIP1316E1BPthyroid hormone receptor interactor 13Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_INTEGRIN_A9B1_PATHWAY 2518All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_1Q21_AMPLICON 3818All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 8758All SZGR genes in this pathway
KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP 5129All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_UP 4426All SZGR genes in this pathway
AFFAR_YY1_TARGETS_UP 214133All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP 317208All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP 221150All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
KESHELAVA_MULTIPLE_DRUG_RESISTANCE 8856All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_16 7947All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_UP 11573All SZGR genes in this pathway
NABA_ECM_REGULATORS 238125All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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