Gene Page: NRP1

Summary
GeneID  8829
Symbol  NRP1
Synonyms  BDCA4|CD304|DKFZp686A03134|DKFZp781F1414|NP1|NRP|VEGF165R
Description  neuropilin 1
See related  HGNC:8004|MIM:602069|Ensembl:ENSG00000099250|HPRD:03642|
Locus tag  RP11-342D11.1
Gene type  protein-coding
Map location  10p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZCCHC120.750.73
SLC26A110.730.77
CPNE20.730.74
NSUN70.730.66
GDPD20.710.62
DCLK20.710.73
TPST10.700.71
CCNA10.700.71
CTNNB10.700.66
ANUBL10.700.66
Top 10 negatively co-expressed genes
MT-CO2-0.46-0.52
AF347015.21-0.45-0.52
AF347015.27-0.44-0.50
AF347015.31-0.44-0.49
AF347015.8-0.43-0.49
AF347015.33-0.42-0.46
AF347015.2-0.42-0.50
MT-CYB-0.42-0.46
AF347015.15-0.40-0.46
MT-ATP8-0.39-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005021vascular endothelial growth factor receptor activityTAS9288753 
GO:0004872receptor activityIEA-
GO:0042802identical protein bindingIEA-
GO:0017154semaphorin receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007413axonal fasciculationIEAneuron, axon (GO term level: 13)-
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0007411axon guidanceTASaxon (GO term level: 13)9288753 
GO:0030517negative regulation of axon extensionIEAaxon (GO term level: 15)-
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0001569patterning of blood vesselsIEA-
GO:0007155cell adhesionIEA-
GO:0007267cell-cell signalingTAS9288753 
GO:0009887organ morphogenesisTAS9529250 
GO:0007165signal transductionTAS9288753 
GO:0008284positive regulation of cell proliferationTAS9529250 
GO:0007507heart developmentIEA-
GO:0048010vascular endothelial growth factor receptor signaling pathwayIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FGF1AFGF | ECGF | ECGF-beta | ECGFA | ECGFB | FGF-alpha | FGFA | GLIO703 | HBGF1fibroblast growth factor 1 (acidic)NRP1 (Npn-1) interacts with FGF1. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF1.BIND15695515 
FGF2BFGF | FGFB | HBGF-2fibroblast growth factor 2 (basic)NRP1 (Npn-1) interacts with FGF2. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF2.BIND15695515 
FGF4HBGF-4 | HST | HST-1 | HSTF1 | K-FGF | KFGFfibroblast growth factor 4NRP1 (Npn-1) interacts with FGF4. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF4.BIND15695515 
FGF7HBGF-7 | KGFfibroblast growth factor 7 (keratinocyte growth factor)NRP1 (Npn-1) interacts with FGF7. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF7.BIND15695515 
HGFF-TCF | HGFB | HPTA | SFhepatocyte growth factor (hepapoietin A; scatter factor)NRP1 (Npn-1) interacts with HGF. This interaction was modeled on a demonstrated interaction between rat NRP1 and human HGF.BIND15695515 
PGFD12S1900 | PGFL | PLGF | PlGF-2 | SHGC-10760placental growth factorNRP1 interacts with PlGF-2. This interaction was modeled on a demonstrated interaction between human NRP1 and mouse PlGF-2.BIND11986311 
-HPRD,BioGRID11986311 
PLXNA1NOV | NOVP | PLEXIN-A1 | PLXN1plexin A1-HPRD10520994 
PLXND1KIAA0620 | MGC75353 | PLEXD1plexin D1PlexinD1 interacts with Npn-1. This interaction was modeled on a demonstrated interaction between human PlexinD1 and Npn-1 from an unspecified species.BIND15239958 
SEMA3AHsema-I | Hsema-III | MGC133243 | SEMA1 | SEMAD | SEMAIII | SEMAL | SemD | coll-1sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A-HPRD,BioGRID9331348 |10520994 
Sema3A interacts with Npn-1. This interaction was modeled on a demonstrated interaction between human Sema3A and rat Npn-1.BIND15550623 
SEMA3BFLJ34863 | LUCA-1 | SEMA5 | SEMAA | SemA | semaVsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B-HPRD10196546 
SEMA3FSEMA-IV | SEMA4 | SEMAKsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F-HPRD9883722 
VEGFAMGC70609 | VEGF | VEGF-A | VPFvascular endothelial growth factor AAffinity Capture-Western
Reconstituted Complex		BioGRID9529250 |11986311 
NRP1 interacts with VEGF165.BIND11986311 
-HPRD9529250 |10409677 
|11986311 
VEGF165 interacts with neuropilin-1. This interaction was modeled on a demonstrated interaction between human VEGF165 and neuropilin-1 from an unspecified species.BIND14600159 
VEGFBVEGFL | VRFvascular endothelial growth factor B-HPRD,BioGRID10409677 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
PID_VEGF_VEGFR_PATHWAY 106All SZGR genes in this pathway
PID_VEGFR1_PATHWAY 2623All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS 106All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_CRMPS_IN_SEMA3A_SIGNALING 1414All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 1514All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION 139All SZGR genes in this pathway
REACTOME_L1CAM_INTERACTIONS 8662All SZGR genes in this pathway
REACTOME_SIGNAL_TRANSDUCTION_BY_L1 3425All SZGR genes in this pathway
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP 351230All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN 455304All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
ROY_WOUND_BLOOD_VESSEL_UP 5030All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_DN 205127All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_DN 14290All SZGR genes in this pathway
KIM_WT1_TARGETS_DN 459276All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
LANDIS_BREAST_CANCER_PROGRESSION_DN 7043All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
BERENJENO_ROCK_SIGNALING_NOT_VIA_RHOA_DN 4834All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_65_DN 3722All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_DN 14993All SZGR genes in this pathway
WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN 10166All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
LIAO_HAVE_SOX4_BINDING_SITES 4026All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
GUENTHER_GROWTH_SPHERICAL_VS_ADHERENT_DN 2619All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_UP 256159All SZGR genes in this pathway
ROSS_AML_WITH_CBFB_MYH11_FUSION 5232All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
GUO_HEX_TARGETS_UP 8154All SZGR genes in this pathway
ABBUD_LIF_SIGNALING_2_UP 1413All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_DN 4531All SZGR genes in this pathway
GERY_CEBP_TARGETS 12690All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
PETROVA_PROX1_TARGETS_DN 6438All SZGR genes in this pathway
REN_ALVEOLAR_RHABDOMYOSARCOMA_DN 408274All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
HU_GENOTOXIN_ACTION_DIRECT_VS_INDIRECT_4HR 3722All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_DN 8662All SZGR genes in this pathway
RAMALHO_STEMNESS_DN 7455All SZGR genes in this pathway
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_DN 4232All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_DN 5739All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
MODY_HIPPOCAMPUS_NEONATAL 3525All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
HENDRICKS_SMARCA4_TARGETS_DN 5334All SZGR genes in this pathway
TSENG_IRS1_TARGETS_DN 13588All SZGR genes in this pathway
TSENG_ADIPOGENIC_POTENTIAL_DN 4628All SZGR genes in this pathway
MCDOWELL_ACUTE_LUNG_INJURY_DN 4833All SZGR genes in this pathway
BILD_MYC_ONCOGENIC_SIGNATURE 206117All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T4 9469All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P4 10062All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_UP 2616All SZGR genes in this pathway
KONDO_EZH2_TARGETS 245148All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
LE_SKI_TARGETS_UP 1712All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_UP 11271All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_DN 4022All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
VALK_AML_CLUSTER_9 3526All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
ZEMBUTSU_SENSITIVITY_TO_CYCLOPHOSPHAMIDE 1812All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT 567365All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BHAT_ESR1_TARGETS_VIA_AKT1_DN 8251All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_DN 229135All SZGR genes in this pathway
BAKKER_FOXO3_TARGETS_DN 187109All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
DELACROIX_RAR_TARGETS_DN 2416All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206253725441A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-124.1244124471Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506748754m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/30121342140m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1375715781A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-141/200a219221991A,m8hsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-142-5p11661172m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-148/152213521421A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-186226722731Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-194219522011Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-21411361142m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-30-5p563569m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-320112711341A,m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-324-3p21902196m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-326199119981A,m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-338353359m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-361213921451Ahsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-37623912397m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-3819789841Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-494242024261Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-5391221281Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-9254225481Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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