Gene Page: HOMER1

Summary
GeneID  9456
Symbol  HOMER1
Synonyms  HOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1
Description  homer homolog 1 (Drosophila)
See related  HGNC:17512|MIM:604798|Ensembl:ENSG00000152413|HPRD:09211|
Locus tag  -
Gene type  protein-coding
Map location  5q14.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HOMER20.850.73
REEP20.840.88
GALNT140.830.66
ATP13A20.830.88
PPM1J0.820.74
GRIN2D0.820.81
PLA2G150.820.82
CPNE70.810.72
CHAC10.800.87
CHRNA40.800.79
Top 10 negatively co-expressed genes
AF347015.2-0.41-0.45
AF347015.31-0.38-0.44
AF347015.21-0.38-0.44
AF347015.8-0.38-0.44
AF347015.33-0.37-0.43
MT-CO2-0.36-0.44
OAF-0.35-0.41
MT-ATP8-0.35-0.44
AL139819.3-0.35-0.46
AF347015.27-0.35-0.44
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingTAS9808458 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9808458 
GO:0007206metabotropic glutamate receptor, phospholipase C activating pathwayTASglutamate (GO term level: 10)9808459 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9808459 
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI3NESH | SSH3BP3ABI family, member 3Two-hybridBioGRID16189514 
AGAP2CENTG1 | FLJ16430 | GGAP2 | KIAA0167 | PIKEArfGAP with GTPase domain, ankyrin repeat and PH domain 2-HPRD,BioGRID14528310 
C1orf116DKFZp666H2010 | FLJ36507 | MGC2742 | MGC4309 | SARGchromosome 1 open reading frame 116Two-hybridBioGRID16189514 
DNM3KIAA0820 | MGC70433dynamin 3in vitroBioGRID9808459 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1-HPRD,BioGRID9069287 |9808458 
|11418862 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1-HPRD,BioGRID9069287 |9808458 
|11418862 
GRM1GPRC1A | GRM1A | MGLUR1 | MGLUR1A | mGlu1glutamate receptor, metabotropic 1-HPRD9069287 
HOMER1HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1homer homolog 1 (Drosophila)-HPRD9808458 
HOMER3HOMER-3homer homolog 3 (Drosophila)-HPRD9808458 
ITPR1INSP3R1 | IP3R | IP3R1 | SCA15 | SCA16inositol 1,4,5-triphosphate receptor, type 1-HPRD,BioGRID9808459 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkinAffinity Capture-WesternBioGRID11679592 
RYR1CCO | MHS | MHS1 | RYDR | RYR | SKRRryanodine receptor 1 (skeletal)-HPRD,BioGRID12223488 |12810060 
|14660561 
RYR2ARVC2 | ARVD2 | VTSIPryanodine receptor 2 (cardiac)-HPRD,BioGRID12887973 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TRPC1HTRP-1 | MGC133334 | MGC133335 | TRP1transient receptor potential cation channel, subfamily C, member 1Affinity Capture-WesternBioGRID14505576 
TRPC2-transient receptor potential cation channel, subfamily C, member 2 (pseudogene)Affinity Capture-WesternBioGRID14505576 
TRPC5TRP5transient receptor potential cation channel, subfamily C, member 5Affinity Capture-WesternBioGRID14505576 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP 204140All SZGR genes in this pathway
NAGASHIMA_NRG1_SIGNALING_UP 176123All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN 234147All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN 8454All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP 142104All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_ES_1 379235All SZGR genes in this pathway
ONDER_CDH1_TARGETS_2_DN 464276All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_UP 11168All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC 210123All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_DN 409268All SZGR genes in this pathway
HUANG_FOXA2_TARGETS_UP 4528All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_UP 294199All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_DN 170105All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_POLYSOMY7_DN 2417All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_UP 7253All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-369-3p176217681Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37417621768m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-49516291635m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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