Gene Page: CCNT1

Summary
GeneID  904
Symbol  CCNT1
Synonyms  CCNT|CYCT1
Description  cyclin T1
See related  HGNC:1599|MIM:602506|Ensembl:ENSG00000129315|HPRD:03938|
Locus tag  -
Gene type  protein-coding
Map location  12pter-qter
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.606 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIDA16109376 
GO:0005515protein bindingIPI12944466 
GO:0017069snRNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000079regulation of cyclin-dependent protein kinase activityTAS9499409 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006468protein amino acid phosphorylationIPI16109376 
GO:0006366transcription from RNA polymerase II promoterTAS9499409 
GO:0007049cell cycleIEA-
GO:0051301cell divisionIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12944466 
GO:0005654nucleoplasmEXP7853496 |12676794 
GO:0005730nucleolusIDA16109376 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AFF4AF5Q31 | MCEF | MGC75036AF4/FMR2 family, member 4-HPRD,BioGRID12065898 
AHR-aryl hydrocarbon receptor-HPRD,BioGRID12917420 
CCNKCPR4 | MGC9113cyclin Kin vitro
in vivo		BioGRID10574912 
CDK9C-2k | CDC2L4 | CTK1 | PITALRE | TAKcyclin-dependent kinase 9-HPRD9872325 |10465067 
|10617616 |11145967 
|11689688 |11713532 
|11713533 |12115727 
|12894230 |14627702 
|15528190 
CyclinT1 interacts with Cdk9.BIND9499409 
CycT1 interacts with CDK9. This interaction was modeled on a demonstrated interaction between CycT1 from an unspecified species and human CDK9.BIND15546612 
Affinity Capture-Western
in vitro
in vivo
Phenotypic Suppression
Reconstituted Complex
Two-hybrid		BioGRID9499409 |10656684 
|10958691 |11689688 
|12588988 |12832472 
|12944466 |15107825 
Cyclin T1 interacts with CDK9.BIND12588988 
-HPRD9499409 |10958691 
GRIPAP1DKFZp434P0630 | GRASP-1 | KIAA1167 | MGC126593 | MGC126595GRIP1 associated protein 1in vitro
in vivo		BioGRID11704662 
GRNGEP | GP88 | PCDGF | PEPI | PGRNgranulin-HPRD,BioGRID12588988 
Cyclin T1 interacts with granulin.BIND12588988 
HEXIM1CLP1 | EDG1 | FLJ13562 | HIS1 | MAQ1hexamethylene bis-acetamide inducible 1-HPRD,BioGRID12832472 
HTATSF1TAT-SF1 | dJ196E23.2HIV-1 Tat specific factor 1-HPRD,BioGRID10913173 |11780068 
MDFICHICMyoD family inhibitor domain containingAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID12944466 
MYBL2B-MYB | BMYB | MGC15600v-myb myeloblastosis viral oncogene homolog (avian)-like 2Phenotypic SuppressionBioGRID10656684 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)-HPRD,BioGRID12944920 
NCOA2GRIP1 | KAT13C | MGC138808 | NCoA-2 | TIF2nuclear receptor coactivator 2Cyclin T1 interacts with GRIP1.BIND11704662 
NUFIP1NUFIP | bA540M5.1nuclear fragile X mental retardation protein interacting protein 1Affinity Capture-Western
Reconstituted Complex		BioGRID15107825 
CyclinT1 interacts with NUFIP.BIND15107825 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID12727882 
PURAPUR-ALPHA | PUR1 | PURALPHApurine-rich element binding protein A-HPRD,BioGRID11730934 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)-HPRD11689688 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION 2717All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER 3826All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
REACTOME_RNA_POL_II_TRANSCRIPTION 10554All SZGR genes in this pathway
REACTOME_TRANSCRIPTION 210127All SZGR genes in this pathway
REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 4519All SZGR genes in this pathway
REACTOME_ELONGATION_ARREST_AND_RECOVERY 3214All SZGR genes in this pathway
REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 6132All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_HIV_LIFE_CYCLE 12569All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 10461All SZGR genes in this pathway
REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX 6342All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
NOUZOVA_TRETINOIN_AND_H4_ACETYLATION 14385All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
MAHAJAN_RESPONSE_TO_IL1A_UP 8152All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
WHITEFORD_PEDIATRIC_CANCER_MARKERS 11663All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_MIDDLE 9856All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_AND_SATB1_DN 180116All SZGR genes in this pathway
KOHOUTEK_CCNT1_TARGETS 5026All SZGR genes in this pathway
LE_NEURONAL_DIFFERENTIATION_DN 1916All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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