Gene Page: CCNE1

Summary
GeneID  898
Symbol  CCNE1
Synonyms  CCNE
Description  cyclin E1
See related  HGNC:1589|MIM:123837|Ensembl:ENSG00000105173|HPRD:00455|
Locus tag  -
Gene type  protein-coding
Map location  19q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.004 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003713transcription coactivator activityNAS15572661 
GO:0005515protein bindingIPI9891079 
GO:0050681androgen receptor bindingNAS15572661 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleNAS8207080 
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
GO:0030521androgen receptor signaling pathwayNAS15572661 
GO:0045893positive regulation of transcription, DNA-dependentNAS15572661 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP7799941 |11907280 
GO:0005634nucleusNAS-
GO:0005654nucleoplasmEXP7629134 |10454565 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID10953010 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-WesternBioGRID17525332 
CABLES1CABLES | FLJ35924 | HsT2563 | IK3-1Cdk5 and Abl enzyme substrate 1-HPRD11733001 
CCT4CCT-DELTA | Cctd | MGC126164 | MGC126165 | SRBchaperonin containing TCP1, subunit 4 (delta)-HPRD,BioGRID9819444 
CDC2CDC28A | CDK1 | DKFZp686L20222 | MGC111195cell division cycle 2, G1 to S and G2 to M-HPRD,BioGRID1388288 
CDC25ACDC25A2cell division cycle 25 homolog A (S. pombe)-HPRD,BioGRID8617791 
CDK2p33(CDK2)cyclin-dependent kinase 2-HPRD,BioGRID1388288 
CDK3-cyclin-dependent kinase 3-HPRD,BioGRID11733001 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)p21 interacts with cyclin E.BIND9632134 
Affinity Capture-WesternBioGRID12839982 
CDKN1A (p21) interacts with CCNE1 (cyclin E).BIND8662825 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)p27 interacts with cyclin E.BIND9632134 
p27 interacts with Cyc E.BIND15469821 
Affinity Capture-WesternBioGRID9891079 |12529437 
COILCLN80 | p80-coilincoilin-HPRD,BioGRID10751146 
CUL3-cullin 3-HPRD,BioGRID10500095 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingAffinity Capture-WesternBioGRID9891079 
FBXW7AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10F-box and WD repeat domain containing 7Phosphorylated cycE interacts with Fbw7. This interaction was modeled on a demonstrated interaction between cycE from human and Fbw7 from an unspecified species.BIND14739463 
-HPRD,BioGRID11533444 |11565033 
|14536078 
hCDC4 interacts with cyclin E. This interaction was modelled on a demonstrated interaction between human CDC4 and cyclin E from an unspecified species.BIND14999283 
GSK3B-glycogen synthase kinase 3 betaBiochemical ActivityBioGRID14536078 
HERC5CEB1 | CEBP1hect domain and RLD 5-HPRD,BioGRID10581175 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkinAffinity Capture-WesternBioGRID12628165 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)-HPRD8230483 
Affinity Capture-WesternBioGRID9891079 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)-HPRD,BioGRID8253383 
RELC-Relv-rel reticuloendotheliosis viral oncogene homolog (avian)-HPRD9731206 
RRN3DKFZp566E104 | MGC104238 | TIFIARRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)Reconstituted ComplexBioGRID15004009 
SF3B1PRP10 | PRPF10 | SAP155 | SF3b155splicing factor 3b, subunit 1, 155kDaAffinity Capture-WesternBioGRID9891079 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)-HPRD,BioGRID11237742 
SMARCA2BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Affinity Capture-WesternBioGRID9891079 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID9891079 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-WesternBioGRID9891079 
SMARCC1BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1-HPRD,BioGRID9891079 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CELL_CYCLE 12884All SZGR genes in this pathway
KEGG_OOCYTE_MEIOSIS 11479All SZGR genes in this pathway
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_PROSTATE_CANCER 8975All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
BIOCARTA_MCM_PATHWAY 188All SZGR genes in this pathway
BIOCARTA_G1_PATHWAY 2821All SZGR genes in this pathway
BIOCARTA_CELLCYCLE_PATHWAY 2315All SZGR genes in this pathway
BIOCARTA_SKP2E2F_PATHWAY 106All SZGR genes in this pathway
BIOCARTA_RACCYCD_PATHWAY 2623All SZGR genes in this pathway
BIOCARTA_P53_PATHWAY 1613All SZGR genes in this pathway
BIOCARTA_P27_PATHWAY 1310All SZGR genes in this pathway
SA_REG_CASCADE_OF_CYCLIN_EXPR 137All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_FOXM1_PATHWAY 4030All SZGR genes in this pathway
PID_BARD1_PATHWAY 2919All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
REACTOME_G0_AND_EARLY_G1 2513All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_CELL_CYCLE_CHECKPOINTS 12470All SZGR genes in this pathway
REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 6540All SZGR genes in this pathway
REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 5735All SZGR genes in this pathway
REACTOME_G1_S_TRANSITION 11263All SZGR genes in this pathway
REACTOME_MITOTIC_G1_G1_S_PHASES 13779All SZGR genes in this pathway
REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 3517All SZGR genes in this pathway
REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 199All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 5634All SZGR genes in this pathway
VECCHI_GASTRIC_CANCER_EARLY_UP 430232All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
GRAHAM_CML_DIVIDING_VS_NORMAL_QUIESCENT_UP 181101All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_DN 8749All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_1_DN 378231All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_3_UP 329196All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
OUELLET_CULTURED_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 6940All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_UP 2920All SZGR genes in this pathway
MARKS_HDAC_TARGETS_UP 2315All SZGR genes in this pathway
KONG_E2F3_TARGETS 9758All SZGR genes in this pathway
BAKER_HEMATOPOESIS_STAT5_TARGETS 77All SZGR genes in this pathway
LI_LUNG_CANCER 4130All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
HONRADO_BREAST_CANCER_BRCA1_VS_BRCA2 1812All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
OXFORD_RALA_OR_RALB_TARGETS_UP 4823All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_UP 10869All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN 6638All SZGR genes in this pathway
PUJANA_BREAST_CANCER_LIT_INT_NETWORK 10173All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN 6441All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
FUJIWARA_PARK2_IN_LIVER_CANCER_UP 87All SZGR genes in this pathway
GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN 176104All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
STANELLE_E2F1_TARGETS 2920All SZGR genes in this pathway
KANNAN_TP53_TARGETS_DN 2115All SZGR genes in this pathway
PEART_HDAC_PROLIFERATION_CLUSTER_UP 5735All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
TENEDINI_MEGAKARYOCYTE_MARKERS 6648All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_DN 5132All SZGR genes in this pathway
NUMATA_CSF3_SIGNALING_VIA_STAT3 2217All SZGR genes in this pathway
VERNELL_RETINOBLASTOMA_PATHWAY_UP 7047All SZGR genes in this pathway
ZAMORA_NOS2_TARGETS_UP 6941All SZGR genes in this pathway
GENTILE_UV_LOW_DOSE_UP 2719All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_8HR_UP 10573All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_UP 180125All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
SONG_TARGETS_OF_IE86_CMV_PROTEIN 6042All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN 287208All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_DN 318220All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
WANG_LSD1_TARGETS_UP 2414All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
MARZEC_IL2_SIGNALING_UP 11580All SZGR genes in this pathway
OUYANG_PROSTATE_CANCER_MARKERS 1916All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_DN 187All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_UP 648398All SZGR genes in this pathway
BONCI_TARGETS_OF_MIR15A_AND_MIR16_1 9175All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
PODAR_RESPONSE_TO_ADAPHOSTIN_DN 1816All SZGR genes in this pathway
LU_TUMOR_ANGIOGENESIS_UP 2522All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
RUIZ_TNC_TARGETS_DN 14279All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
ISHIDA_E2F_TARGETS 5327All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_UP 178108All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP 7543All SZGR genes in this pathway
FONTAINE_PAPILLARY_THYROID_CARCINOMA_UP 6638All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_LITERATURE 4425All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_G1_S 14776All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_UP 8451All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-138211217m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-15/16/195/424/4972472541A,m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-26265271m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-5034864921Ahsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-918251A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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