Gene Page: AKAP5

Summary
GeneID  9495
Symbol  AKAP5
Synonyms  AKAP75|AKAP79|H21
Description  A kinase (PRKA) anchor protein 5
See related  HGNC:375|MIM:604688|Ensembl:ENSG00000179841|HPRD:05255|
Locus tag  -
Gene type  protein-coding
Map location  14q21-q24
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1574 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TLN10.860.85
TJP10.850.85
DENND5A0.850.85
PHLPP10.840.85
PLEKHG30.830.84
CLN80.830.83
WNK10.830.84
KIF13A0.820.84
WWC30.810.85
USP540.810.82
Top 10 negatively co-expressed genes
PFDN5-0.51-0.55
ST20-0.49-0.54
RPL31-0.49-0.56
COX16-0.48-0.51
TIMM8B-0.48-0.53
C8orf59-0.48-0.46
RPL35-0.48-0.55
PFDN4-0.47-0.49
PSMA6-0.46-0.49
NDUFAF2-0.45-0.45
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0051018protein kinase A bindingTAS1512224 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)1512224 
GO:0007165signal transductionIEA-
GO:0007165signal transductionNAS1512224 
GO:0006605protein targetingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneNAS1512224 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADRB2ADRB2R | ADRBR | B2AR | BAR | BETA2ARadrenergic, beta-2-, receptor, surface-HPRD10753752 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)-HPRD10939335 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD10939335 
GABRB1-gamma-aminobutyric acid (GABA) A receptor, beta 1-HPRD12595241 
GABRB3ECA5 | MGC9051gamma-aminobutyric acid (GABA) A receptor, beta 3Affinity Capture-Western
Reconstituted Complex		BioGRID12595241 
IQGAP1HUMORFA01 | KIAA0051 | SAR1 | p195IQ motif containing GTPase activating protein 1-HPRD,BioGRID12938160 
KCNJ2HHBIRK1 | HHIRK1 | IRK1 | KIR2.1 | LQT7 | SQT3potassium inwardly-rectifying channel, subfamily J, member 2-HPRD11287423 
PPP3CACALN | CALNA | CALNA1 | CCN1 | CNA1 | PPP2Bprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform-HPRD,BioGRID7528941 |9765270 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alpha-HPRD,BioGRID12672969 
PRKAR2BPRKAR2 | RII-BETAprotein kinase, cAMP-dependent, regulatory, type II, beta-HPRD,BioGRID8509414 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_TCR_CALCIUM_PATHWAY 2923All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 4328All SZGR genes in this pathway
REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 2823All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP 184125All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_UP 16792All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
ZHANG_GATA6_TARGETS_DN 6446All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP 210124All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway


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