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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: MAPK8IP1

Summary

GeneID

9479

Symbol

MAPK8IP1

Synonyms

IB1|JIP-1|JIP1|PRKM8IP

Description

mitogen-activated protein kinase 8 interacting protein 1

Locus tag

Gene type

protein-coding

Map location

11p12-p11.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1391

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005078

MAP-kinase scaffold activity

IPI

11238452

GO:0005515

protein binding

IPI

11726277

GO:0004860

protein kinase inhibitor activity

TAS

9933567

GO:0019894

kinesin binding

IPI

11238452

GO:0016301

kinase activity

IEA

GO:0019901

protein kinase binding

IPI

11238452 |11726277

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016192

vesicle-mediated transport

ISS

GO:0046328

regulation of JNK cascade

ISS

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IEA

GO:0005737

cytoplasm

IDA

10574993

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	12194869
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	JIP1 interacts with APP.	BIND	11724784
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD	11517249 \|11724784
DUSP16	KIAA1700 \| MGC129701 \| MGC129702 \| MKP-7 \| MKP7	dual specificity phosphatase 16	-	HPRD,BioGRID	12524447
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	-	HPRD,BioGRID	10827173
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD,BioGRID	10827173
LRP8	APOER2 \| HSZ75190 \| MCI1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	Two-hybrid	BioGRID	10827173
MAP2K7	Jnkk2 \| MAPKK7 \| MKK7 \| PRKMK7	mitogen-activated protein kinase kinase 7	-	HPRD,BioGRID	10490659
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	Affinity Capture-Western Reconstituted Complex	BioGRID	10490659
MAP3K11	MGC17114 \| MLK-3 \| MLK3 \| PTK1 \| SPRK	mitogen-activated protein kinase kinase kinase 11	Affinity Capture-Western Reconstituted Complex	BioGRID	10490659
MAP3K12	DLK \| MUK \| ZPK \| ZPKP1	mitogen-activated protein kinase kinase kinase 12	Affinity Capture-Western Reconstituted Complex	BioGRID	10490659
MAP3K13	LZK \| MGC133196	mitogen-activated protein kinase kinase kinase 13	-	HPRD,BioGRID	11726277
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	-	HPRD,BioGRID	9733513
MAPK8IP1	IB1 \| JIP-1 \| JIP1 \| PRKM8IP	mitogen-activated protein kinase 8 interacting protein 1	Affinity Capture-Western	BioGRID	10490659
MAPK8IP2	IB2 \| JIP2 \| PRKM8IPL	mitogen-activated protein kinase 8 interacting protein 2	Affinity Capture-Western Reconstituted Complex	BioGRID	10490659
MAPK8IP3	DKFZp762N1113 \| FLJ00027 \| JIP3 \| JSAP1 \| KIAA1066 \| SYD2	mitogen-activated protein kinase 8 interacting protein 3	-	HPRD,BioGRID	10629060
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	Affinity Capture-Western Reconstituted Complex	BioGRID	9733513 \|10490659
PAX2	-	paired box 2	Affinity Capture-Western	BioGRID	11700324
RECQL5	FLJ90603 \| RECQ5	RecQ protein-like 5	Two-hybrid	BioGRID	16169070
RGNEF	DKFZp686P12164 \| FLJ21817 \| KIAA1998	Rho-guanine nucleotide exchange factor	-	HPRD	10574993
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD	11790792
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD,BioGRID	12024021

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
KEGG_MAPK_SIGNALING_PATHWAY	267	205	All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	45	35	All SZGR genes in this pathway
SIG_CD40PATHWAYMAP	34	28	All SZGR genes in this pathway
ST_GRANULE_CELL_SURVIVAL_PATHWAY	27	23	All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY	82	62	All SZGR genes in this pathway
ST_FAS_SIGNALING_PATHWAY	65	54	All SZGR genes in this pathway
PID_REELIN_PATHWAY	29	29	All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP	501	327	All SZGR genes in this pathway
LANDIS_ERBB2_BREAST_TUMORS_324_UP	150	93	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP	214	144	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN	196	131	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_6_7WK_UP	197	135	All SZGR genes in this pathway
RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_DN	8	6	All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_UP	100	75	All SZGR genes in this pathway
SNIJDERS_AMPLIFIED_IN_HEAD_AND_NECK_TUMORS	37	27	All SZGR genes in this pathway
KANG_GIST_WITH_PDGFRA_UP	50	27	All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1	229	137	All SZGR genes in this pathway
GOERING_BLOOD_HDL_CHOLESTEROL_QTL_TRANS	14	7	All SZGR genes in this pathway
LE_EGR2_TARGETS_DN	108	84	All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP	157	105	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2	43	38	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_UP	317	208	All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP	461	298	All SZGR genes in this pathway
MCCABE_BOUND_BY_HOXC6	469	239	All SZGR genes in this pathway
RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_DN	159	105	All SZGR genes in this pathway
ZHANG_TLX_TARGETS_36HR_UP	221	150	All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_DN	181	97	All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2	491	319	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B	549	316	All SZGR genes in this pathway
LIU_IL13_MEMORY_MODEL_UP	17	12	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-183	726	732	m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-214	58	64	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-217	171	177	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-24	460	466	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.