Gene Page: BCL10

Summary
GeneID  8915
Symbol  BCL10
Synonyms  CARMEN|CIPER|CLAP|c-E10|mE10
Description  B-cell CLL/lymphoma 10
See related  HGNC:989|MIM:603517|Ensembl:ENSG00000142867|HPRD:04625|
Locus tag  -
Gene type  protein-coding
Map location  1p22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003713transcription coactivator activityIDA15207693 
GO:0008022protein C-terminus bindingIPI11053425 
GO:0031625ubiquitin protein ligase bindingIPI16395405 
GO:0051059NF-kappaB bindingIDA16280327 
GO:0019209kinase activator activityIDA15125833 
GO:0043130ubiquitin bindingIDA15082780 
GO:0043422protein kinase B bindingIPI16280327 
GO:0043621protein self-associationIPI15125833 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002237response to molecule of bacterial originIEP16831874 
GO:0002250adaptive immune responseTAS16831874 
GO:0002906negative regulation of mature B cell apoptosisIDA15878976 
GO:0002224toll-like receptor signaling pathwayIC16831874 
GO:0001843neural tube closureISS11163238 
GO:0016064immunoglobulin mediated immune responseIEA-
GO:0008219cell deathIDA10400625 
GO:0006968cellular defense responseIEA-
GO:0009620response to fungusIEA-
GO:0042981regulation of apoptosisIEA-
GO:0042226interleukin-6 biosynthetic processNAS16647297 
GO:0042327positive regulation of phosphorylationIDA15125833 
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA10400625 |14695475 
GO:0042109lymphotoxin A biosynthetic processNAS16647297 
GO:0050870positive regulation of T cell activationIEA-
GO:0050856regulation of T cell receptor signaling pathwayIEA-
GO:0031398positive regulation of protein ubiquitinationIDA14695475 
GO:0032765positive regulation of mast cell cytokine productionNAS16647297 
GO:0051260protein homooligomerizationISS16831874 
GO:0051260protein homooligomerizationTAS16831874 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045893positive regulation of transcription, DNA-dependentIDA15207693 
GO:0045087innate immune responseIEP16831874 
GO:0045786negative regulation of cell cycleIEA-
GO:0045416positive regulation of interleukin-8 biosynthetic processIMP17095757 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042101T cell receptor complexIDASynap (GO term level: 8)12154360 
GO:0005829cytosolEXP15122200 |15125833 |17468049 
GO:0005829cytosolIDA12154360 
GO:0005622intracellularIEA-
GO:0005634nucleusIDA16280327 
GO:0005737cytoplasmIDA11021819 |11053425 |11278692 
|15082780 
GO:0005764lysosomeIDA15082780 
GO:0048471perinuclear region of cytoplasmIDA16127295 
GO:0032449CBM complexNAS15125833 
GO:0045121membrane raftIEA-
GO:0046696lipopolysaccharide receptor complexIDA16831874 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL10CARMEN | CIPER | CLAP | c-E10 | mE10B-cell CLL/lymphoma 10Bcl10 interacts with itself.BIND15125833 
C9orf89BinCARD | MGC110898 | MGC11115 | bA370F5.1chromosome 9 open reading frame 89-HPRD,BioGRID15637807 
CARD10BIMP1 | CARMA3 | MGC142219caspase recruitment domain family, member 10-HPRD,BioGRID11259443 |11387339 
CARD10 interacts with BCL10.BIND11259443 
CARD11BIMP3 | CARMA1 | MGC133069caspase recruitment domain family, member 11-HPRD,BioGRID11278692 
CARD11 interacts with BCL10.BIND11278692 
CARD14BIMP2 | CARMA2caspase recruitment domain family, member 14-HPRD,BioGRID11278692 
CARD14 interacts with BCL10.BIND11278692 
CARD9hCARD9caspase recruitment domain family, member 9-HPRD,BioGRID11053425 
CARD9 interacts with BCL10.BIND11053425 
CASP9APAF-3 | APAF3 | CASPASE-9c | ICE-LAP6 | MCH6caspase 9, apoptosis-related cysteine peptidase-HPRD10187815 
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinase-HPRD11113112 
HIST1H2BCH2B.1 | H2B/l | H2BFL | MGC104246 | dJ221C16.3histone cluster 1, H2bcAffinity Capture-MSBioGRID17353931 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaBcl10 interacts with NEMO.BIND14695475 
KRT33BHA3II | Ha-3II | KRTHA3A | KRTHA3B | hHa3-IIkeratin 33BAffinity Capture-MSBioGRID17353931 
MALT1DKFZp434L132 | MLT | MLT1mucosa associated lymphoid tissue lymphoma translocation gene 1-HPRD,BioGRID11090634 
Bcl10 interacts with paracaspase.BIND14695475 
NLRC4CARD12 | CLAN | CLAN1 | CLANA | CLANB | CLANC | CLAND | CLR2.1 | IPAFNLR family, CARD domain containing 4-HPRD,BioGRID11472070 
CARD12 (CLAN) interacts with Bcl10. This interaction was modelled on a demonstrated interaction between human CARD12 and Bcl10 from an unspecified species.BIND11472070 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10a-HPRD,BioGRID10400625 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ATwo-hybridBioGRID10400625 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD,BioGRID10400625 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID10753917 
UBE2NMGC131857 | MGC8489 | UBC13 | UbcH-benubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)Bcl10 interacts with UBC13.BIND14695475 
UBE2V2DDVIT1 | DDVit-1 | EDAF-1 | EDPF-1 | EDPF1 | MMS2 | UEV-2 | UEV2ubiquitin-conjugating enzyme E2 variant 2Bcl10 interacts with MMS2.BIND14695475 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 7556All SZGR genes in this pathway
SA_PROGRAMMED_CELL_DEATH 129All SZGR genes in this pathway
PID_BCR_5PATHWAY 6550All SZGR genes in this pathway
PID_TCR_PATHWAY 6651All SZGR genes in this pathway
PID_NFKAPPAB_CANONICAL_PATHWAY 2320All SZGR genes in this pathway
PID_CD8_TCR_PATHWAY 5342All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 6443All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_TCR_SIGNALING 5446All SZGR genes in this pathway
REACTOME_DOWNSTREAM_TCR_SIGNALING 3732All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN 13686All SZGR genes in this pathway
LIU_SOX4_TARGETS_UP 13794All SZGR genes in this pathway
BILBAN_B_CLL_LPL_UP 6339All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
NAGASHIMA_EGF_SIGNALING_UP 5840All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
SCHEIDEREIT_IKK_TARGETS 1815All SZGR genes in this pathway
HUMMERICH_SKIN_CANCER_PROGRESSION_UP 8858All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_2 12792All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_DN 156106All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_HELA 6947All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_MCF10A 4328All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_VS_CD2_DN 5235All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
ZHANG_RESPONSE_TO_CANTHARIDIN_UP 1912All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_UP 1813All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
TAYLOR_METHYLATED_IN_ACUTE_LYMPHOBLASTIC_LEUKEMIA 7752All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_PR_DN 4434All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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