Gene Page: BCAR1

Summary
GeneID  9564
Symbol  BCAR1
Synonyms  CAS|CAS1|CASS1|CRKAS|P130Cas
Description  breast cancer anti-estrogen resistance 1
See related  HGNC:971|MIM:602941|Ensembl:ENSG00000050820|HPRD:04248|
Locus tag  -
Gene type  protein-coding
Map location  16q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.094 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS8070403 
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI9748234 |10339567 |10587647 
|11782456 |14688263 
|16105984 
GO:0017124SH3 domain bindingIEA-
GO:0019903protein phosphatase bindingIPI9285683 
GO:0019901protein kinase bindingIPI8070403 |8649368 |9020138 
|9472046 |10026197 
|16245368 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthTAS11607844 
GO:0007186G-protein coupled receptor protein signaling pathwayISS-
GO:0007186G-protein coupled receptor protein signaling pathwayNAS10092204 
GO:0007173epidermal growth factor receptor signaling pathwayISS-
GO:0007155cell adhesionIEA-
GO:0007229integrin-mediated signaling pathwayIDA8649368 
GO:0007229integrin-mediated signaling pathwayISS-
GO:0008283cell proliferationTAS10639512 
GO:0008286insulin receptor signaling pathwayISS-
GO:0048011nerve growth factor receptor signaling pathwayISS-
GO:0048008platelet-derived growth factor receptor signaling pathwayISS-
GO:0007015actin filament organizationIDA16105984 
GO:0007015actin filament organizationISS-
GO:0042981regulation of apoptosisTAS11607844 
GO:0050852T cell receptor signaling pathwayNAS9295052 
GO:0051301cell divisionNAS10675905 
GO:0030335positive regulation of cell migrationIDA9472046 
GO:0030335positive regulation of cell migrationISS-
GO:0050853B cell receptor signaling pathwayIDA9020138 
GO:0050853B cell receptor signaling pathwayISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0001726ruffleIDA9472046 
GO:0001726ruffleISS-
GO:0005624membrane fractionIDA8070403 
GO:0005624membrane fractionISS-
GO:0005737cytoplasmIDA8070403 
GO:0005737cytoplasmISS-
GO:0030027lamellipodiumIEA-
GO:0005925focal adhesionISS-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID7780740 
BCAR3KIAA0554 | NSP2 | SH2D3Bbreast cancer anti-estrogen resistance 3Affinity Capture-WesternBioGRID12517963 
CD2APCMS | DKFZp586H0519CD2-associated protein-HPRD,BioGRID10339567 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Affinity Capture-Western
Reconstituted Complex		BioGRID9581808 |9920935 
|10085298 |10329689 
|11369773 |12615911 
|14657239 |15492270 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID10753828 
CSPG4HMW-MAA | MCSP | MCSPG | MEL-CSPG | MSK16 | NG2chondroitin sulfate proteoglycan 4-HPRD10587647 
DOCK1DOCK180 | ced5dedicator of cytokinesis 1-HPRD,BioGRID12615911 
E2F2E2F-2E2F transcription factor 2Two-hybridBioGRID16169070 
EFSCAS3 | CASS3 | EFS1 | EFS2 | HEFS | SINembryonal Fyn-associated substrateTwo-hybridBioGRID16169070 
FESFPSfeline sarcoma oncogeneAffinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID8999909 
FXYD6-FXYD domain containing ion transport regulator 6Two-hybridBioGRID16169070 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9188452 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD8649368 |8700507 
Affinity Capture-Western
Reconstituted Complex		BioGRID10085298 |10822386 
GSNDKFZp313L0718gelsolin (amyloidosis, Finnish type)-HPRD11577104 
HCKJTK9hemopoietic cell kinase-HPRD,BioGRID9020138 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Two-hybridBioGRID16169070 
ID2GIG8 | ID2A | ID2H | MGC26389 | bHLHb26inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinAffinity Capture-WesternBioGRID10502414 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1-HPRD,BioGRID11158326 
JUBAjuba | MGC15563jub, ajuba homolog (Xenopus laevis)-HPRD15728191 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9020138 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID9581808 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Affinity Capture-WesternBioGRID11432831 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID12135674 
NEDD9CAS-L | CAS2 | CASL | CASS2 | HEF1 | dJ49G10.2 | dJ761I2.1neural precursor cell expressed, developmentally down-regulated 9-HPRD8668148 |9366405 
Affinity Capture-WesternBioGRID10502414 
NPHP1FLJ97602 | JBTS4 | NPH1 | SLSN1nephronophthisis 1 (juvenile)-HPRD,BioGRID10739664 |11493697 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID10799562 
PKD1PBPpolycystic kidney disease 1 (autosomal dominant)-HPRD11113628 
PPP1R15AGADD34protein phosphatase 1, regulatory (inhibitor) subunit 15ATwo-hybridBioGRID16169070 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD11514617 
Affinity Capture-Western
Reconstituted Complex		BioGRID8649427 |8810278 
|11577104 |12135674 
|12615911 
-HPRD7479864 |11514617 
CAS interacts with FAK. This interaction was modeled on a demonstrated interaction between human CAS and mouse FAK.BIND9148935 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID8995252 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID8940134 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-WesternBioGRID9188452 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID8887669 |9285683 
|9748319 |12714323 
-HPRD8887669 |9285683 
|9748319 |9920935 
|12714323 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD10822386 
PTPRHFLJ39938 | MGC133058 | MGC133059 | SAP-1protein tyrosine phosphatase, receptor type, H-HPRD,BioGRID11278335 
PXNFLJ16691paxillinAffinity Capture-WesternBioGRID8810278 |11577104 
RAPGEF1C3G | DKFZp781P1719 | GRF2Rap guanine nucleotide exchange factor (GEF) 1-HPRD,BioGRID9748234 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12446789 |12819203 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SH2D3ANSP1SH2 domain containing 3A-HPRD,BioGRID10187783 
SH2D3CCHAT | FLJ39664 | NSP3 | PRO34088SH2 domain containing 3CAffinity Capture-WesternBioGRID10692442 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1Affinity Capture-WesternBioGRID11071869 
SNIPKIAA1684SNAP25-interacting protein-HPRD,BioGRID14657239 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)c-Src interacts with CAS.BIND9148935 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10085298 |10487518 
|10739664 |11514617 
|12397603 |12615911 
TNS1DKFZp586K0617 | MGC88584 | MST091 | MST122 | MST127 | MSTP122 | MSTP127 | MXRA6 | TNStensin 1Affinity Capture-WesternBioGRID8810278 
TRIP6MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1thyroid hormone receptor interactor 6-HPRD,BioGRID11782456 |14688263 
VCLCMD1W | MVCLvinculinAffinity Capture-WesternBioGRID11577104 
VPS11END1 | PEP5 | RNF108 | hVPS11vacuolar protein sorting 11 homolog (S. cerevisiae)Two-hybridBioGRID16169070 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID10026197 
ZYXESP-2 | HED-2zyxinAffinity Capture-WesternBioGRID11782456 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 11878All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_CELL2CELL_PATHWAY 1411All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_INTEGRIN_PATHWAY 3829All SZGR genes in this pathway
BIOCARTA_PYK2_PATHWAY 3124All SZGR genes in this pathway
BIOCARTA_PTEN_PATHWAY 1814All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_ENDOTHELIN_PATHWAY 6352All SZGR genes in this pathway
PID_PRL_SIGNALING_EVENTS_PATHWAY 2317All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_PTP1B_PATHWAY 5240All SZGR genes in this pathway
PID_AVB3_OPN_PATHWAY 3129All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_NETRIN_PATHWAY 3227All SZGR genes in this pathway
PID_INTEGRIN_A9B1_PATHWAY 2518All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_IGF1_PATHWAY 3023All SZGR genes in this pathway
PID_AVB3_INTEGRIN_PATHWAY 7553All SZGR genes in this pathway
PID_UPA_UPAR_PATHWAY 4230All SZGR genes in this pathway
PID_PDGFRB_PATHWAY 129103All SZGR genes in this pathway
PID_EPHA2_FWD_PATHWAY 1916All SZGR genes in this pathway
PID_INTEGRIN_A4B1_PATHWAY 3324All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 7948All SZGR genes in this pathway
REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS 1511All SZGR genes in this pathway
REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING 2717All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION 3623All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
WINTER_HYPOXIA_UP 9257All SZGR genes in this pathway
CHEMNITZ_RESPONSE_TO_PROSTAGLANDIN_E2_DN 391222All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BURTON_ADIPOGENESIS_9 9259All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_DN 6435All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SUBTIL_PROGESTIN_TARGETS 3625All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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